Genome News and Research

RSS

D614G mutation enhances stability of SARS-CoV-2 spike protein

A new study, published on the preprint server bioRxiv in November 2020 by researchers at the Indian Institute of Science, has explored this issue further. The researchers have found that this mutation is associated with structural and energetic changes that cause this spike variant to become more available during infection, thus rendering the associated strain more infective.

4 Nov 2020

RNA-binding proteins may suppress antiviral defenses against SARS-CoV-2

Conducted by researchers in South Korea at the Institute for Basic Science and the International Vaccine Institute, a new study published on the preprint server bioRxiv in November 2020 describes the many host proteins that bind with the ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and regulate the replication of the virus.

4 Nov 2020

Chikungunya can infect central nervous system and impair cognitive, motor functions

A study conducted by an international team of researchers with FAPESP's support shows that infection by chikungunya virus can produce even more severe manifestations than the typical symptoms of the disease, such as acute fever, headache, rash, and intense joint and muscle pain.

4 Nov 2020

Genetic mutation may accelerate heart function decline in DMD patients

A mutation in the gene that causes cystic fibrosis may accelerate heart function decline in those with Duchenne muscular dystrophy (DMD), a new study by UT Southwestern researchers suggests.

4 Nov 2020

Europe is the main source of COVID-19 spread, shows study

The University of Huddersfield's Archaeogenetics Research Group has mapped out the dispersal of the SARS-CoV-2 coronavirus, responsible for the current worldwide COVID-19 pandemic, putting Europe centre-stage as the main source of the spread.

4 Nov 2020

Study sheds light on possible lung damage caused by COVID-19 virus

The study, published today in The Lancet's eBioMedicine, by King's College London in collaboration with University of Trieste and the International Centre for Genetic Engineering and Biology in Italy, shows the unique characteristics to the SARS-CoV-2 virus and may explain why patients suffer from 'long COVID'.

4 Nov 2020

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

A team of scientists from the United States has recently revealed that small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease exhibit potent antiviral activity. These inhibitors show better efficacy when used in combination with antiviral medicine Remdesivir. The study is currently available on the bioRxiv* preprint server.

3 Nov 2020

SARS-CoV-2 mutations becoming more contagious

A team of researchers working with Scott Wesley Long from Houston Methodist Hospital and colleagues from Texas, New York, and Illinois studied the patterns of genetic mutations of SARS CoV-2 and its impact on the second wave of infections worldwide.

3 Nov 2020

UConn researcher identifies genes and regulatory elements critical to heart development

The advent of genome science has given researchers an unprecedented ability to understand the root causes of a host of conditions.

3 Nov 2020

SARS-CoV-2 spike D614G variant exhibits enhanced replication and transmissibility

A team of scientists from Switzerland, Germany, and the USA has demonstrated that the S-614G variant can easily bind to the human angiotensin-converting enzyme 2 (ACE2), the cellular gateway of SARS-CoV-2. The variant also showed enhanced replication and transmissibility in animal models.

2 Nov 2020

Two studies find age as a primary factor in melanoma treatment resistance

Age may cause identical cancer cells with the same mutations to behave differently. In animal and laboratory models of melanoma cells, age was a primary factor in treatment response.

2 Nov 2020

Genomic sequence of the White House "superspreader" event

Now, a new study revealed the genetic signature of the SARS-CoV-2 that spread in the White House and most likely infected President Trump. The team applied genomic epidemiology to shed light on the origins of the outbreak

2 Nov 2020

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is safe and ubiquitous in plants and animals, it could be a potential drug against SARS-CoV-2.

1 Nov 2020

Study identifies new cause of inflammation in people living with HIV

While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans - by up to five to 10 years - compared to people without HIV.

30 Oct 2020

Study reveals molecular mechanism that increases the invasiveness of radioresistant cancer cells

Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.

30 Oct 2020

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

Like a key, SARS-CoV-2 - the virus that causes coronavirus disease 2019 (COVID-19) - attaches to specific molecules on the host cell surface, opening gateways into the cell interior.

30 Oct 2020

Study: Toxins produced by tube-dwelling anemones have pharmacological potential

Researchers based in Brazil and the United States have completed the first-ever mapping exercise to profile the toxins produced by tube-dwelling anemones, or cerianthids, a family of marine animals belonging to the same phylum (Cnidaria) as sea anemones, jellyfish and corals.

30 Oct 2020

A2B-COVID: Rapid identification of SARS-CoV-2 transmission

A new study published on the preprint server medRxiv in October 2020 reports a method to assess transmission potential for any event in the current pandemic, using what is known about the virus's spread, data on the mobility of individuals, and new ways of processing genomic sequencing data. The outcome is to determine whether cases are linked or not so as to take action to prevent further spread.

29 Oct 2020

Researchers identify a novel SARS-CoV-2 variant that spread widely across Europe in summer 2020

Researchers from Basel and Spain have identified a novel SARS-CoV-2 variant that has spread widely across Europe in recent months, according to an un-peer-reviewed preprint released this week.

29 Oct 2020

Toxin-carrying virus implicated in the emergence of new Salmonella strain in pigs

Researchers at the Quadram Institute have implicated a toxin-carrying virus in the emergence of a new strain of Salmonella in pigs.

29 Oct 2020

Genome News and Research

D614G mutation enhances stability of SARS-CoV-2 spike protein

RNA-binding proteins may suppress antiviral defenses against SARS-CoV-2

Chikungunya can infect central nervous system and impair cognitive, motor functions

Genetic mutation may accelerate heart function decline in DMD patients

Europe is the main source of COVID-19 spread, shows study

Study sheds light on possible lung damage caused by COVID-19 virus

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

SARS-CoV-2 mutations becoming more contagious

UConn researcher identifies genes and regulatory elements critical to heart development

SARS-CoV-2 spike D614G variant exhibits enhanced replication and transmissibility

Two studies find age as a primary factor in melanoma treatment resistance

Genomic sequence of the White House "superspreader" event

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Study identifies new cause of inflammation in people living with HIV

Study reveals molecular mechanism that increases the invasiveness of radioresistant cancer cells

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

Study: Toxins produced by tube-dwelling anemones have pharmacological potential

A2B-COVID: Rapid identification of SARS-CoV-2 transmission

Researchers identify a novel SARS-CoV-2 variant that spread widely across Europe in summer 2020

Toxin-carrying virus implicated in the emergence of new Salmonella strain in pigs

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

Latest News