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Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

Neural stem cells drive lifelong eye growth in marine bristleworms

A new study, led by the University of Vienna and the Alfred Wegener Institute in Bremerhaven, shows how the eyes of adult marine bristleworms continue to grow throughout life – driven by a ring of neural stem cells reminiscent of vertebrate eyes.

1 Dec 2025

Blocking a ‘gerozyme’ reverses cartilage loss in mice

An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee joints of old mice, a Stanford Medicine-led study has found.

28 Nov 2025

Breakthrough platform reveals the choreography of mammalian transcription

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.

27 Nov 2025

Researchers capture a ribozyme in motion for the first time

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure.

27 Nov 2025

New 10-minute scan shows hidden cause of high blood pressure

A speedy new scan could improve how millions of people with high blood pressure are treated, suggests a new study led by UCL (University College London) researchers.

26 Nov 2025

Researchers uncover how a key transcription factor reads DNA in human cells

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells.

26 Nov 2025

UBC researchers reveal how statins trigger muscle damage

Statins have transformed heart health, saving millions of lives by lowering cholesterol and reducing the risk of heart attacks and strokes.

26 Nov 2025

New imaging method reveals nanodomains inside ALS-linked protein droplets

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

26 Nov 2025

Metformin fails to improve insulin resistance in type 1 diabetes

Metformin treatment in type 1 diabetes lowers insulin dosage but does not improve insulin resistance, highlighting its complex role in diabetes management.

26 Nov 2025

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

25 Nov 2025

How immune signals activate brain circuits to drive sickness-induced social withdrawal

MIT researchers have discovered how an immune system molecule triggers neurons in a specific brain circuit to shut down social behavior in mice modeling infection.

25 Nov 2025

Gut nervous system controls intestinal barrier and allergy risk

An international research team led by scientists from Bern and Charité - Universitätsmedizin Berlin has identified a previously unknown function of the intestinal nervous system.

25 Nov 2025

New skin-permeable polymer delivers insulin without needles

Innovative zwitterionic polymer facilitates insulin absorption through the skin, offering a painless alternative to injections for diabetes management.

25 Nov 2025

Scientists uncover how brain enzyme OTULIN controls tau expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

25 Nov 2025

Deficient ATP release in the brain drives depressive- and anxiety-like behaviors

In a new JNeurosci paper, Tian-Ming Gao and colleagues, from Southern Medical University, explored how adenosine triphosphate (ATP) signaling relates to depression and anxiety using male mice. ATP is a molecule that not only provides energy but also supports communication between neurons.

25 Nov 2025