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Newcells Biotech raises additional funding from investors

Newcells Biotech (“Newcells”), a leading drug discovery partner specializing in the development of in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced it has raised a further £1.2 m from existing investors Mercia Ventures, Northstar Ventures and North East Finance.

From Newcells Biotech 8 Dec 2024

Breakthrough discovery in BK polyomavirus replication offers hope for kidney transplant protection

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

6 Dec 2024

Extracellular vesicle DNA regulates immune responses and suppresses liver metastasis

The study highlights how EV-DNA packaging influences immune responses and its promise as a biomarker for assessing colorectal cancer metastasis risk.

6 Dec 2024

Bioengineers develop implantable sensors to monitor inflammation in real time

Proteins are the building blocks of life, and changes in protein levels can indicate improving health or impending illness, including signs of inflammation.

5 Dec 2024

Study sheds light on Kif23's role in embryonic brain development and microcephaly

A team of researchers from Tohoku University, the National Center of Neurology and Psychiatry, and National Yang Ming Chiao Tung University has uncovered a novel molecular mechanism through which Kif23 (a motor protein belonging to the kinesin family) plays a vital role in embryonic brain development.

5 Dec 2024

Coral-inspired bone graft could transform treatment for bone defects

Researchers at Swansea University have developed a revolutionary bone graft substitute inspired by coral which not only promotes faster healing but dissolves naturally in the body after the repair is complete.

5 Dec 2024

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease.

4 Dec 2024

Cancer cells block T-cell activation, but new therapies restore immune defenses

Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment. Restoring balance through PGE2 inhibition and IFN-I enhancement could renew immune defenses and improve immunotherapy outcomes.

4 Dec 2024

SRF awards $230,000 grant to advance research on SYNGAP1-Related Disorders

The SynGAP Research Fund (SRF) has awarded a $230,000 grant to The Jackson Laboratory Rare Disease Translational Center to characterize a mouse model for SYNGAP1-Related Disorders, (SRD), a severe neurodevelopmental disorder marked by seizures, intellectual disabilities, and motor and behavioral challenges.

4 Dec 2024

Study reveals non-invasive technique for early detection of sepsis

Clinicians lack methods for early detection of sepsis, a dysregulated response to infection that can result in life-threatening organ failure if treatment is delayed.

4 Dec 2024

evitria Partners with Sapio Sciences to Streamline Antibody Workflow Management and Reporting

evitria optimizes antibody expression services, enhancing data capture and reporting capabilities for scientific workflows with Sapio's ELN and Report Builder,

From Sapio Sciences 4 Dec 2024

Nanozyme breakthrough offers new hope for viral pneumonia treatment

A recent study in Nature Materials introduces an inhalable nanozyme treatment for viral pneumonia, showing promising results in reducing inflammation and viral load in various mouse models. The nanozyme, CeTA-K1tkP, demonstrates broad-spectrum effects and biocompatibility, offering a potential new approach to treating pneumonia and other inflammatory conditions.

3 Dec 2024

How carrageenan affects insulin resistance

A randomized controlled trial found that carrageenan, a common food additive, may cause subclinical inflammation and insulin resistance in overweight individuals, mediated by gut permeability and inflammation. Effects were linked to BMI but not observed in non-overweight participants during short-term exposure.

3 Dec 2024

Polypurine hairpins found to effectively halt SARS-CoV-2 replication

A study led by the University of Barcelona and the Spanish National Research Council's Institute for Advanced Chemistry of Catalonia (IQAC - CSIC) presents a new therapeutic tool capable of inhibiting the proliferation of the SARS-CoV-2 virus that causes COVID-19.

3 Dec 2024

New food-grade natural solution created for tackling obesity

As obesity rates continue to rise, many are turning to prescription medicines like Ozempic for weight loss. But with significant side effects, accessibility and cost issues, alternatives are needed.

2 Dec 2024

Natural polyphenol boosts mitochondrial function and muscle performance during aging

Oleuropein enhances mitochondrial calcium uptake, reversing age-related declines in muscle function and energy metabolism, with promising clinical potential.

2 Dec 2024

Fibroblastic reticular cells power immune defenses in lung cancer

Fibroblastic reticular cells (FRCs) create T-cell-supportive niches within lung cancer tumors, facilitating T-cell migration, clustering, and activation. This study highlights FRCs' potential as therapeutic targets to boost anti-tumor immunity in non-small cell lung cancer (NSCLC).

1 Dec 2024

in vivo News and Research

Newcells Biotech raises additional funding from investors

Breakthrough discovery in BK polyomavirus replication offers hope for kidney transplant protection

Extracellular vesicle DNA regulates immune responses and suppresses liver metastasis

Bioengineers develop implantable sensors to monitor inflammation in real time

Study sheds light on Kif23's role in embryonic brain development and microcephaly

Coral-inspired bone graft could transform treatment for bone defects

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Cancer cells block T-cell activation, but new therapies restore immune defenses

SRF awards $230,000 grant to advance research on SYNGAP1-Related Disorders

Study reveals non-invasive technique for early detection of sepsis

evitria Partners with Sapio Sciences to Streamline Antibody Workflow Management and Reporting

Nanozyme breakthrough offers new hope for viral pneumonia treatment

How carrageenan affects insulin resistance

Polypurine hairpins found to effectively halt SARS-CoV-2 replication

New food-grade natural solution created for tackling obesity

Natural polyphenol boosts mitochondrial function and muscle performance during aging

Fibroblastic reticular cells power immune defenses in lung cancer

Quabodepistat combo shows promise for safer, faster tuberculosis treatment

Phase 1 study finds serine- and glycine-free diet boosts immune response in colorectal cancer

RNA enzyme found key to heart cell energy shift after birth

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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