Nanoparticle News and Research

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In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: in terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers.

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Microglia-targeting nanotherapeutics for treatment of neurodegenerative disorders

Inspired by the need for new and better therapies for neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, Rutgers University researchers are exploring the link between uncontrolled inflammation within the brain and the brain's immune cells, known as microglia.

8 Sep 2020

Therapeutic derived from turmeric shows promise in treating canine ocular condition

Researchers at Texas A&M University have produced a therapeutic derived from turmeric, a spice long-praised for its natural anti-inflammatory properties, that shows promise in decreasing ocular inflammation in dogs suffering from uveitis, an inflammation of the eye that leads to pain and reduced vision.

4 Sep 2020

Tattoo ink could be the key to improving cancer detection

The humble ink in a tattoo artist's needle could be the key to improving the detection of cancer, thanks to new research from the USC Viterbi Department of Biomedical Engineering.

2 Sep 2020

A global vaccine is sufficient to combat COVID-19 infection, indicates study

Genetic analysis of sequences from more than 27,000 individuals infected with the coronavirus that causes COVID-19 reveals that the virus has mutated minimally since December 2019, suggesting one vaccine would be sufficient to combat global infections.

2 Sep 2020

Spike ferritin nanoparticles show potential as SARS-CoV-2 vaccine

Now, a new study published on the preprint server bioRxiv* in August 2020 reports the induction of neutralizing antibodies in mice by a single dose of a ferritin nanoparticle-based vaccine containing the spike protein.

1 Sep 2020

Virginia Tech researcher wins NIH award to study possible treatments for metastatic breast cancer

Eli Vlaisavljevich, an assistant professor of biomedical engineering and mechanics at Virginia Tech, received a Trailblazer Award from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health to research possible treatments for metastatic breast cancer.

28 Aug 2020

Pfizer/BioNTech COVID-19 vaccine candidate BNT162b2 profiled for large scale clinical trials

Although two RNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates elicited similar, dose-dependent neutralizing antibody titers in both younger and older adults, a recent study by researchers from the U.S. and Germany has shown that BNT162b2 is associated with less systemic reactogenicity in elderly individuals – supporting its selection for further phase 2/3 clinical trials. The study is currently available on medRxiv* preprint server.

23 Aug 2020

AnteoTech's COVID-19 antigen and Flu A&B test detects SARS-Cov-2, influenza in less than 15 minutes

AnteoTech Ltd has successfully developed proof-of-concept COVID-19 antigen and Flu A&B point-of-care lateral flow tests that can detect the presence of SARS-Cov-2 and influenza in less than 15 minutes.

21 Aug 2020

New prototype device non-invasively detects COVID-19 in exhaled breath of infected patients

Few people who have undergone nasopharyngeal swabs for coronavirus testing would describe it as a pleasant experience.

20 Aug 2020

New type of immunotherapy extends survival of mice with triple negative breast tumors

Immunotherapies for cancer - treatments that prime the immune system to attack tumors - are valuable weapons in the anti-cancer arsenal. But some cancers are more difficult to target with this strategy than others.

17 Aug 2020

Nanoparticle carriers expand the effectiveness of gene therapies for human eye diseases

NIBIB-funded researchers have created nanoparticles for successful gene therapy of a mouse model of macular degeneration.

15 Aug 2020

De novo designed SARS-CoV-2 nanoparticle vaccine

In light of the continuing threat to public health, social functioning, and economic activity posed by the COVID-19 pandemic, scientists are working urgently to bring out a vaccine that is both safe and effective, and capable of mass production. A new paper published on the preprint server bioRxiv* in August 2020 shows that such a vaccine may be produced by using arrays of one severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein on a nanoparticle platform.

14 Aug 2020

Researchers discover dose threshold that improves delivery of cancer-fighting drugs into a tumor

University of Toronto Engineering researchers have discovered a dose threshold that greatly increases the delivery of cancer-fighting drugs into a tumor.

11 Aug 2020

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

A new study by researchers from the Scripps Research Institute and Novavax Inc. in the US affirms the structural integrity of the full-length SARS-CoV-2 spike glycoprotein immunogen. It enables the interpretation of immune responses to this multivalent nanoparticle immunogen. Their results are currently available on bioRxiv preprint server.

9 Aug 2020

Encouraging results from Phase I NovaVax SARS-CoV-2 nanoparticle vaccine trial

NVX-CoV2373, a recombinant nanoparticle vaccine developed by Novavax and manufactured at Emergent Biosolutions, was found to be well tolerated and immunogenic – inducing T-cell response and neutralization antibodies four-fold higher than the mean observed in hospitalized coronavirus disease (COVID-19) patients, shows a recent study available on the medRxiv* preprint server.

9 Aug 2020

Nanoparticle method captures and measures common marker of heart disease

Researchers at the University of Wisconsin-Madison have developed a method combining sticky nanoparticles with high-precision protein measurement to capture and analyze a common marker of heart disease to reveal details that were previously inaccessible.

7 Aug 2020

Nanoparticle News and Research

Further Reading

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Microglia-targeting nanotherapeutics for treatment of neurodegenerative disorders

Therapeutic derived from turmeric shows promise in treating canine ocular condition

Tattoo ink could be the key to improving cancer detection

A global vaccine is sufficient to combat COVID-19 infection, indicates study

Spike ferritin nanoparticles show potential as SARS-CoV-2 vaccine

Virginia Tech researcher wins NIH award to study possible treatments for metastatic breast cancer

Pfizer/BioNTech COVID-19 vaccine candidate BNT162b2 profiled for large scale clinical trials

AnteoTech's COVID-19 antigen and Flu A&B test detects SARS-Cov-2, influenza in less than 15 minutes

New prototype device non-invasively detects COVID-19 in exhaled breath of infected patients

New type of immunotherapy extends survival of mice with triple negative breast tumors

Nanoparticle carriers expand the effectiveness of gene therapies for human eye diseases

De novo designed SARS-CoV-2 nanoparticle vaccine

Researchers discover dose threshold that improves delivery of cancer-fighting drugs into a tumor

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

Encouraging results from Phase I NovaVax SARS-CoV-2 nanoparticle vaccine trial

Nanoparticle method captures and measures common marker of heart disease

An 'intelligent' strategy for real-time evaluation of photothermal therapy efficiency on tumors

New rapid coronavirus test to be rolled out across care homes

Maternal vaccination could protect infants against RSV illness

How to solve the hidden bottleneck in lipid nanoparticle development eBook

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