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Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

A new study discussed the findings of Chai et al., which revealed that triple specificity protein phosphatase (ptpB) secreted by Mycobacterium tuberculosis inhibits pyroptosis and the release of cytokines by macrophages, allowing M. tuberculosis to invade the immune system.

19 Dec 2022

mRNA vaccine methodologies: Production, value and spectrometer use

To be decided by the editor

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 16 Dec 2022

The therapeutic effects and safety of psychedelics

Psychedelics are reported to have rapid-onset and long-lasting therapeutic benefits after a single or few doses.

14 Dec 2022

How vaping impacts alveolar macrophage lipid content

The use of e-cigs increases the risk of acute respiratory syndrome.

11 Dec 2022

An epigenetic modification improves the defense against infections, research shows

During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against the pathogens.

9 Dec 2022

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

A fundamental challenge in drug development is the balance between optimizing a drug's lock-and-key fit with its target and the drug's ability to make its way across the cellular membrane and access that target.

8 Dec 2022

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Researchers investigated the immunological mechanisms behind the decreasing efficacy of COVID-19 vaccines by evaluating the durability and magnitude of neutralizing antibodies and memory B and T cell responses to booster doses of mRNA COVID-19 vaccine.

8 Dec 2022

Understanding why respiratory infections are more common in the winter

Researchers investigate the role of extracellular vesicles in the innate nasal mucosal response to several respiratory viruses.

6 Dec 2022

The critical role of flow cytometry in CAR+ T-Cell trials

In this interview, Ryan Muise talks to AZoNetwork about the added value of using flow cytometry in CAR T-Cell clinical trials.

From Cerba Research 6 Dec 2022

Researchers examine hesitancy to use evidence-based treatment for childhood anxiety disorders

Both medication and a specific form of talk therapy called cognitive behavioral therapy (CBT) are proven evidence-based treatments for children and adolescents with anxiety disorders.

5 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

Study suggests persistent immune activation and long COVID correlate independently with severe COVID-19

Researchers investigated whether severe COVID-19 patients exhibited inflammation and immune activation three months after hospitalization and explored the associations among COVID-19 severity, long COVID, and immune activation.

30 Nov 2022

What genes are associated with asthma exacerbations?

In a new study, researchers reviewed the genomics, transcriptomics, and epigenetics of asthma exacerbations (AEs).

29 Nov 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

In a new study, researchers developed two monkeypox (MPX) virus (MPXV) quadrivalent messenger ribonucleic acid (mRNA) vaccines, mRNA-A-lipid nanoparticle (LNP) and mRNA-B-LNP.

28 Nov 2022

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Researchers used cellular cryo-electron tomography (cryo-ET) to demonstrate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in coronavirus disease 2019 (COVID-19)-triggered severe coagulopathies.

28 Nov 2022

Scientists develop preclinical model of scrub typhus disease

Scientists have developed an animal model of scrub typhus using outbred CD-1 mice. Using the model, they have characterized host susceptibility to the causative pathogen, disease pathogenesis, and immune responses. The study has been published in the journal PLOS Neglected Tropical Diseases.

27 Nov 2022

The potential of Sofosbuvir against COVID-19 neurological symptoms

Researchers discuss how SARS-CoV-2 infects cortical neurons and damages their synapses that form the connection between brain cells.

25 Nov 2022

Fungi detected in 35 cancer types, often intracellular

In a recent article published in the journal Cell, researchers found fungal deoxyribonucleic acid (DNA) and cells at low abundances across many human cancers, with cancer type-dependent variations in fungus community composition and fungal-bacteriome interactions.

22 Nov 2022

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

In a recent study posted to the bioRxiv* preprint server, researchers in China demonstrated the efficacy of three messenger ribonucleic acid (mRNA) technology-based Monkeypox virus (MPXV) vaccines in combating a lethal Vaccinia virus (VACV) challenge in mice models.

22 Nov 2022

Intracellular News and Research

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

mRNA vaccine methodologies: Production, value and spectrometer use

The therapeutic effects and safety of psychedelics

How vaping impacts alveolar macrophage lipid content

An epigenetic modification improves the defense against infections, research shows

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Understanding why respiratory infections are more common in the winter

The critical role of flow cytometry in CAR+ T-Cell trials

Researchers examine hesitancy to use evidence-based treatment for childhood anxiety disorders

Detection of filoviruses by the innate immune system

Study suggests persistent immune activation and long COVID correlate independently with severe COVID-19

What genes are associated with asthma exacerbations?

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Scientists develop preclinical model of scrub typhus disease

The potential of Sofosbuvir against COVID-19 neurological symptoms

Fungi detected in 35 cancer types, often intracellular

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

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