Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Regenstrief researchers create accurate system for tracking quality of colonoscopies

An accurate system for tracking the quality of colonoscopies and determining the appropriate intervals between these procedures could contribute to both better health outcomes and lower costs. Clinician-researchers from the Regenstrief Institute have created and tested such a system in the nation's first multiple institution colonoscopy quality measurement study utilizing natural language processing and report that it is as accurate but less expensive than human review.

11 Mar 2015

MDC scientists identify new molecular signaling pathway that regulates placental development

During pregnancy, the mother supplies the fetus with nutrients and oxygen via the placenta. If placental development is impaired, this may lead to growth disorders of the embryo or to life-threatening diseases of the mother such as preeclampsia, a serious condition involving high blood pressure and increased urinary protein excretion.

11 Mar 2015

Study supports use of ThyraMIR, ThyGenX Thyroid Oncogene Panel to improve thyroid cancer diagnosis

PDI, Inc. subsidiary, Interpace Diagnostics, announced today new data supporting the use of combination platform testing with ThyraMIR, the first and only microRNA expression classifier, and ThyGenX Thyroid Oncogene Panel, a DNA and RNA mutational analysis, to improve thyroid cancer diagnosis.

11 Mar 2015

Researchers find that weight-loss strategies sorely lacking for individuals with neurological disabilities

A review of nutrition and weight-loss interventions for people with impaired mobility found strategies are sorely lacking for people with neurological disabilities, according to a team of researchers from Case Western Reserve University and Cleveland Clinic.

10 Mar 2015

Researchers take images of tiny molecular machine that bacteria use to infect host cells

Armed with a microscope capable of zooming in on organisms measured in billionths of a meter, scientists report they are the first to observe one of the tiny molecular machines that bacteria use to infect host cells. Findings appear in the Proceedings of the National Academy of Sciences.

10 Mar 2015

Understanding genetic machinery that drives malignant pediatric adrenocortical tumors

In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the "genomic landscape" of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.

10 Mar 2015

Researchers locate, narrow down genes that play role in Type 1 diabetes

The genes that increase the risk of Type 1 diabetes have lost their hiding place.

10 Mar 2015

18F-fluoride PET/MR imaging could diagnose cause of foot pain better than other methods

A single scan could diagnose the cause of foot pain better and with less radiation exposure to the patient than other methods, according to a study in the March 2015 issue of The Journal of Nuclear Medicine.

10 Mar 2015

Advanced Cell Diagnostics' RNAscope technology supports biomarker-selected phase 2 clinical trial of Merrimack Pharmaceuticals' MM-121

Advanced Cell Diagnostics, Inc. (ACD) announced today that Merrimack Pharmaceuticals, Inc. is using ACD's RNAscope technology to select patients for its Phase 2 clinical trial of its product candidate MM-121.

From Advanced Cell Diagnostics 9 Mar 2015

Trained scent dog identifies thyroid cancer in patients’ urine samples

A trained scent dog accurately identified whether patients' urine samples had thyroid cancer or were benign (noncancerous) 88.2 percent of the time, according to a new study, to- be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

9 Mar 2015

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

The St. Jude Children's Research Hospital--Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival.

9 Mar 2015

Myriad Publishes myPath™ Melanoma Pivotal Validation Study in the Journal of Cutaneous Pathology

Myriad Genetics, Inc. (NASDAQ: MYGN) today announced the Journal of Cutaneous Pathology published data from a pivotal clinical validation study that showed the myPath™ Melanoma test is highly effective at differentiating benign skin moles from malignant melanoma with greater than 90 percent diagnostic accuracy. Melanoma is the most dangerous type of skin cancer and more than 76,000 new cases of melanoma are diagnosed each year in the United States.

