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The Surgeon-Scientist Pioneering Regenerative Engineering

In this interview, Sir Prof. Cato T. Laurencin, the 2025 Coulter Lecturer, discusses how he is addressing today’s medical challenges using the technology of the future.

From Pittcon 5 May 2025

Where and why men die younger: global data breaks it down

A global study published in PLOS Medicine examined sex-disaggregated data on hypertension, diabetes, and HIV/AIDS across 204 countries. It revealed significant but context-dependent differences in disease burden, care access, and outcomes between males and females.

4 May 2025

Semaglutide clears liver inflammation and cuts fibrosis in MASH patients, trial shows

A phase 3 trial shows that once-weekly semaglutide significantly improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH). The interim results also reveal meaningful weight loss and improved cardiometabolic markers, with a favorable safety profile.

4 May 2025

Gene-edited immune cells show promise against advanced GI cancers

Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers.

3 May 2025

Medicaid unwinding may have put opioid recovery care at risk

The massive national effort to return the Medicaid enrollment process to its pre-pandemic rules starting in April 2023 may have disrupted the care of people receiving treatment for opioid addiction, a new University of Michigan study suggests.

3 May 2025

Rising antibiotic resistance threatens UTI treatment in Malawi

A growing resistance to antibiotics is complicating the treatment of urinary tract infections (UTIs) in Malawi, with new research revealing that nearly half of women presenting with symptoms at a major referral hospital had infections resistant to multiple drugs.

3 May 2025

New gene editing tool enables precise control of mitochondrial mutation load

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes.

3 May 2025

Study shows brain estrogen directly regulates appetite in mice

Researchers in Japan found that estrogen produced within the brain, called neuroestrogen, suppresses appetite and reduces body weight in mice by enhancing MC4R expression. The study also showed that neuroestrogen boosts leptin sensitivity, suggesting new targets for obesity treatment.

2 May 2025

Stenting improves long term outcomes in CTO PCI patients

In patients undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI), stenting demonstrated improved long-term survival and fewer cardiac arrests at one year.

2 May 2025

Heat triggers sperm activation for fertilization in mammals

In mammals - including us humans - sperm are surprisingly picky about temperature, thriving best in conditions a few degrees cooler than normal body temperature.

2 May 2025

Medicaid rollbacks could deepen health inequities

A new analysis provides evidence that reductions in access to Medicaid could increase deaths and cause financial hardship to people currently covered under an expansion of Medicaid that was implemented under the Affordable Care Act (ACA).

2 May 2025

Study uncovers how a mobile genetic element hijacks human cells

Viruses are known to use the genetic machinery of the human cells they invade to make copies of themselves. As part of the process, viruses leave behind remnants throughout the genetic material (genomes) of humans.

2 May 2025

New studies link increased heart disease risk to tobacco and cannabis use

New clinical results from multiple studies show coronary heart disease death associated with tobacco use is anticipated to rise up to 40% in the next five years and people with cannabis use disorder are 50% more likely to experience cardiogenic shock, acute myocardial infarction, and arrhythmias.

2 May 2025

Lysosomal lipid peroxidation drives ferroptosis in cancer cells

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

2 May 2025

Study uses artificial intelligence to classify patient pain archetypes after knee replacement

A study using artificial intelligence to classify patient pain archetypes and identify risk for severe pain after knee replacement has earned a Best of Meeting award at the 50th Annual Meeting of the American Society of Regional Anesthesia and Pain Medicine.

2 May 2025

ZIP4 protein identified as driver of glioblastoma aggression

In a study published Wednesday in the Proceedings of the National Academy of Sciences (PNAS), University of Oklahoma researchers detail their discoveries about why the brain tumor glioblastoma is so aggressive.

2 May 2025

New drug technique targets gut inflammation with precision

A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments.

2 May 2025

Plasma activated medium shows promise against synovial sarcoma

Plasma-activated medium (PAM) shows tumor-fighting effects against the rare form of cancer known as synovial sarcoma, an Osaka Metropolitan University-led research team has found.

2 May 2025

Sapio Sciences introduces Biorepository Management solution in Sapio Release 25.4

Sapio Sciences, the science-aware™ lab informatics platform, today announced Sapio Release 25.4, introducing a new Biorepository Management solution, enhanced sample management capabilities, and platform-wide enhancements designed to streamline lab operations and support high-throughput research environments.

From Sapio Sciences 2 May 2025