Immune System News and Research

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Evidence of sustained immune responses weeks after Pfizer-BioNTech BNT162b2 vaccination

A new study published ahead of print in the Clinical Chemistry and Laboratory Medicine (CCLM) journal reports the production of a robust immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using the Pfizer-BioNTech BNT162b2 vaccine. The increase in humoral immunity includes elevated Immunoglobulin G (IgG) and Immunoglobulin A (IgA) levels after the second mRNA dose.

14 Apr 2021

A new polymersome-based SARS-CoV-2 nanovaccine elicits robust immunity

As newer vaccines are being developed to combat the ongoing pandemic of coronavirus disease 2019 (COVID-19), targeting the pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new preprint research paper posted to the bioRxiv server describes a new subunit nanovaccine that appears to have robust immunogenicity and neutralizing activity.

14 Apr 2021

Researchers investigate link between COVID-19 and increased risk of blood clot formation

People who have recovered from COVID-19, especially those with pre-existing cardiovascular conditions, may be at risk of developing blood clots due to a lingering and overactive immune response, according to a study led by Nanyang Technological University, Singapore (NTU) scientists.

13 Apr 2021

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19, has begun.

13 Apr 2021

New discovery offers hope for improving treatments for tuberculosis

The immune response to tuberculosis (TB) differs in adults and newborn babies due to the way immune cells use energy to kick into gear in a bid to kill the bacteria.

13 Apr 2021

COVID-somnia: Americans report increase in sleep problems during the pandemic

The coronavirus pandemic continues to have a negative impact on our sleep, according to new findings from the American Academy of Sleep Medicine.

13 Apr 2021

Could cow's milk provide some passive immunity against COVID-19?

Researchers at the Department of Animal Health, University of Cordoba, Córdoba, Spain, speculate that bovine milk consumption – specifically from cows with resistance to bovine coronaviruses – may potentially provide at least some degree of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The article is available to read in full on the Frontiers in Immunology website.

13 Apr 2021

Measurable antibody response to mRNA COVID-19 vaccine in elderly care home residents

A new preprint research paper posted to the medRxiv* server explores the antibody response to COVID-19 vaccines in elderly residents of nursing homes in the USA. As of March 2021, there have been over 1.4 million infections from SARS-CoV-2 and over 175,000 deaths related to the pandemic among nursing home residents in the country.

13 Apr 2021

Zipper motif mediates SARS-CoV-2 spike trimerization within host cell membrane

A new preprint research paper posted to the bioRxiv* server describes the results of a nuclear magnetic resonance (NMR) study to determine the structure of the S protein transmembrane domain (TMD) and its membrane-proximal regions.

13 Apr 2021

Researchers identify new potential mechanism for age-related macular degeneration

Using laboratory-grown roundworms as well as human and mouse eye tissue, University of Maryland School of Medicine (UMSOM) researchers have identified a new potential mechanism for age-related macular degeneration - the leading cause of blindness among older adults.

13 Apr 2021

Research may lead to a significant breakthrough in the battle against deadly brain tumors

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer.

12 Apr 2021

BGU researchers identify probiotic yogurt-based drug candidates

Researchers at Ben-Gurion University of the Negev (BGU) have for the first time identified new drug candidates based on molecules isolated from probiotic Kefir yogurt for combating pathogenic bacteria and treating various inflammatory conditions, including inflammatory bowel disease (IBD) and COVID-19 related cytokine storms.

12 Apr 2021

Could N protein-based COVID-19 vaccines hinder SARS-CoV-2's NK cell inhibition?

Upon SARS-CoV-2 infection, what are the changes occurring on the surface of the host cell? To address this, and a team of researchers undertook a study exploring the natural killer (NK) cells and their role during a SARS-CoV-2 infection.

12 Apr 2021

COVID19's cytokine storm ushers in a local complement storm in the lungs

A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection.

12 Apr 2021

CD40 drug before surgery can benefit patients with early-stage pancreatic cancer

Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania.

12 Apr 2021

Aneuploidy testing can be key in determining optimal treatment for lung cancer patients

Patients with non-small cell lung cancer (NSCLC) whose cancer cells have low levels of aneuploidy - an abnormal number of chromosomes - tend to respond better to immune checkpoint inhibitor drugs than patients with higher levels, Dana-Farber Cancer Institute researchers will report at the virtual AACR Annual Meeting 2021.

12 Apr 2021

L452R and Y453F SARS-CoV-2 mutations increase transmission and evade immunity

Mutations from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have created multiple variants. Some variants, such as those found in South Africa and Brazil, have caused concern for their potential to evade the immune response. While vaccination efforts are underway, the world is racing against the viruses’ ability to evolve under selective pressure.

11 Apr 2021

Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice

Tick-borne encephalitis is a disease just as nasty as it sounds. Once bitten by an infected tick, some people develop flu-like symptoms that resolve quietly but leave behind rampant neurological disease--brain swelling, memory loss, and cognitive decline.

9 Apr 2021

Hay fever and asthma occur earlier in life and affect more people

The unpopular guests are already here. Hazel-, alder- and elm tree pollen sweep in over us during the early spring months, with birch pollen following in May. Then grass follows in June-July before mugwort pollen closes the season in late summer. All leading to more and more people suffering.

9 Apr 2021

Study points to the involvement of Interleukin 33 in immunity to Sars-CoV-2

Since the beginning of the coronavirus pandemic, scientists and physicians worldwide undertook enormous efforts to understand the disease caused by the virus.

9 Apr 2021

Immune System News and Research

Evidence of sustained immune responses weeks after Pfizer-BioNTech BNT162b2 vaccination

A new polymersome-based SARS-CoV-2 nanovaccine elicits robust immunity

Researchers investigate link between COVID-19 and increased risk of blood clot formation

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

New discovery offers hope for improving treatments for tuberculosis

COVID-somnia: Americans report increase in sleep problems during the pandemic

Could cow's milk provide some passive immunity against COVID-19?

Measurable antibody response to mRNA COVID-19 vaccine in elderly care home residents

Zipper motif mediates SARS-CoV-2 spike trimerization within host cell membrane

Researchers identify new potential mechanism for age-related macular degeneration

Research may lead to a significant breakthrough in the battle against deadly brain tumors

BGU researchers identify probiotic yogurt-based drug candidates

Could N protein-based COVID-19 vaccines hinder SARS-CoV-2's NK cell inhibition?

COVID19's cytokine storm ushers in a local complement storm in the lungs

CD40 drug before surgery can benefit patients with early-stage pancreatic cancer

Aneuploidy testing can be key in determining optimal treatment for lung cancer patients

L452R and Y453F SARS-CoV-2 mutations increase transmission and evade immunity

Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice

Hay fever and asthma occur earlier in life and affect more people

Study points to the involvement of Interleukin 33 in immunity to Sars-CoV-2

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