Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Surprising discovery about BH4 may rekindle interest in once-promising pathway

In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.

19 Nov 2018

Researchers find metabolite shuttle between cells in the liver that may combat tissue fibrosis

University of Minnesota Medical School researchers have made a discovery which could lead to a new way of thinking about how disease pathogenesis in the liver is regulated, which is important for understanding the condition nonalcoholic fatty liver disease, which is incredibly common and growing.

16 Nov 2018

Immunity connects gut microbiota and age-related pathologies

EPFL scientists have discovered how a dysfunction in the immune system can cause an overload of a gut bacterium. The bacterium produces excess lactic acid, which in turn triggers the production of reactive oxygen species that cause damage to cells and many age-related pathologies.

13 Nov 2018

Study uncovers link between gut disruption and aging

A new study has shed light on how the disruption of commensal bacteria within the gut can affect the immune system and lead to age-related pathologies.

13 Nov 2018

Scientists grow 3D, beating human heart tissue

Researchers at the University Medical Center Hamburg-Eppendorf have found a way to grow human heart tissue that can serve as a model for the atria of the heart.

8 Nov 2018

VTT, Dyadic to present data highlighting achievements in development of fungal production platform

VTT and Dyadic International, Inc., today announced that VTT scientists will present the excellent results in their collaboration over the past two years at two international conferences: AAPS PharmSci on November 7th in Washington DC and PEGS Europe on November 14th in Lisbon.

5 Nov 2018

Genetic inhibition of SARM1 prevents axonal degeneration in nervous systems

Disarm Therapeutics, a biotechnology company creating a new class of disease-modifying therapeutics for patients with axonal degeneration, a central driver of neurological disease, today announced data demonstrating that genetic inhibition of SARM1 prevents axonal degeneration in the central, ocular and peripheral nervous systems.

5 Nov 2018

NeuroPointDX launches NPDX AA test to identify metabolic subtypes associated with autism

NeuroPointDX, a division of Stemina Biomarker Discovery, today announced the commercial launch of its NPDX AA test, which identifies metabolic subtypes associated with autism spectrum disorder.

1 Nov 2018

Study provides a new way of thinking about cold stress in plants

When temperatures drop, plants can't bundle up. Stuck outside, exposed, plants instead undergo a series of biochemical changes that protect cells from damage.

29 Oct 2018

Scientists find new way to predict obesity-related disease risk

Scientists at Scripps Research and collaborating corporate and academic partners have found a new way to use distinct molecular "signatures" from people with obesity to predict risk of developing diabetes and cardiovascular disease, an advance that could broaden the way doctors and scientists think about diagnosing and treating disease.

12 Oct 2018

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today updated positive results from its Phase 1/2 clinical study of lumasiran, an investigational, subcutaneously administered RNAi therapeutic targeting glycolate oxidase for the treatment of primary hyperoxaluria type 1.

4 Oct 2018

Researchers decode anti-inflammatory mechanism of vitamin E and its metabolites

Vitamin E's positive effects often fail to manifest themselves as strongly as expected, but sometimes administering vitamin E actually has detrimental effects. An international team has now found a possible cause for this.

3 Oct 2018

New approach promises to forecast cultivar resistance at much earlier stage

Bacterial wilt devastates food crops all over the world. It destroys major crop plants such as tomatoes, potatoes, bananas, ginger and pepper. It occurs in many countries and attacks over 200 plant species.

27 Sep 2018

Lancaster professor aims to understand how genes affect smoking cessation

The Canadian Institute of Health Research has awarded $929,475 to Professor Jo Knight of Lancaster Medical School, Lancaster Data Science Institute and the Department of Psychiatry at the University of Toronto.

25 Sep 2018

Potential drugs to treat neurodegenerative diseases garner $3 million grant

A new four-year, $3 million grant will enable Scripps Research scientists to advance compounds that may protect neurons in diseases caused by toxic protein accumulation, including Parkinson's, ALS, Alzheimer's and Creutzfeldt-Jakob disease.

18 Sep 2018

Abnormal levels of metabolites can reliably predict lung disease in 9/11 firefighters

Abnormal levels of more than two dozen metabolites -; chemicals produced in the body as it breaks down fats, proteins and carbohydrates -; can reliably predict which Sept. 11 firefighters developed lung disease and which did not, a new analysis shows.

4 Sep 2018

Researchers develop new approach to treating cancer using enzyme therapy

Researchers at The University of Texas at Austin have developed a new approach to treating cancer using enzyme therapy.

29 Aug 2018

Scientists develop urine diagnostic to detect parasitic worms that cause river blindness

Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.

28 Aug 2018

Chemists synthesize garlic ingredient from readily available components

Fresh garlic extracts contain a variety of healthy organosulfur compounds, among which ajoene forms a major oil-extractable ingredient.

24 Aug 2018

Study uncovers link between gut bacteria and 'hedonic eating'

A study of 63 healthy people showed that those with elevated microbiome levels of the metabolite indole -; produced when gut bacteria break down the amino acid tryptophan -; had stronger function and connectivity in specific areas of the brain's reward network.

24 Aug 2018