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A new trial investigates whether the MIND diet can be scaled for obesity management

This study protocol outlines a 12-week randomized trial testing whether a MIND diet intervention is feasible, acceptable, and sustainable for adults with obesity in Sweden. It will generate preliminary evidence on adherence, mental well-being, and gut microbiota changes to inform larger efficacy trials.

14 Dec 2025

Cryo-EM reveals NPFFR1 activation and guides novel ligand design

This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1 (NPFFR1)-a Gi/o-coupled receptor that responds to endogenous RF-amide peptides (RFRP-3 from pro-NPFFB, NPFF from pro-NPFFA) and regulates physiological processes like opioid function, pain, and energy homeostasis.

13 Dec 2025

External signals control oncolytic bacteria for precise cancer therapy delivery

Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune activation, and controllable therapeutic delivery. This review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy.

13 Dec 2025

UC Irvine receives funding for clinical trial of neural stem cell therapy for Huntington's disease

Leslie M. Thompson, Donald Bren Professor of psychiatry and human behavior as well as neurobiology and behavior at the University of California, Irvine, has received an $11,999,933 grant from the California Institute for Regenerative Medicine for an unprecedented clinical trial of a novel neural stem cell therapy for Huntington's disease.

12 Dec 2025

Novel nanomedicine mPEG@ELA-11 shows potential in treating atherosclerosis

A pioneering study led by researchers from Tongji University School of Medicine, Shanghai Jiao Tong University School of Medicine and Naval Medical University has unveiled a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis (AS), a leading cause of cardiovascular diseases globally.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Most clinical trials fail to reflect America’s racial and ethnic diversity

A new study finds just 6% of clinical trials used to approve new drugs in the U.S. reflect the country's racial and ethnic makeup, with an increasing trend of trials underrepresenting Black and Hispanic individuals.

12 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

How specific foods reshape oxidative stress responses during and after high-intensity training

Carbohydrate-rich foods blunt acute oxidative stress during fasted high-intensity exercise, while polyphenol-rich foods accelerate early recovery by reducing post-exercise ROS. Findings highlight how nutrient timing shapes redox responses in sedentary young women undergoing resistance-circuit HIIT.

11 Dec 2025

Study finds dramatic increase in ADHD medication use

Annual prescriptions for drugs to treat attention-deficit/hyperactivity disorder (ADHD) increased 157 percent in Ontario from 2015 to 2023, according to a new study from researchers at ICES, North York General, and The Hospital for Sick Children (SickKids).

11 Dec 2025

Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data

Cleveland Clinic researchers are presenting final Phase 1 data from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

11 Dec 2025

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Pancreatic cancer is one of the deadliest malignancies, with survival rates remaining dismally low despite major advances in oncology.

11 Dec 2025

Study finds sharp rise in prescriptions for stimulant medications used to treat ADHD

A new Ontario-based study has found a significant rise in prescriptions for stimulant medications used to treat attention-deficit/hyperactivity disorder (ADHD), particularly among adults and females.

11 Dec 2025

Wheelchair? Hearing aids? Yes. ‘Disabled?' No way.

In her house in Ypsilanti, Michigan, Barbara Meade said, "there are walkers and wheelchairs and oxygen and cannulas all over the place."

11 Dec 2025

Mathematical modeling identifies strategies to eliminate cervical cancer

Cervical cancer is the fourth most common cancer for women in the world, with more than 660,000 new cases and nearly 350,000 deaths per year.

10 Dec 2025

Why the form of vitamin B12 you take may matter more than your intake

This comprehensive review examines vitamin B12 absorption, physiological roles, deficiency states, and dietary sources, with particular attention to differences between natural and synthetic forms. The authors conclude that while all B12 forms raise circulating levels, methylcobalamin may offer advantages in specific clinical contexts, especially where absorption or metabolic conversion is impaired.

10 Dec 2025

Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative

Van Andel Institute and Cure Parkinson's have renewed a funding agreement to support the International Linked Clinical Trials Program, the world's largest drug repurposing clinical trial initiative for Parkinson's disease.

10 Dec 2025

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending time off chemotherapy, according to results from the phase III clinical trial HER2CLIMB-05 presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

$EpilepsyGTx raises $33 million Series A to develop single dose gene therapy for focal refractory epilepsy$

EpilepsyGTx raises $33 million Series A to develop single dose gene therapy for focal refractory epilepsy

EpilepsyGTx, a biotechnology company focused on research and development of cutting-edge gene therapies to treat refractory epilepsy, today announced it has raised $33 million in a Series A financing to advance its lead program EPY201 through Phase 1/2a clinical trials.

10 Dec 2025

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Efficacy News and Research

A new trial investigates whether the MIND diet can be scaled for obesity management

Cryo-EM reveals NPFFR1 activation and guides novel ligand design

External signals control oncolytic bacteria for precise cancer therapy delivery

UC Irvine receives funding for clinical trial of neural stem cell therapy for Huntington's disease

Novel nanomedicine mPEG@ELA-11 shows potential in treating atherosclerosis

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Most clinical trials fail to reflect America’s racial and ethnic diversity

Scientists outline how organ rejuvenation strategies could solve the donor shortage

How specific foods reshape oxidative stress responses during and after high-intensity training

Study finds dramatic increase in ADHD medication use

Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Study finds sharp rise in prescriptions for stimulant medications used to treat ADHD

Wheelchair? Hearing aids? Yes. ‘Disabled?' No way.

Mathematical modeling identifies strategies to eliminate cervical cancer

Why the form of vitamin B12 you take may matter more than your intake

Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Triaptosis could be a promising strategy in the fight against cancer

EpilepsyGTx raises $33 million Series A to develop single dose gene therapy for focal refractory epilepsy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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