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Researchers conduct an international study of vaccine hesitancy

The health beliefs model is one method of quantifying health behaviors. In a study recently published in the journal Vaccine, this method is utilized to specifically study COVID-19 vaccine hesitancy, bearing in mind that hesitancy is highly variable not only between individuals and location but also in regards to the specific medicine in question.

30 Aug 2021

Antisense oligonucleotides engineered to inhibit SARS-CoV-2

In a paper recently uploaded to the bioRxiv* preprint server, structure-based ASOs are developed against SARS-CoV-2, intended to bond with RNA in its structured in situ form, rather than the more rarely encountered linear section, achieving greater affinity and specificity than linear ASOs, and demonstrating inhibition of virus replication in human cells.

30 Aug 2021

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Self-amplifying RNA (saRNA) is an advanced platform for nucleic acid vaccine development. The backbone is typically derived from an alphaviral genome and encodes a gene of interest (GOI) and a viral replicase that can amplify the genomic and subgenomic RNA.

30 Aug 2021

Next-gen COVID vaccine to make persistent neutralizing antibodies

Presently, there is a need to develop improved versions of COVID-19 vaccines that are effective against the SARS-CoV-2 variants of concern (VOC) and can confer long-term protection. Considering the need of the hour, scientists from the University of Sydney in Australia have generated a new COVID-19 vaccine CoVac-II and evaluated its effect against COVID-19 strains. The findings from this study are published on the bioRxiv* preprint server while awaiting peer review.

30 Aug 2021

Cognitive function of older adults could be improved through multidomain lifestyle interventions

Aging-US published "Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial" which reported that in an outcome assessor-blinded, randomized controlled trial, participants without dementia and with one or more modifiable dementia risk factors, aged 60-79 years, were randomly assigned to the facility-based MI, the home-based MI, or the control group receiving general health advice.

28 Aug 2021

'Humanized' mouse model beats current approaches for finding the best organ donor

A "humanized" mouse model equipped with the immune system of a patient who needs an organ transplant beats current measures for identifying the best potential living donor, scientists report.

27 Aug 2021

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

The AIDS Clinical Trials Group, the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies.

27 Aug 2021

Olympus Announces First Organoid Conference to Support Stem Cell Research

Olympus is proud to announce its first Olympus Organoid Conference—Think Deep, See Deeper, which will be held virtually on Sept. 7–9, 2021.

From Evident Corporation - Life Sciences 27 Aug 2021

COVID-19 vaccine potency has diminished in recent months, but still helps in saving lives

COVID-19 vaccines remain effective, but their potency has diminished in recent months, according to a nationwide study at eight sites, including Salt Lake City, Utah.

27 Aug 2021

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

A Phase 2 trial led by City of Hope, a world-renowned research and treatment center for cancer and diabetes, suggests that adding the novel ataxia telangiectasia and Rad3-related (ATR) inhibitor drug berzosertib to standard-of-care chemotherapy for patients with metastatic urothelial cancer does not extend progression-free survival.

27 Aug 2021

Study assesses the use of complementary and integrative healthcare by people with spinal cord injury

In a cross-sectional self-report study led by experts from five Spinal Cord Injury Model Systems Centers, a survey of people with spinal cord injury revealed that 80 percent of participants were current or previous users of complementary and integrative healthcare approaches such as multivitamins, massage, and acupuncture.

26 Aug 2021

Preliminary study suggests nitric oxide may be a potential treatment for COVID-19 respiratory failure

New research led by Devang K. Sanghavi of the Mayo Clinic in Florida, USA, suggests pre-intubation use of nitric oxide for patients with COVID-19–related hypoxemic respiratory may help reduce patients' mortality. Their findings show that inhaling nitric oxide in this patient population could reduce the need for future intubation and other invasive mechanical ventilation.

26 Aug 2021

Large UK study examines impact of Delta variant on viral burden and vaccine effectiveness

Now, a new study published on the medRxiv* preprint server focused on determining the effectiveness of the BNT162b2, ChAdOx1, and mRNA-1273 vaccines by conducting SARS-CoV-2 PCR-positive tests.

26 Aug 2021

Researchers receive $14 million grant to study the effectiveness of hydrocephalus treatment

Patients diagnosed with idiopathic normal pressure hydrocephalus (iNPH), a type of brain swelling most commonly seen in older adults — and for which the underlying cause is unknown — are typically treated by surgically installing a shunt (drain) to remove the excess fluid associated with the condition.

26 Aug 2021

Could soluble CD24 offer some hope against severe COVID-19?

A recent randomized phase III trial conducted by researchers at the Ohio State University, Columbus, OH, US, evaluated the impact of CD24Fc in severe COVID-19 patients and showed promising clinical efficacy. This study is available as a preprint on the medRxiv* server.

26 Aug 2021

Portable MRI can help identify intracranial hemorrhages in stroke patients

When patients exhibit stroke symptoms, doctors must quickly make a life or death determination: Are their symptoms caused by a clot that can be treated with blood thinners or by bleeding in the brain, which may require surgery?

25 Aug 2021

Higher SARS-CoV-2 Delta variant transmission among K-12 schoolchildren can be reduced by interventions, says study

A new study reports the results of a model framed to explore the transmission of the delta variant among schoolchildren and the most effective intervention methods to minimize such spread.

25 Aug 2021

Can the spread of COVID-19 infection be mitigated through a strict vaccination strategy within 100 days?

A new study evaluates the new COVID-19 policy implemented in NSW.

25 Aug 2021

Analysis of antibody titer decay following vaccination or SARS-CoV-2 infection

A new study focused on the decrease in antibody titers following two doses of BNT162b2 vaccine or SARS-CoV-2 natural infection in Israel.

25 Aug 2021

Scientists forecast healthcare burden of future COVID waves

The findings indicate that given the lower vaccine efficacy against the SARS-CoV-2 delta variant, France may face a large epidemic wave infecting 25% of the general population even with a 95% vaccine coverage. This, in turn, could affect the healthcare system in terms of hospital bed occupancy. The study is currently available on the medRxiv* preprint server.

25 Aug 2021

Efficacy News and Research

Researchers conduct an international study of vaccine hesitancy

Antisense oligonucleotides engineered to inhibit SARS-CoV-2

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Next-gen COVID vaccine to make persistent neutralizing antibodies

Cognitive function of older adults could be improved through multidomain lifestyle interventions

'Humanized' mouse model beats current approaches for finding the best organ donor

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

Olympus Announces First Organoid Conference to Support Stem Cell Research

COVID-19 vaccine potency has diminished in recent months, but still helps in saving lives

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

Study assesses the use of complementary and integrative healthcare by people with spinal cord injury

Preliminary study suggests nitric oxide may be a potential treatment for COVID-19 respiratory failure

Large UK study examines impact of Delta variant on viral burden and vaccine effectiveness

Researchers receive $14 million grant to study the effectiveness of hydrocephalus treatment

Could soluble CD24 offer some hope against severe COVID-19?

Portable MRI can help identify intracranial hemorrhages in stroke patients

Higher SARS-CoV-2 Delta variant transmission among K-12 schoolchildren can be reduced by interventions, says study

Can the spread of COVID-19 infection be mitigated through a strict vaccination strategy within 100 days?

Analysis of antibody titer decay following vaccination or SARS-CoV-2 infection

Scientists forecast healthcare burden of future COVID waves

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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