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Novel study on molecular interactions could make it easier to develop new medicines

A first-of-its-kind study on molecular interactions by biomedical engineers in the University of Minnesota's College of Science and Engineering will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV, and autoimmune diseases.

3 Jan 2020

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

One in every 15,000 children is affected by Prader-Willi syndrome (PWS), a complex, genetic endocrine condition caused by a disorder of chromosome 15. It's non-inheritable, meaning the condition isn't passed down from a family member.

3 Jan 2020

Structure of most lethal toxin produced by C. difficile bacteria identified

Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The

2 Jan 2020

A reality check on artificial intelligence: Are health care claims overblown?

Health products powered by artificial intelligence, or AI, are streaming into our lives, from virtual doctor apps to wearable sensors and drugstore chatbots.

30 Dec 2019

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

In preclinical experiments, investigators restored p53 using synthetic mRNA nanoparticles, making lung and liver cancer cells susceptible to available cancer drugs.

23 Dec 2019

Exposure to ozone pollution or wood smoke exacerbates lung disease in former and current smokers

Over many years, exposure to the levels of ozone and other forms of pollution found in most U.S. cities and some rural communities can take a toll on a person's health.

23 Dec 2019

Inhibition of a single enzyme may reduce heparin-induced thrombocytopenia

Heparin is widely used as an anticoagulant, but evokes in some patients a potentially life-threatening condition called HIT. Clinical scientists at Ludwig-Maximilians-Universitaet in Munich have now shown that inhibition of a single enzyme may markedly reduce this risk.

21 Dec 2019

p53 may play a more important role in kidney cancer than previously thought

The p53 gene, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could lead to new treatments.

20 Dec 2019

Combined datasets can expedite the discovery and development of new cancer drugs

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types.

20 Dec 2019

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene -- when the gene becomes mutated -- it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth.

20 Dec 2019

NIAID to fund VTEU program and its companion leadership group

The National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, today announced the establishment of the Infectious Diseases Clinical Research Consortium, a clinical trials network that will encompass the Institute's long-standing Vaccine and Treatment Evaluation Units (VTEUs) and create a new consortium leadership group

20 Dec 2019

UVA, Novo Nordisk partner to develop virtual patient modeling for type 2 diabetes

University of Virginia Center for Diabetes Technology and Novo Nordisk today announced that they have entered into a five-year research collaboration where UVA and Novo Nordisk will work together on the development of virtual environments focused on modelling of patients with type 2 diabetes.

19 Dec 2019

Worse long-term control of blood sugar increases risks in diabetic trauma patients

In trauma patients with diabetes, poorer long-term control of blood glucose levels is linked to a higher risk of death and trauma-related complications, reports a study in SHOCK: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society.

18 Dec 2019

Clinical study demonstrates effective alternative to mastectomy for recurrent breast cancer

Mastectomy has historically been the standard treatment for breast cancer patients experiencing recurrence after an initial lumpectomy and whole-breast radiation. Now, a phase 2 clinical trial led by Douglas W. Arthur, M.D., chair and professor in the Department of Radiation Oncology at VCU Massey Cancer Center and VCU School of Medicine, has demonstrated an effective alternative.

18 Dec 2019

Study finds new drivers of destructive inflammation

Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases.

17 Dec 2019

Researchers identify molecular machinery that drives rapid polymerization of actin filaments

Many cells in our body constantly change their shape and move within our tissues. For example, wound healing and the immune system depend on migrating cells.

17 Dec 2019

A promising cellular target for migraine attacks

A recent study published in the journal Cephalalgia, the official journal of the International Headache Society, reported an intriguing discovery.

17 Dec 2019

Study shows nilotinib drug is safe and well tolerated in patients with Parkinson's disease

A clinical trial investigating the repurposed cancer drug nilotinib in people with Parkinson's disease finds that it is reasonably safe and well tolerated.

17 Dec 2019

Penn researchers track defective sperm epigenome linked to male infertility

One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm that fail to "evict" proteins called histones from DNA during development.

16 Dec 2019

Important discovery about male infertility could lead to new treatments

Using a new mouse model, Penn Medicine researchers have identified defects in the sperm epigenome that cause male infertility.

16 Dec 2019

Therapeutics News and Research

Novel study on molecular interactions could make it easier to develop new medicines

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

Structure of most lethal toxin produced by C. difficile bacteria identified

A reality check on artificial intelligence: Are health care claims overblown?

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

Exposure to ozone pollution or wood smoke exacerbates lung disease in former and current smokers

Inhibition of a single enzyme may reduce heparin-induced thrombocytopenia

p53 may play a more important role in kidney cancer than previously thought

Combined datasets can expedite the discovery and development of new cancer drugs

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

NIAID to fund VTEU program and its companion leadership group

UVA, Novo Nordisk partner to develop virtual patient modeling for type 2 diabetes

Worse long-term control of blood sugar increases risks in diabetic trauma patients

Clinical study demonstrates effective alternative to mastectomy for recurrent breast cancer

Study finds new drivers of destructive inflammation

Researchers identify molecular machinery that drives rapid polymerization of actin filaments

A promising cellular target for migraine attacks

Study shows nilotinib drug is safe and well tolerated in patients with Parkinson's disease

Penn researchers track defective sperm epigenome linked to male infertility

Important discovery about male infertility could lead to new treatments

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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