Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Transition announces positive results from ELND005 AME and renal clearance studies

Transition Therapeutics Inc. today announced results from two phase 1 clinical studies of neuropsychiatric drug candidate ELND005. These studies, an absorption-metabolism-excretion ("AME") study and a renal clearance study, are specialized clinical pharmacology trials that are required by the United States Food and Drug Administration for the approval of most drugs in development.

26 Mar 2015

Immunotherapy reverses memory problems in animal model of Alzheimer's disease

A new study from the University of Texas Medical Branch at Galveston has revealed that a single dose of an immunotherapy reverses memory problems in an animal model of Alzheimer's disease. The article appears in the March 25 issue of the Journal of Neuroscience.

26 Mar 2015

UCLA-led team validates first standardized protocol for tracking early signs of Alzheimer's disease

After six years of painstaking research, a UCLA-led team has validated the first standardized protocol for measuring one of the earliest signs of Alzheimer's disease -- the atrophy of the part of the brain known as the hippocampus.

26 Mar 2015

Having strong purpose in life may give you better brain health

Having a strong sense that your life has meaning and direction may make you less likely to develop areas of brain damage caused by blockages in blood flow as you age. This research is reported in the American Heart Association's journal Stroke.

25 Mar 2015

New research finds link between milk consumption and high levels of glutathione in the brain

New research conducted at the University of Kansas Medical Center has found a correlation between milk consumption and the levels of a naturally-occurring antioxidant called glutathione in the brain in older, healthy adults.

25 Mar 2015

Study: Progression of dysfunctional tau protein drives cognitive decline in Alzheimer's disease

By examining more than 3,600 postmortem brains, researchers at Mayo Clinic's campuses in Jacksonville, Florida, and Rochester, Minnesota, have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer's disease.

24 Mar 2015

New report highlights the need for disclosing Alzheimer's diagnosis to patients

The Alzheimer's Association's 2015 Alzheimer's Disease Facts and Figures report, released today, found that only 45 percent of people with Alzheimer's disease or their caregivers say they were told the diagnosis by their doctor.

24 Mar 2015

Keystone meeting focuses on neuroinflammation, Alzheimer's and other neurodegenerative diseases

As Alzheimer's disease sweeps through the brain, do the brain's immune cells sit idly by and let it happen? Or could they overreact and make the disease worse?

23 Mar 2015

Olive ingredients may prevent Alzheimer's disease

It has long been proven that people who follow a Mediterranean diet and keep physically and mentally active are less likely to suffer from dementia. Olives in particular appear to play a key role in this regard. But just what are the substances contained in these small, oval fruit that are so valuable? This is what a Hessen-based group of researchers from the Goethe University Frankfurt, the Technical University of Darmstadt and Darmstadt company N-Zyme BioTec GmbH intends to find out. The three-year project "NeurOliv" has a project volume of 1.3 million Euros and is funded by the Federal Ministry of Education and Research as part of the high-tech initiative "KMU-innovativ Biochance".

20 Mar 2015

Cambridge scientists successfully create 'mini-lungs' to study cystic fibrosis

Scientists at the University of Cambridge have successfully created 'mini-lungs' using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be used to test potential new drugs for this debilitating lung disease.

20 Mar 2015

New diet may significantly lower risk of Alzheimer's disease

A new diet, appropriately known by the acronym MIND, could significantly lower a person's risk of developing Alzheimer's disease, even if the diet is not meticulously followed, according to a paper published online for subscribers in March in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

20 Mar 2015

RNA molecule can be manipulated to generate more neurons from neural stem cells

A research team at UC San Francisco has discovered an RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells.

20 Mar 2015

BAI researchers develop new brain image analysis method to better track amyloid changes

Researchers from Banner Alzheimer's Institute have developed a new brain image analysis method to better track the progression of beta-amyloid plaque deposition, a characteristic brain abnormality in Alzheimer's disease, according to a study published in the March issue of the Journal of Nuclear Medicine.

20 Mar 2015

β-amyloid cleared of blame for early memory decline

A “seminal” imaging study suggests that worsening memory in adults is not necessarily an indicator of β-amyloid deposition.

19 Mar 2015

AbbVie signs exclusive worldwide license agreement with C2N for Alzheimer's disease therapies

AbbVie today announced that it has entered into an exclusive worldwide license agreement with C2N Diagnostics, a privately held protein diagnostic and therapeutic discovery company, to develop and commercialize a portfolio of anti-tau antibodies for the treatment of Alzheimer's Disease and other neurological disorders.

19 Mar 2015

Death risk is higher for dementia patients who take antipsychotic drugs, new study shows

Drugs aimed at quelling the behavior problems of dementia patients may also hasten their deaths more than previously realized, a new study finds.

19 Mar 2015

Scientists identify mystery behind cell-signaling breakdown that causes heart failure

Working with lab animals and human heart cells, scientists from Johns Hopkins and other institutions have identified what they describe as "the long-sought culprit" in the mystery behind a cell-signaling breakdown that triggers heart failure. The condition, which affects nearly 6 million Americans and 23 million people worldwide, is marked by progressive weakening and stiffening of the heart muscle and the organ's gradual loss of blood-pumping ability.

19 Mar 2015

New scoring system may help predict memory and thinking problems in elderly people

Researchers have developed a new scoring system to help determine which elderly people may be at a higher risk of developing the memory and thinking problems that can lead to dementia, according to a new study published in the March 18, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

19 Mar 2015

Researchers working to develop non-invasive diagnostic technique for detecting Alzheimer's early

The ELEKIN research group of the UPV/EHU-University of the Basque Country is working to develop various non-invasive methodologies for the early detection of Alzheimer's disease.

18 Mar 2015

UT Southwestern neuroscientists identify key brain cells that control circadian rhythms

UT Southwestern Medical Center neuroscientists have identified key cells within the brain that are critical for determining circadian rhythms, the 24-hour processes that control sleep and wake cycles, as well as other important body functions such as hormone production, metabolism, and blood pressure.

18 Mar 2015

Alzheimer's Disease News and Research

Further Reading

Transition announces positive results from ELND005 AME and renal clearance studies

Immunotherapy reverses memory problems in animal model of Alzheimer's disease

UCLA-led team validates first standardized protocol for tracking early signs of Alzheimer's disease

Having strong purpose in life may give you better brain health

New research finds link between milk consumption and high levels of glutathione in the brain

Study: Progression of dysfunctional tau protein drives cognitive decline in Alzheimer's disease

New report highlights the need for disclosing Alzheimer's diagnosis to patients

Keystone meeting focuses on neuroinflammation, Alzheimer's and other neurodegenerative diseases

Olive ingredients may prevent Alzheimer's disease

Cambridge scientists successfully create 'mini-lungs' to study cystic fibrosis

New diet may significantly lower risk of Alzheimer's disease

RNA molecule can be manipulated to generate more neurons from neural stem cells

BAI researchers develop new brain image analysis method to better track amyloid changes

β-amyloid cleared of blame for early memory decline

AbbVie signs exclusive worldwide license agreement with C2N for Alzheimer's disease therapies

Death risk is higher for dementia patients who take antipsychotic drugs, new study shows

Scientists identify mystery behind cell-signaling breakdown that causes heart failure

New scoring system may help predict memory and thinking problems in elderly people

Researchers working to develop non-invasive diagnostic technique for detecting Alzheimer's early

UT Southwestern neuroscientists identify key brain cells that control circadian rhythms

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