6 Mar 2015

Better understanding of stomach's response to infection could lead to therapies against gastric damage

A better understanding of the stomach's immune response to Helicobater pylori (H. pylori) infection could lead to new therapies targeting damage in the stomach, report researchers in the March issue of Cellular and Molecular Gastroenterology and Hepatology, the basic science journal of the American Gastroenterological Association.

6 Mar 2015

AAPMD announces "The Silent Airway Problem: Connecting the Dots" conference

The American Academy of Physiological Medicine and Dentistry (AAPMD) is leading the charge for an interdisciplinary medical approach to the diagnosis and treatment of sleep and breathing disorders, which research indicates contribute to a range of serious physiological, cognitive, behavioral and performance conditions in children and adults.

6 Mar 2015

Multimodal approach to distinguish people with autism spectrum disorder

In an ancient Indian parable, a group of blind men touches different parts of a large animal to find what it is. Only when they share the descriptions of an ear, tail, trunk and leg do they know it is an elephant.

6 Mar 2015

Plant molecule helps female mice combat weight gain

A molecule found in some plants can combat weight gain induced by a high-fat diet, but only in female mice, not males. 7,8-dihydroxyflavone (7,8-DHF) is thought to mimic the effects of a growth factor induced by exercise.

6 Mar 2015

Blue Cross Blue Shield of Michigan, UMHS announce new initiative to enhance genetic testing practices

Blue Cross Blue Shield of Michigan and the University of Michigan Health System are collaborating with physicians and laboratories across the state as part of a new initiative to improve genetic testing practices.

5 Mar 2015

Researchers one step closer to unraveling complex processes crucial to sperm development

Researchers are one step closer to unraveling the extraordinarily complex series of processes that leads to an event crucial to human reproduction: the creation of sperm.

5 Mar 2015

Pediatric Cancer Genome Project identifies genetic basis of three pediatric melanoma subtypes

The St. Jude Children's Research Hospital—Washington University Pediatric Cancer Genome Project found that melanoma in some adolescent and adult patients involves many of the same genetic alterations and would likely respond to the same therapy.

5 Mar 2015

Study shows how mutations that cause Alzheimer's disease lead to neurodegeneration, dementia

A study from researchers at Massachusetts General Hospital and Brigham and Women's Hospital reveals for the first time exactly how mutations associated with the most common form of inherited Alzheimer's disease produce the disorder's devastating effects.

5 Mar 2015

Pathology News and Research

Further Reading

Regenstrief researchers create accurate system for tracking quality of colonoscopies

MDC scientists identify new molecular signaling pathway that regulates placental development

Study supports use of ThyraMIR, ThyGenX Thyroid Oncogene Panel to improve thyroid cancer diagnosis

Researchers find that weight-loss strategies sorely lacking for individuals with neurological disabilities

Researchers take images of tiny molecular machine that bacteria use to infect host cells

Understanding genetic machinery that drives malignant pediatric adrenocortical tumors

Researchers locate, narrow down genes that play role in Type 1 diabetes

18F-fluoride PET/MR imaging could diagnose cause of foot pain better than other methods

Advanced Cell Diagnostics' RNAscope technology supports biomarker-selected phase 2 clinical trial of Merrimack Pharmaceuticals' MM-121

Trained scent dog identifies thyroid cancer in patients’ urine samples

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

Myriad Publishes myPath™ Melanoma Pivotal Validation Study in the Journal of Cutaneous Pathology

Better understanding of stomach's response to infection could lead to therapies against gastric damage

AAPMD announces "The Silent Airway Problem: Connecting the Dots" conference

Multimodal approach to distinguish people with autism spectrum disorder

Plant molecule helps female mice combat weight gain

Blue Cross Blue Shield of Michigan, UMHS announce new initiative to enhance genetic testing practices

Researchers one step closer to unraveling complex processes crucial to sperm development

Pediatric Cancer Genome Project identifies genetic basis of three pediatric melanoma subtypes

Study shows how mutations that cause Alzheimer's disease lead to neurodegeneration, dementia

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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