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New molecule extracted from the leaves of chestnut tree neutralizes staph bacteria

Scientists isolated a molecule, extracted from the leaves of the European chestnut tree, with the power to neutralize dangerous, drug-resistant staph bacteria. Frontiers in Pharmacology published the finding, led by scientists at Emory University.

28 Jun 2021

Preliminary results of AAV-mediated gene therapy for Crigler Najjar syndrome

Preliminary results from the European gene therapy trial for Crigler-Najjar syndrome, conducted by Genethon in collaboration with European network CureCN, were presented at the EASL (European Association for the Study of the Liver) annual International Liver Congress on June 26.

28 Jun 2021

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

A new review of the emerging variants of concern (VOCs) of the SARS-CoV-2, which has caused the COVID-19 pandemic, shows that there is a major need to constantly re-evaluate the utility of existing therapeutics and vaccines against the virus and to develop new ones.

28 Jun 2021

Study examines effect of sorafenib in patients with advanced hepatocellular carcinoma

Oncotarget published "Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib" which reported that this study investigated the association of the IGF/CTP score with overall survival and progression-free survival of HCC patients treated with sorafenib.

28 Jun 2021

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

28 Jun 2021

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

Mutation-signature–associated metrics predict cancer progression in patients

Oncotarget published "Predicting clinical outcomes using cancer progression associated signatures" which reported somatic mutation signatures are an informative facet of cancer etiology, however they are rarely useful for predicting patient outcome.

28 Jun 2021

Tocilizumab and sarilumab shown to be effective in critical COVID-19

A new study, released as a preprint on the medRxiv* server, describes how a team of researchers from the University Medical Center Utrecht in the Netherlands explored the efficacy of four monoclonal antibodies that antagonize powerful pro-inflammatory pathways. The team sought to determine which were useful in treating critically ill COVID-19 patients on organ support.

28 Jun 2021

Oxford-AstraZeneca COVID-19 vaccine induces robust T cell-based immunity

A recent study conducted by an international team of scientists has revealed that the Oxford-AstraZeneca coronavirus disease 2019 (COVID-19) vaccine, AZD1222, is capable of inducing strong spike-specific CD4+ T cell helper type 1 (Th1) and CD8+ T-cell responses in vaccinated individuals. A detailed description of AZD1222-induced cellular immunity is currently available on the medRxiv* preprint server.

28 Jun 2021

Why SARS-CoV-2 delta variant is more infectious

German experts recently explained why the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant is more infectious and pathogenic than its ancestor. By conducting a series of in vitro experiments, they have revealed that increased ability to induce cell-to-cell fusion (syncytia) and reduced susceptibility to vaccine and infection-induced antibodies make the delta variant more infectious than previously circulating variants. The study is currently available on the bioRxiv* preprint server.

28 Jun 2021

An oral pill for COVID-19? Molnupiravir shows promise

Recently, researchers reported molnupiravir as the first oral and direct-acting antiviral that is highly effective at reducing SARS-CoV-2 levels.

27 Jun 2021

Oxford study sheds light on level of antibodies needed to protect against COVID-19 symptoms

Researchers in the UK have reported on the relationship between humoral (antibody) responses and protection against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following immunization with AstraZeneca’s ChAdOx1 vaccine.

27 Jun 2021

Lambda lineage of SARS-CoV-2 has potential to become variant of concern

Researchers have described the first reported infection with the C.37 (Lambda) lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Southern Brazil.

27 Jun 2021

Yeast-derived polysaccharide mixture effectively inhibits the onset, progression of immune disorders

The development of therapeutic drugs for inflammatory bowel disease, an intractable immune disease, and multiple sclerosis - an autoimmune disorder - is gaining traction.

25 Jun 2021

Novel biosensor offers rapid quantitative variant of concern-independent serology for SARS-CoV-2

Even as herculean efforts are being made to extend the reach of vaccination against COVID-19 to all the regions of the world, there is a dire need for rapid and sensitive tests to assess the antibody response to the various vaccines used and to monitor antibody titers over time. A new preprint describes a new approach to this problem which could be applied to other molecules of interest as well, both in laboratories and at the point of care.

25 Jun 2021

Study examines safety of COVID-19 vaccination during lactation

A new preprint, recently released on the medRxiv* server, reports from real life in a cohort of mother-child dyads in Singapore. The mothers were lactating after having received COVID-19 vaccination.

25 Jun 2021

Pronation maneuvers for critically ill COVID-19 patients - multidisciplinary management reduce complications

A recent study aimed to determine the efficacy of pronation maneuvers by the ICU physiotherapy team when used on critically ill COVID-19 patients.

24 Jun 2021

Mask-wearing reduces COVID-19 transmission significantly, study finds

Researchers from the University of Bristol found that an entire population that wears masks in public leads to a reduction in the transmission of SARS-CoV-2 by almost 26%.

24 Jun 2021

Could polio vaccines induce cross-reactive antibodies that target SARS-CoV-2?

A new preprint released on the medRxiv* server explores a link between immunity to SARS-CoV-2, the earlier SARS-CoV, and childhood poliovirus vaccination. Almost 90% of the world’s people have received this vaccine, but antibodies elicited by it reduce over time and are almost absent at the end of adolescence.

24 Jun 2021

New tablet-sized device can profile multiple COVID-19 antibodies and biomarkers simultaneously

Biomedical engineers at Duke University in the USA have developed a device that detects coronavirus disease (COVID-19) antibodies as well as biomarkers that distinguish between antibodies produced in response to SARS-CoV-2 and four other coronaviruses with complete accuracy.

24 Jun 2021

Efficacy News and Research

New molecule extracted from the leaves of chestnut tree neutralizes staph bacteria

Preliminary results of AAV-mediated gene therapy for Crigler Najjar syndrome

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

Study examines effect of sorafenib in patients with advanced hepatocellular carcinoma

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Mutation-signature–associated metrics predict cancer progression in patients

Tocilizumab and sarilumab shown to be effective in critical COVID-19

Oxford-AstraZeneca COVID-19 vaccine induces robust T cell-based immunity

Why SARS-CoV-2 delta variant is more infectious

An oral pill for COVID-19? Molnupiravir shows promise

Oxford study sheds light on level of antibodies needed to protect against COVID-19 symptoms

Lambda lineage of SARS-CoV-2 has potential to become variant of concern

Yeast-derived polysaccharide mixture effectively inhibits the onset, progression of immune disorders

Novel biosensor offers rapid quantitative variant of concern-independent serology for SARS-CoV-2

Study examines safety of COVID-19 vaccination during lactation

Pronation maneuvers for critically ill COVID-19 patients - multidisciplinary management reduce complications

Mask-wearing reduces COVID-19 transmission significantly, study finds

Could polio vaccines induce cross-reactive antibodies that target SARS-CoV-2?

New tablet-sized device can profile multiple COVID-19 antibodies and biomarkers simultaneously

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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