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Dopamine treatment can reduce Alzheimer's plaques and improve memory

A new way to combat Alzheimer's disease has been discovered by Takaomi Saido and his team at the RIKEN Center for Brain Science (CBS) in Japan.

6 Aug 2024

New compound ZTA-26 could be a game-changer in lipid metabolism regulation

Scientists at Nagoya University in Japan have made a significant breakthrough in treating lipid disorders.

6 Aug 2024

Breakthrough MS drug uses green mamba venom discovery to promote myelin repair

Ten years of work, and a little help from the green mamba snake, has resulted in a promising new drug that is already being tested in clinical trials.

5 Aug 2024

New dual-purpose contrast agent revolutionizes PET and MRI integration for enhanced diagnosis

A research team from IOCB Prague, working in collaboration with the University of Tübingen, Germany, and the Faculty of Science, Charles University, has developed a new type of contrast agent that can be used in both magnetic resonance imaging (MRI) and positron emission tomography (PET).

5 Aug 2024

Novel antibiotic compound shows promise against drug-resistant bacteria and flesh-eating infections

Researchers at Washington University School of Medicine in St. Louis have developed a novel compound that effectively clears bacterial infections in mice, including those that can result in rare but potentially fatal "flesh-eating" illnesses.

2 Aug 2024

Study explores interplay between bone, adrenal glands, and aging

Figuring out how the tissues in our bones, adrenal glands, muscle and fat "talk" to each other could help scientists better understand what happens to our skeletons with age, when our bones tend to lose mass and become weaker, leaving us at risk for falls and fractures.

1 Aug 2024

Study reveals serotonin's role in ependymoma tumor growth

Do neurons play a role in brain tumor growth and development? Scientists at St. Jude Children's Research Hospital and Baylor College of Medicine have evidence showing that, for childhood ependymomas, they do.

31 Jul 2024

Genetic loss of miR-205 boosts mammary gland development in mice, reveals new insights into breast cancer suppression

Genetic loss of miR-205 in mice enhances mammary gland development and branching, challenging previous lethality findings and highlighting its onco-suppressive functions.

30 Jul 2024

Cordyceps sinensis shown to alleviate idiopathic pulmonary fibrosis in mice

A recent study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

25 Jul 2024

Researchers identify a potential therapeutic target for advanced multiple sclerosis

Researchers from Kyushu University have identified a potential therapeutic target for the treatment of advanced multiple sclerosis (MS), a potentially disabling condition associated with the central nervous system.

25 Jul 2024

Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

TMDU researchers demonstrate proof of concept of antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies.

25 Jul 2024

Creating the first genetically susceptible mice for late-onset Alzheimer's

Mice don't get Alzheimer's - and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments.

24 Jul 2024

Oligodendrocytes identified as key source of amyloid beta in Alzheimer's disease

Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024 in the open-access journal PLOS Biology by Rikesh Rajani and Marc Aurel Busche from the UK Dementia Research Institute at University College London, and colleagues.

23 Jul 2024

Epigenetic insights into stroke-induced immunological changes

A stroke not only causes acute damage to the brain, but can also have long-term health implications for other organs - such as the heart.

23 Jul 2024

Revolutionary ATP imaging technique sheds light on kidney cell energy production

The prevalence of kidney disease has been increasing in Japan, with it now affecting one in eight adults, but developing effective treatment remains a challenge.

23 Jul 2024

New study sheds light on irregular heartbeat risk

Two new, basic animal research studies shed light on alcohol consumption and the heart. The first study may help explain why binge drinking sometimes causes an irregular heartbeat and a possible way to prevent it. The second study investigated why alcohol may have a negative impact on heart function in women taking estrogen replacement therapy.

23 Jul 2024

New strategy for mRNA nanocarriers using triphenyl phosphonium

Among the vastly different ways of tackling a disease, controlling the genetic expression of cells is undoubtedly one of the most powerful. Over the past few decades, scientists have come up with dozens of innovative strategies that involve using messenger RNA (mRNA) to 'force' cells to build specific proteins. These mRNA-based therapies have recently gained prominence as vaccines against infectious diseases like COVID-19. Additionally, they hold significant potential for treating cancer and genetic disorders.

23 Jul 2024

New drugs show promise in shrinking breast cancer brain metastases

Researchers from Drexel's College of Medicine have identified new drugs that show early success in shrinking breast cancer tumors that have metastasized in the brain.

18 Jul 2024

Study links circadian rhythm disruption to obesity and diabetes

Disruption of circadian rhythms and clock gene expression is linked to adverse metabolic health outcomes, including obesity and diabetes. Further research is needed to understand these relationships and their implications for treatment and prevention.

17 Jul 2024

Tufts researchers uncover immune cell link to doxorubicin-induced heart damage

There's still much to learn about how doxorubicin, a 50-year-old chemotherapy drug, causes its most concerning side effects.

17 Jul 2024

Mouse Model News and Research

Dopamine treatment can reduce Alzheimer's plaques and improve memory

New compound ZTA-26 could be a game-changer in lipid metabolism regulation

Breakthrough MS drug uses green mamba venom discovery to promote myelin repair

New dual-purpose contrast agent revolutionizes PET and MRI integration for enhanced diagnosis

Novel antibiotic compound shows promise against drug-resistant bacteria and flesh-eating infections

Study explores interplay between bone, adrenal glands, and aging

Study reveals serotonin's role in ependymoma tumor growth

Genetic loss of miR-205 boosts mammary gland development in mice, reveals new insights into breast cancer suppression

Cordyceps sinensis shown to alleviate idiopathic pulmonary fibrosis in mice

Researchers identify a potential therapeutic target for advanced multiple sclerosis

Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

Creating the first genetically susceptible mice for late-onset Alzheimer's

Oligodendrocytes identified as key source of amyloid beta in Alzheimer's disease

Epigenetic insights into stroke-induced immunological changes

Revolutionary ATP imaging technique sheds light on kidney cell energy production

New study sheds light on irregular heartbeat risk

New strategy for mRNA nanocarriers using triphenyl phosphonium

New drugs show promise in shrinking breast cancer brain metastases

Study links circadian rhythm disruption to obesity and diabetes

Tufts researchers uncover immune cell link to doxorubicin-induced heart damage

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