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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Innovative strategy for early diagnosis of schizophrenia

An innovative strategy that analyzes a region of the genome offers the possibility of early diagnosis of schizophrenia, reports a team led by researchers at Baylor College of Medicine.

3 Aug 2021

Novel type of cellular therapy safe for knee pain caused by osteoarthritis, study confirms

A study released in STEM CELLS Translational Medicine has confirmed the safety of a novel type of cellular therapy for knee pain caused by osteoarthritis.

3 Aug 2021

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

The Republic of Belarus Ministry of Health has approved expanding the ongoing clinical trial of CureLab Oncology's Elenagen, an experimental DNA therapy, to include two new arms: 1) hormone-resistant breast cancer; and 2) hormone-resistant metastatic prostate cancer.

3 Aug 2021

Researchers solve century old mystery by identifying how sex cells get the right genetic mix

A new discovery explains what determines the number and position of genetic exchanges that occur in sex cells, such as pollen and eggs in plants, or sperm and eggs in humans.

3 Aug 2021

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

A new strategy for developing vaccines against cancer showed promise in a proof-of-concept study led by scientists at Weill Cornell Medicine, NewYork-Presbyterian and Heidelberg University Hospital.

2 Aug 2021

Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1

A pioneering study reports on the interaction of a tailored titanium oxide nanoparticle (NP) with the full-length SARS-CoV-2 non-structural protein 1 (nsp1). This should be of value in developing new therapeutic tools against coronaviruses that act by targeting their proteins. It could also help map the structure of activated proteins.

2 Aug 2021

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

A new study reports the use of a modified deoxyribonucleic acid (DNA) oligonucleotide that has a 3’ polyadenine (polyA) tail to bind to the 5’-polyU tract in the mouse coronavirus (MHV-A59). Treatment of mouse cells infected with MHV-A59 with this molecule led to a marked reduction in cell deaths.

2 Aug 2021

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

An intriguing new study presents a novel approach to biosensor-based evaluation of promising drugs that could inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via its 3C-like protease (3CLpro), a viral protease.

2 Aug 2021

HPV16 ctDNA assay predicts treatment response in metastatic head and neck cancer

Oncotarget published "Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma" which reported that despite the rising incidence of human papillomavirus related oropharyngeal squamous cell carcinoma, treatment of metastatic disease remains palliative.

2 Aug 2021

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Researchers at the University of Virginia School of Medicine have overturned conventional wisdom on the workings of vital hormone receptors within cells, a finding that could boost drug development for diabetes and related metabolic disorders, cancer and other diseases.

31 Jul 2021

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight - not just a DNA copying error as previously believed, reports a study by Van Andel Institute scientists published today in Science Advances.

30 Jul 2021

Researchers test a library of lipid-based compounds to enable safe delivery of RNA drugs to the lungs

Hokkaido University researchers in Japan created and tested a library of lipid-based compounds to find a way to safely and effectively deliver RNA drugs to the lungs.

30 Jul 2021

Large nanodiscs simulate viral entry into host cells

In a paper recently uploaded to the journal Frontiers in Biotechnology by Padmanabha Das et al. (June 12th, 2020), a method of producing significantly larger homogenous nanodiscs up to 90 nm in diameter is described, and the advantages and applications of such nanodiscs are explored: better replicating the actual curvature and membrane symmetry of a real cell membrane, and allowing much larger or multiple membrane proteins to be loaded simultaneously.

30 Jul 2021

New integrative NGS panel for analysis of standard and novel biomarkers in lymphoid neoplasms

Increasing knowledge about genomic biomarkers has facilitated better monitoring and personalized management of patients with B-cell malignant tumors.

29 Jul 2021

Cats could be a valuable model organism for geneticists, expert says

Although cats have lived alongside humans for millennia, it remains a dogs' world. This bias has historically bled into science as well.

28 Jul 2021

New insights on replication-stress sensitivity in breast cancer cells

Oncotarget published "Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity" which reported that these authors recently documented that gain-of-function mutant p53 R273H in triple negative breast cancer cells interacts with replicating DNA and PARP1.

28 Jul 2021

Analysis of DNA tags could advance the understanding and treatment of many cancers

Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s but with rapid advances in genomics and computational analytics in just the past few years, researchers at Georgetown Lombardi Comprehensive Cancer Center now believe that studying tags, or modifications to this type of DNA, may lead to a better understanding of how to assess, and possibly modulate, treatment approaches for cancer and other diseases.

27 Jul 2021

SARS-CoV-2 interacts with unusual RNA structures in human cells

The study, published in the journal Nucleic Acids Research, demonstrated that G4 ligands, the chemical that binds with G4s, prevent this interaction. The results could pave the way for developing inhibitors of these interactions as potential antiviral compounds.

26 Jul 2021

Comprehensive genomic sequencing essential to capitalize precision medicine for pediatric cancer care

St. Jude Children's Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision medicine.

26 Jul 2021

MUSC Hollings Cancer Center part of promising phase 2 lymphoma clinical trial

MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma.

23 Jul 2021

DNA News and Research

Further Reading

Innovative strategy for early diagnosis of schizophrenia

Novel type of cellular therapy safe for knee pain caused by osteoarthritis, study confirms

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

Researchers solve century old mystery by identifying how sex cells get the right genetic mix

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

HPV16 ctDNA assay predicts treatment response in metastatic head and neck cancer

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

Researchers test a library of lipid-based compounds to enable safe delivery of RNA drugs to the lungs

Large nanodiscs simulate viral entry into host cells

New integrative NGS panel for analysis of standard and novel biomarkers in lymphoid neoplasms

Cats could be a valuable model organism for geneticists, expert says

New insights on replication-stress sensitivity in breast cancer cells

Analysis of DNA tags could advance the understanding and treatment of many cancers

SARS-CoV-2 interacts with unusual RNA structures in human cells

Comprehensive genomic sequencing essential to capitalize precision medicine for pediatric cancer care

MUSC Hollings Cancer Center part of promising phase 2 lymphoma clinical trial

Understanding the DNA Damage Response in Innate Immunity eBook

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