Cell Line News and Research

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SARS-CoV-2 RNA can be reverse-transcribed to be part of chimeric viral-human genome

A new study reveals that the genome of SARS-CoV-2 is inserted into the human genome, accounting for the detection of viral RNAs.

16 Dec 2020

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

In the current COVID-19 pandemic, SARS-CoV-2 has led to millions of infections worldwide, with over 1.5 million deaths.

14 Dec 2020

UCLA researchers identify gene that could help predict cervical cancer treatment response

UCLA researchers have identified a potential diagnostic marker that could help predict how likely someone with cervical cancer is to respond to the standard treatment of chemotherapy and radiation.

11 Dec 2020

Microplastic particles find their way into living cells if exposed to natural aquatic environments

The environment is polluted by microplastics worldwide. The tiny particles enter food chains, and thereby the digestive systems of animals and humans; moreover, they can be inhaled. Instead of being excreted, small microplastics can be incorporated into the body tissue.

10 Dec 2020

MEDS433 hinders SARS-CoV-2 replication

A paper that recently appeared in the preprint server bioRxiv* reports the powerful activity of a compound named MEDS433 against this virus.

10 Dec 2020

ATCC introduces new product segment with launch of SARS-CoV-2 external control kit

ATCC today announced the introduction of its new SARS-CoV-2 External Control Kit for clinical laboratories and test manufacturers.

From American Type Culture Collection (ATCC) 4 Dec 2020

Horizon Discovery licenses CHOSOURCE to Sanyou Biopharmaceuticals Co.

Horizon Discovery today announced that it has granted commercial licenses for its cGMP-compliant CHOSOURCE™ platform to Sanyou Biopharmaceuticals.

From Revvity 2 Dec 2020

Previously uncharacterized protein regulates mitochondrial NAD transporter

For their growth, cells need various nutrients and vitamins. So-called solute carriers (SLC), proteins that can transport such substances across the boundaries of cellular membranes, play a central role in metabolism.

1 Dec 2020

Are SARS-CoV-2 protease inhibitors effective antivirals in treating COVID-19?

Many antiviral development studies have focused on the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), given their central role in viral replication. A new study draws attention to the high odds that these may not have anti-infective activity because of the redundant pathways present in human host cells.

30 Nov 2020

Monoclonal antibody HB27 shows potent neutralizing activity against SARS-CoV-2

A new study reports a very promising anti-SARS-CoV-2 monoclonal antibody, HB27, that appears to have two distinct mechanisms of action inhibiting the virus-host cell interaction and subsequent infection.

27 Nov 2020

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

A team of researchers based in Iran have explored the role of micro-RNA in COVID-19. Their study titled, “The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,” was published in the latest issue of the journal International Immunopharmacology.

24 Nov 2020

Sage and perilla herbal teas could help to prevent or treat COVID-19

Researchers in Germany have conducted a study demonstrating the potential antiviral effects of commonly consumed herbal teas on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the pathogen that causes coronavirus disease 2019 (COVID-19).

22 Nov 2020

Study shows how rotavirus leads to severe gastrointestinal disease

Rotavirus is a major cause of diarrhea and vomiting, especially in children, that results in approximately 128,000 deaths annually.

20 Nov 2020

Build-up of cellular 'trash' in the brain can cause neurodegeneration, death

A little mess never killed anyone, right? Wrong. Researchers at Tokyo Medical and Dental University (TMDU) have recently shown that a build-up of cellular "trash" in the brain can actually cause neurodegeneration, and even death.

19 Nov 2020

Scientists identify previously unknown mechanism that drives tumor spread

Any given tumor is composed of a multitude of cell types that can each look or behave differently from its neighbors.

19 Nov 2020

Cannabidiol oils are equally or less effective at inhibiting certain cancer cell lines

Cannabidiol (CBD) oils are equally or less effective at inhibiting the growth of certain cancer cells compared to pure CBD, according to Penn State College of Medicine researchers.

18 Nov 2020

Natural products and herbal medicines show promise in fight against COVID-19

Researchers in China and the United States have called for more research into the potential prophylactic effects of natural products and herbal medicines on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent coronavirus disease 2019 (COVID-19).

17 Nov 2020

Antifungal agent Itraconazole inhibits SARS CoV-2 in vitro

Itraconazole is a broad-spectrum antifungal agent that has been shown to have some in vitro activity against SARS-CoV-2 by a team of Belgian and German researchers.

16 Nov 2020

Affinity-Bead Assisted Mass Spectrometry for Proteomics

In this interview, Ghaith Hamza from AstraZeneca talks to News-Medical Life Sciences about the basic principles of Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS) and how Affi-BAMS can help target specific proteins for proteomic applications.

From Bruker Daltonics 16 Nov 2020

"Cat's claw" extract inhibits replication of SARS-CoV-2 in vitro

Researchers in Columbia and Peru have shown that Uncaria tomentosa – a woody vine native to South America known of as "Cat's claw" – exerts in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

12 Nov 2020