Proteomics News and Research

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The term 'proteome' was first coined in 1994, and refers to all the proteins in a cell, tissue, or organism. Proteomics refers to the study of the proteome. Because proteins are involved in almost all biological activities, the proteome is a rich source of biological information.

Researchers examine SARS-CoV-2 RNA interactome

A new study focuses on the identification of RNA-binding protein by mass spectrometry (ChIRP-M/S) approach. This study develops a global map that contains the complete set of host proteins that involve the SARS-CoV-2 genome during infection. This study has successfully identified new SARS-CoV-2 host dependency factors by merging proteomics data with gene silencing experiments. Such a discovery has paved new roads to develop more antiviral therapies.

25 Mar 2021

Researchers discover a novel marker of adult human neural stem cells

The mammalian center for learning and memory, hippocampus, has a remarkable capacity to generate new neurons throughout life. Newborn neurons are produced by neural stem cells (NSCs) and they are crucial for forming neural circuits required for learning and memory, and mood control.

24 Mar 2021

How could AI be used to predict infection outcomes?

Professor Frankel speaks to News-Medical about his latest research that investigated whether AI could be used to predict infection outcomes.

23 Mar 2021

Joint project aims to establish automated system for SARS-CoV-2 analysis in wastewater

On March 19, 2021, Hokkaido University, Robotic Biology Institute Inc., iLAC Co., Ltd., and Shionogi & Co., Ltd. have entered into a memorandum of understanding (MOU) toward the establishment of an automated system for the analysis of the novel coronavirus (SARS-CoV-2) in wastewater.

20 Mar 2021

New proteomics method helps confirm COVID-19 transmission from mother to fetus

Researchers from Skoltech were part of a research consortium studying a case of vertical COVID-19 transmission from mother to her unborn child that resulted in major complications in the pregnancy, premature birth and death of the child.

19 Mar 2021

INTEGRA’s electronic pipettes eliminate user fatigue and improve pipetting productivity

CDI Labs – a biotechnology company based in Puerto Rico – is using INTEGRA’s VIAFLO and VOYAGER electronic pipettes to streamline workflows and improve accuracy for the development of next generation proteomics products.

From INTEGRA Biosciences 17 Mar 2021

Researchers identify epigenetic mechanism responsible for lifelong stress susceptibility

An epigenetic modification that occurs in a major cell type in the brain's reward circuitry controls how stress early in life increases susceptibility to additional stress in adulthood, researchers at the Icahn School of Medicine at Mount Sinai have learned.

15 Mar 2021

Which biomarkers can help predict severe COVID-19?

The ability to detect potentially fatal illness early on in the course of the disease would enable a swift prioritization of these high-risk individuals for treatment. A new preprint on the medRxiv* server presents an array of biomarkers that may help achieve this laudable goal.

15 Mar 2021

Proteomics shows SARS-CoV-2 NSP7 and NSP8 forms stable dimeric unit

A new preprint, released on the bioRxiv* preprint server, describes the structure of part of the dynamic protein-RNA complex known as the replication-transcription complex (RTC), which is crucial in the replication of the large ribonucleic acid (RNA) genome of this virus.

9 Mar 2021

Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

At the virtual 17th US HUPO Conference (US HUPO 2021), Bruker Corporation (Nasdaq: BRKR) today announces progress with several collaborations in deep, unbiased plasma proteomics, leveraging the speed, sensitivity and dynamic range of 4D proteomics on timsTOF Pro systems.

From Bruker Daltonics 9 Mar 2021

Novel bioinformatics tool could help improve COVID-19 diagnosis

An interesting new study by researchers at the University of Liverpool, University of Bristol and Public Health England in the UK describes a novel bioinformatics tool used to detect subgenomic messenger ribonucleic acid (mRNA) sequences from the virus. This may help develop new diagnostic tools and model the transmission of the virus.

8 Mar 2021

Proteomics analysis from aggressive human cancers can help identify potential therapeutic targets

Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets.

4 Mar 2021

The Role of D-Amino Acids in Humans

In this interview, Dr. Daniel Armstrong from the University of Texas at Arlington talks to News-Medical Life Sciences about his upcoming Pittcon presentation.

From Pittcon 4 Mar 2021

New Nature Communications publication by Mann & Theis Groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics

Bruker Corporation today announces a seminal publication from the groups of Professors Matthias Mann and Fabian Theis in the journal Nature Communications with the title ‘Deep learning the collisional cross sections of the peptide universe from a million experimental values’ by Florian Meier et al.

From Bruker Daltonics 4 Mar 2021

Analytical Mass Spectrometry: How Did We Get Here, Where are We Going?

News-Medical interviews Rick Yost, winner of the Pittsburgh Analytical Chemistry Award 2021, about his research into mass spectrometry.

From Pittcon 3 Mar 2021

Some types of fat are more resistant to weight loss, shows study

Scientists have mapped out what happens to fat deposits during intermittent fasting (every second day), with an unexpected discovery that some types of fat are more resistant to weight loss.

3 Mar 2021

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation.

28 Feb 2021

COVID-19 may alter host proteins to cause autoimmunity

To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.

23 Feb 2021

Mucosal delivery of IFNs a good strategy for COVID-19 prophylaxis post-exposure

Researchers from the UK and Germany recently reported a comprehensive characterization of the SARS-CoV-2 response of human nasal epithelial cells, revealing a response dominated by IFN-I/IIIs. Also, recombinant IFN-I/III treatment was found to efficiently block the replication of SARS-CoV-2, which suggests that mucosal delivery of IFNs may be a good strategy for prophylaxis post-exposure.

22 Feb 2021

Researchers test the therapeutic efficacy of potential COVID-19 interventions in mouse models

Aarthi Narayanan, Associate Professor, and Lance Liotta, Co-Director, Center for Applied Proteomics and Molecular Medicine, are conducting three studies to assess the therapeutic efficacy of candidate interventions for COVID-19 in mouse models.

20 Feb 2021