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New rapid CRISPR-based test for sensitive SARS-CoV-2 detection

A new study reports the approval of a new CRISPR-based coronavirus test that is both sensitive and rapid and intended to help reduce the time required to test symptomatic or potentially contagious cases.

13 May 2020

Researchers use “gene drive” technology to eliminate malaria mosquitoes in lab experiments

A modification that creates more male offspring was able to eliminate populations of malaria mosquitoes in lab experiments.

13 May 2020

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

Aiming to identify new therapeutic strategies for the aggressive hematological disease T-cell acute lymphoblastic leukemia (T-ALL), Rutgers Cancer Institute of New Jersey resident researcher Daniel Herranz Benito, PhD, along with collaborators from Princeton University, found a new drug that has therapeutic effect against T-ALL by inhibiting SHMT and is complementary to standard-of-care treatment.

12 May 2020

Could JAK blockers help treat COVID-19?

A new study published in the journal Science Immunology in May 2020 reports that compounds that safely inhibit the JAK protein could be useful in treating COVID-19.

12 May 2020

SARS-CoV-2 cell entry affinity varies across different host species

A new study from India, currently available on the preprint server bioRxiv*, estimated the probability and readiness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect cells of different animal species – and revealed many of them that could act as disease carriers.

12 May 2020

Potential for COVID-19 transmission from human eye

A new study published on the preprint server bioRxiv* in May 2020 reports the presence of ACE2 receptors in the eye at high concentrations. These molecules are the entry points for the SARS-CoV-2 virus that is causing the ongoing COVID-19 pandemic.

12 May 2020

Symptomatic COVID-19 patients less likely to be smokers

As the COVID-19 pandemic rages in many parts of the world, a new study shows that smoking may not play a significant role in increasing the severity of illness in these patients. The study is published on the preprint server medRxiv* in May 2020.

12 May 2020

SARS-CoV-2 binds heparan sulfate, preventing host cell infection

A new study published in May 2020 on the preprint server bioRxiv shows that the SARS-CoV-2 virus can bind to a sugar molecule called heparan sulfate (HS), thereby hindering its entry into the host cell.

12 May 2020

Study reveals molecular mechanism of boswellic acid that plays key role in frankincense effect

Once upon a time, the Three Kings brought precious gifts to the new-born baby Jesus: as well as gold and myrrh, they also had frankincense in their bags.

12 May 2020

SARS-CoV-2 could spread through surface of the eyes

Researchers from Johns Hopkins University School of Medicine have found that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus could spread via ocular or eye surfaces. This is because the receptor where the virus binds – the ACE2, is also expressed on human eyes, they note.

11 May 2020

Varied performance of SARS-CoV-2 antibody tests in detecting protective immunity

The performance of commercially available serological tests in real patient samples and the correlates of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provided by IgG antibodies are still a matter of debate. A new bioRxiv preprint paper cross-examines the performance of several assays and proclaims the plaque reduction neutralization test (PRNT) as a method of choice.

11 May 2020

New biosensor system may hold the key to personal management of gout

In a recent article published in the February issue of the journal Sensors, researchers at Texas A&M University have reported a technology that might help people with gout disease monitor their symptoms better.

11 May 2020

Therapeutic peptides that can be taken orally

Peptides are short chains of amino acids that occur in our body, in plants or bacteria to control diverse functions.

11 May 2020

No evidence COVID-19 is spread by fecal-oral transmission

A new study published on the preprint server medRxiv* in May 2020 shows that in patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pharyngeal and fecal samples, the virus persists longer in the fecal samples than in the pharyngeal samples. However, fecal-oral transmission does not appear to occur.

10 May 2020

Low-molecular-weight drugs could help against COVID-19 says study

Chinese researchers have worked on using existing low molecular weight drugs to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease.

10 May 2020

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

A new case report released on the preprint server medRxiv* provides a detailed longitudinal analysis of the immune response associated with a fatal case of coronavirus disease (COVID-19). It highlights the need for addressing the source of hyper inflammation in the treatment approach.

10 May 2020

Study shows COVID-19 vulnerability is highly dependent on host genetic architecture

A new US study available on the preprint server medRxiv reveals certain genetic variations that are associated with infection susceptibility and diverse clinical presentation of coronavirus disease (COVID-19) – including asymptomatic cases and severe forms of the disease in younger patients.

10 May 2020

ACE inhibitors should not be discontinued over fears about COVID-19, say researchers

Researchers in Europe have found no evidence to support previous reports that the use of drugs that target the renin-angiotensin-aldosterone system (RAAS) increases susceptibility to coronavirus disease 2019 (COVID-19). The research is published in the European Heart Journal.

10 May 2020

Texas A&M study offers hope for young children diagnosed with Menkes disease

A Texas A&M AgriLife Research team has good news for patients with copper-deficiency disorders, especially young children diagnosed with Menkes disease.

9 May 2020

Study shows how long-term use of acid suppressants could increase risk of dementia

Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia.

8 May 2020

Enzyme News and Research

New rapid CRISPR-based test for sensitive SARS-CoV-2 detection

Researchers use “gene drive” technology to eliminate malaria mosquitoes in lab experiments

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

Could JAK blockers help treat COVID-19?

SARS-CoV-2 cell entry affinity varies across different host species

Potential for COVID-19 transmission from human eye

Symptomatic COVID-19 patients less likely to be smokers

SARS-CoV-2 binds heparan sulfate, preventing host cell infection

Study reveals molecular mechanism of boswellic acid that plays key role in frankincense effect

SARS-CoV-2 could spread through surface of the eyes

Varied performance of SARS-CoV-2 antibody tests in detecting protective immunity

New biosensor system may hold the key to personal management of gout

Therapeutic peptides that can be taken orally

No evidence COVID-19 is spread by fecal-oral transmission

Low-molecular-weight drugs could help against COVID-19 says study

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

Study shows COVID-19 vulnerability is highly dependent on host genetic architecture

ACE inhibitors should not be discontinued over fears about COVID-19, say researchers

Texas A&M study offers hope for young children diagnosed with Menkes disease

Study shows how long-term use of acid suppressants could increase risk of dementia

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