Clinical Trial News and Research

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New drug shows potential to prevent painful side effect of therapy

About 50,000 people in the U.S. are diagnosed annually with head, neck, nasal and oral cancers. Most are treated with radiation, and of those, 70-80 percent develop a painful and debilitating side effect called severe oral mucositis.

20 Aug 2018

BOOST-3 clinical trial aims to improve outcomes for severe TBI patients

An estimated 2.5 million Americans sustain a traumatic brain injury, or TBI, each year, according to the Centers for Disease Control and Prevention. Severe TBI contributes to 30 percent of all injury-related deaths, and many who survive are left permanently disabled.

20 Aug 2018

New trial to investigate whether weight loss before conception can make mom and baby healthier

A woman's overall health before conception can impact her pregnancy and the health of her fetus.

19 Aug 2018

New drug- free, nanotechnology-based method detects and treats oral plaque

When the good and bad bacteria in our mouth become imbalanced, the bad bacteria form a biofilm (aka plaque), which can cause cavities, and if left untreated over time, can lead to cardiovascular and other inflammatory diseases like diabetes and bacterial pneumonia.

17 Aug 2018

Study compares survival outcomes in rural and urban cancer patients enrolled in clinical trials

When enrolled in a cancer clinical trial, the differences in survival rates between rural and urban patients are significantly reduced, SWOG study results show.

17 Aug 2018

Less-invasive options are slowing disease progression in glaucoma patients

Judith Smith, now 71, was at a routine appointment several years ago with her longtime ophthalmologist when the doctor made a comment that her right eye looked a little suspicious for glaucoma, an incurable disease that occurs when the optic nerve is damaged by pressure building inside the eye.

17 Aug 2018

Ology Bioservices wins $8.4 million worth agreement to manufacture anti-Ebola monoclonal antibody

Ology Bioservices, Inc., a biologics contract development and manufacturing organization, announced today that it was awarded an Other Transaction Agreement to support the Joint Project Manager Medical Countermeasure Systems, a component of the Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense for advanced biologics manufacturing services—specifically, to manufacture an anti-Ebola monoclonal antibody.

17 Aug 2018

OHSU professor conducts clinical trial with artificial pancreas using Xeris' liquid glucagon

Xeris Pharmaceuticals, Inc., a specialty pharmaceutical company leveraging its novel technology platforms to develop and commercialize ready-to-use injectable and infusible drug formulations, announced today that Jessica Castle, M.D., an associate professor of medicine in the OHSU School of Medicine and OHSU Harold Schnitzer Diabetes Health Center in Portland, Oregon, is conducting a clinical trial with a dual-hormone artificial pancreas using Xeris' ready-to-use liquid glucagon to evaluate a new closed-loop algorithm.

17 Aug 2018

Seeking solutions to treat scleroderma

It begins with cold hands. Not just put-on-some-gloves cold. Instead, the fingers overreact to cold by turning white or blue and may become numb or tingly.

17 Aug 2018

Lowering pH inside tumor cells can slow down spread of cancer

A new study focusing on the environment inside cancer cells may lead to new targeted treatment strategies.

17 Aug 2018

Researchers describe promising strategy to remove melanoma's most powerful defenses

Immunotherapies use the immune system to fight cancer. But cancers like melanoma have found ways to turn off the immune system, allowing them to resist treatments and often leading to recurrence.

16 Aug 2018

NIH begins first-in-human trial of experimental live, attenuated Zika virus vaccine

Vaccinations have begun in a first-in-human trial of an experimental live, attenuated Zika virus vaccine developed by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

16 Aug 2018

Sun Pharma receives U.S. FDA approval for CEQUA to treat patients with dry eye disease

Sun Pharmaceutical Industries Ltd. today announced that Sun Pharma has received approval for CEQUA (cyclosporine ophthalmic solution) 0.09%, from the U.S. Food and Drug Administration. CEQUA is indicated to increase tear production in patients with keratoconjunctivitis sicca (dry eye).

16 Aug 2018

Trial shows PARP inhibitor as novel treatment option for patients with advanced breast cancers

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

16 Aug 2018

Tufts researchers win grant to study integration of genomic sequencing into neonatal care

Tufts Medical Center researchers have received a five-year grant award for more than $8 million from the National Center For Advancing Translational Sciences of the National Institutes of Health to study the integration of targeted genomic sequencing into neonatal diagnosis and care.

16 Aug 2018

Scientists explore ways for drug therapies to reach deadly brain tumors

The blood-brain barrier is a specialized network of vascular and brain cells that acts as the brain's security system, helping to safeguard the brain and regulate the flow of substances into and out of it.

15 Aug 2018

Clinical study suggests new treatment direction for head and neck cancer in heavy smokers

Patients with a greater than 10 pack/year history of smoking tend to develop an especially dangerous form of head and neck squamous cell cancer for which prognosis remains poor and treatments have changed little during the past two decades.

14 Aug 2018

Scientists identify mutational signatures in ovarian cancer

Scientists have identified distinct patterns of genetic mutation among patients with ovarian cancer that could help them personalise treatment in the future.

14 Aug 2018

American College of Rheumatology receives grants to support development of lupus clinical trials

The American College of Rheumatology today announced the receipt of two, two-year grants from the Office of Minority Health to support the development of programs that aim to increase the recruitment and enrollment in lupus clinical trials of minority populations affected by lupus.

14 Aug 2018

Experts provide insight into novel concepts and approaches for stroke rehabilitation

Stroke remains a leading cause of adult disability, and the global burden of stroke continues to grow with devastating consequences for patients, families, and caregivers.

14 Aug 2018

Clinical Trial News and Research

New drug shows potential to prevent painful side effect of therapy

BOOST-3 clinical trial aims to improve outcomes for severe TBI patients

New trial to investigate whether weight loss before conception can make mom and baby healthier

New drug- free, nanotechnology-based method detects and treats oral plaque

Study compares survival outcomes in rural and urban cancer patients enrolled in clinical trials

Less-invasive options are slowing disease progression in glaucoma patients

Ology Bioservices wins $8.4 million worth agreement to manufacture anti-Ebola monoclonal antibody

OHSU professor conducts clinical trial with artificial pancreas using Xeris' liquid glucagon

Seeking solutions to treat scleroderma

Lowering pH inside tumor cells can slow down spread of cancer

Researchers describe promising strategy to remove melanoma's most powerful defenses

NIH begins first-in-human trial of experimental live, attenuated Zika virus vaccine

Sun Pharma receives U.S. FDA approval for CEQUA to treat patients with dry eye disease

Trial shows PARP inhibitor as novel treatment option for patients with advanced breast cancers

Tufts researchers win grant to study integration of genomic sequencing into neonatal care

Scientists explore ways for drug therapies to reach deadly brain tumors

Clinical study suggests new treatment direction for head and neck cancer in heavy smokers

Scientists identify mutational signatures in ovarian cancer

American College of Rheumatology receives grants to support development of lupus clinical trials

Experts provide insight into novel concepts and approaches for stroke rehabilitation

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