Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Researchers investigated the efficacy of two multi-kinase inhibitors, olverembatinib and ponatinib, in inhibiting SARS-CoV-2 omicron-mediated cytokine release in human peripheral blood mononuclear cells.

10 Feb 2022

Study shows how gut bacteria could undermine immunity in pancreatic cancer

Researchers at the University of Toronto and University Health Network have shown how probiotic bacteria in the gut could undermine immunity in pancreatic cancer, pointing toward more personalized cancer treatments.

8 Feb 2022

Researchers develop influenza virus-like particle-based hybrid vaccine for both influenza and SARS-CoV-2 viruses

In a new study, a team of researchers developed a hybrid vaccine for SARS-CoV-2 and influenza viruses using influenza virus-like particles (VLP).

4 Feb 2022

Study finds limited evidence for IL-1 blockers in treating COVID-19

Researchers assess the effectiveness and safety outcomes of interleukin-1 blocking agents in the treatment of COVID-19.

31 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

This study showed inhalable Covid-19 mimetic particle carriers as potential, versatile, aerosolizable COVID-19 vaccine candidates if worked on with continued optimization and refinement.

28 Jan 2022

Nano-bubbles containing ACE2 protein can block infection from broad strains of SARS-CoV-2

Scientists at Northwestern Medicine and The University of Texas MD Anderson Cancer Center have identified natural nano-bubbles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients and discovered these nano-sized particles can block infection from broad strains of SARS-CoV-2 virus in preclinical studies.

21 Jan 2022

Natural extracellular vesicles containing ACE2 protein could fight new SARS-CoV-2 variants

Scientists at The University of Texas MD Anderson Cancer Center and Northwestern Medicine have identified natural extracellular vesicles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients that can block infection from broad strains of SARS-CoV-2 virus in preclinical studies. The study was published today in Nature Communications.

20 Jan 2022

The latest advancements in polymer-based nanotechnology approaches used to fight against SARS-CoV-2

A recent review discusses the engineering versatility of polymeric nanoparticles - making a good therapeutic alternative against coronavirus diseases.

19 Jan 2022

Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

Researchers determine the driving factors for disease severity and death due to COVID-19.

17 Jan 2022

COPD: Ion channels in immune cells could potentially be targets for new therapies

Chronic obstructive pulmonary disease – COPD for short – is one of the most common diseases of the lung. It affects almost 300 million people worldwide, of which about three million die every year.

17 Jan 2022

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can "sniff" out their surroundings and cause inflammation.

13 Jan 2022

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

A new study reveals the existence of a powerful ally in the fight against cardiovascular disease, a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, a molecule which fosters "good" macrophage behavior within the vessel wall.

11 Jan 2022

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy- also pioneered at Penn- for solid cancer tumors and offers a promising new strategy in the fight against cancer.

11 Jan 2022

SARS-CoV-2 activates microglia in the brain

Researchers demonstrate that SARS-CoV-2 can infect the human microglia.

10 Jan 2022

Researchers study immune cell invasion process in living fruit fly embryos

To fight infections and heal injuries, immune cells need to enter tissue. They also need to invade tumors to fight them from within.

6 Jan 2022

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

The LIVE-AIR phase 3 clinical trial is associated with early treatment of hyperinflammatory response with the humanized monoclonal antibody lenzilumab in COVID-19 patients with decreased oxygen saturation. The study results are posted to the medRxiv* preprint server.

6 Jan 2022

Scientists unravel how LPS prevents or promotes development of allergic disease

Immunologists have long been baffled by LPS, the bacterial lipopolysaccharide that helps form the cell walls of Gram-negative bacteria.

5 Jan 2022

Inhaled CBD shrinks glioblastoma’s size in an animal model

Inhaled CBD shrinks the size of the highly aggressive, lethal brain tumor glioblastoma in an animal model by reducing the essential support of its microenvironment, researchers report.

24 Dec 2021

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of "intruding" viruses like human immunodeficiency virus (HIV).

9 Dec 2021

Macrophage News and Research

Further Reading

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Study shows how gut bacteria could undermine immunity in pancreatic cancer

Researchers develop influenza virus-like particle-based hybrid vaccine for both influenza and SARS-CoV-2 viruses

Study finds limited evidence for IL-1 blockers in treating COVID-19

Study reveals link between muscular dystrophy and sphingolipids

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

Nano-bubbles containing ACE2 protein can block infection from broad strains of SARS-CoV-2

Natural extracellular vesicles containing ACE2 protein could fight new SARS-CoV-2 variants

The latest advancements in polymer-based nanotechnology approaches used to fight against SARS-CoV-2

Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

COPD: Ion channels in immune cells could potentially be targets for new therapies

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

SARS-CoV-2 activates microglia in the brain

Researchers study immune cell invasion process in living fruit fly embryos

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

Scientists unravel how LPS prevents or promotes development of allergic disease

Inhaled CBD shrinks glioblastoma’s size in an animal model

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

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