Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

No one-size-fits-all AI program exists for all preventive treatments

A Rutgers analysis of dozens of artificial intelligence (AI) software programs used in precision, or personalized, medicine to prevent, diagnose and treat disease found that no program exists that can be used for all treatments.

18 Aug 2022

Researchers develop a novel method to screen publicly available raw WGS data of SARS-CoV-2

Researchers developed a novel method to screen publically available raw whole genome sequencing data of SARS-CoV-2 and identify mutations of interest more rapidly.

18 Aug 2022

New technique keeps the cells alive during RNA extraction

RNA sequencing allows scientists to study the expression of genes in a cell. Since messenger RNA (mRNA) is generated from a DNA gene, that information can be used to identify the original gene sequence and thus measure the activity of thousands of genes (i.e. the transcriptome) in these cells.

17 Aug 2022

KAUST bioscientists develop new method to study the bone marrow microenvironment in greater detail

Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.

16 Aug 2022

Computational pipeline for the early identification of emerging SARS-CoV-2 variants

Researchers developed a computational pipeline for the early identification of emerging SARS-CoV-2 variants of interest by analyzing SARS-CoV-2 genome data and allocating risk scores on the basis of functional and epidemiological parameters.

16 Aug 2022

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases.

12 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Gene expression in male and female brains become more similar with age, study says

When male and female fruit flies age, their brains become desexualized. Age-related changes take place in both sexes, but the male brain becomes feminized to a larger extent than the female brain becomes masculinized. This is the conclusion of a study performed by a research group at Linköping University. The findings are published in the journal Proceedings of the Royal Society of London B.

11 Aug 2022

Traditional Chinese medicine reduces severity of radiation-induced gastrointestinal mucositis in rats

For tens of thousands of Australians who receive radiotherapy as part of their cancer treatment, mucositis is a serious side effect that may cause inflammation, ulcers, diarrhea, nausea and vomiting, abdominal pain and bloating.

11 Aug 2022

Research reveals a gut-brain pathway that contributes to the development of Alzheimer’s disease

Research led by Drs. Yuhai Zhao and Walter J Lukiw at the LSU Health New Orleans Neuroscience Center and the Departments of Cell Biology and Anatomy, Neurology and Ophthalmology, reports for the first time a pathway that begins in the gut and ends with a potent pro-inflammatory toxin in brain cells contributing to the development of Alzheimer's disease (AD).

9 Aug 2022

Novel AI tools accurately predict the role of DNA’s regulatory elements

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA's regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

9 Aug 2022

Proof-of-concept model uses AI to combine multiple types of data to predict cancer outcomes

While it's long been understood that predicting outcomes in patients with cancer requires considering many factors, such as patient history, genes and disease pathology, clinicians struggle with integrating this information to make decisions about patient care.

8 Aug 2022

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

In a potential game changer for patients with type 2 diabetes, a team of researchers at the Diabetes, Obesity, and Metabolism Institute (DOMI) at the Icahn School of Medicine at Mount Sinai has identified a therapeutic target for the preservation and regeneration of beta cells (β cells) - cells in the pancreas that produce and distribute insulin.

4 Aug 2022

CHOP helps launch new computational platform to harmonize pediatric cancer data

Children's Hospital of Philadelphia has helped launch a new computational platform that will harmonize pediatric cancer data, allowing researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.

4 Aug 2022

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Investigators from Cedars-Sinai Cancer have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy.

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN Bio 3 Aug 2022

International travel restrictions were a key intervention for slowing COVID-19 spread, study shows

A study of COVID-19 variant transmission into and across Canada shows that international travel restrictions were a key intervention for reducing or slowing spread, according to a report published today in eLife.

2 Aug 2022

Prenatal opioid exposure may cause long-term neurological or behavioral effects later in a child's life

While infants exposed to opioids during their mother's pregnancy have been linked to adverse health outcomes, a new study at the University of Missouri has found prenatal opioid exposure could trigger long-term neurological or behavioral effects later in a child's life.

29 Jul 2022

Automation of established method for isolating volatile food ingredients

A research team from the Leibniz Institute for Food Systems Biology at the Technical University of Munich (LSB) has succeeded in automating an established method for the gentle, artifact-avoiding isolation of volatile food ingredients.

29 Jul 2022

Nonfungible tokens may help overcome the ethical challenges for secondary use of biospecimens

JMIR Publications recently published "Nonfungible Tokens as a Blockchain Solution to Ethical Challenges for the Secondary Use of Biospecimens: Viewpoint" in JMIR Bioinformatics and Biotechnology in which the authors discuss how current practices of de-identifying human samples for research is reminiscent of the treatment of Henrietta Lacks's tissue in 1951.

29 Jul 2022

Bioinformatics News and Research

Further Reading

No one-size-fits-all AI program exists for all preventive treatments

Researchers develop a novel method to screen publicly available raw WGS data of SARS-CoV-2

New technique keeps the cells alive during RNA extraction

KAUST bioscientists develop new method to study the bone marrow microenvironment in greater detail

Computational pipeline for the early identification of emerging SARS-CoV-2 variants

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Novel model reveals how genomic instability arises in histologically benign tissue

Gene expression in male and female brains become more similar with age, study says

Traditional Chinese medicine reduces severity of radiation-induced gastrointestinal mucositis in rats

Research reveals a gut-brain pathway that contributes to the development of Alzheimer’s disease

Novel AI tools accurately predict the role of DNA’s regulatory elements

Proof-of-concept model uses AI to combine multiple types of data to predict cancer outcomes

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

CHOP helps launch new computational platform to harmonize pediatric cancer data

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

International travel restrictions were a key intervention for slowing COVID-19 spread, study shows

Prenatal opioid exposure may cause long-term neurological or behavioral effects later in a child's life

Automation of established method for isolating volatile food ingredients

Nonfungible tokens may help overcome the ethical challenges for secondary use of biospecimens

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