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New tool uses artificial intelligence to calculate harmful effects of medicines

Research led by the University of Exeter and Kent and Medway NHS and Social Care Partnership Trust, published in Age and Ageing, assessed a new tool designed to calculate which medicines are more likely to experience adverse anticholinergic effects on the body and brain.

7 Sep 2022

Researchers develop universally accessible application that can simulate complex molecular interactions

A team led by University of Minnesota Twin Cities biomedical engineers has developed a universally accessible application that can simulate complex molecular interactions, which will allow researchers to design better treatments for diseases like cancer and COVID-19.

6 Sep 2022

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming.

6 Sep 2022

Metabolic signature could be a potential target for new breast cancer therapies

Despite advancements in cancer detection and treatment, breast cancer that comes back or spreads still presents a challenge to researchers and oncologists.

6 Sep 2022

Novel method can be used to study the resistance profile of bacteria that cause meningitis

A study published in the journal PLOS ONE could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis – an inflammation of the membranes that envelop the brain and spinal cord – are resistant to antibiotics.

6 Sep 2022

In the rush to curtail abortion, states adopt a jumbled stew of definitions for human life

As life-preserving medical technology advanced in the second half of the 20th century, doctors and families were faced with a thorny decision, one with weighty legal and moral implications: How should we define when life ends? Cardiopulmonary bypass machines could keep the blood pumping and ventilators could maintain breathing long after a patient's natural ability to perform those vital functions had ceased.

6 Sep 2022

What is currently known about the mechanism and treatments of long COVID?

The current understanding of the mechanisms underlying long COVID or post-acute sequelae of COVID and potential treatment methods that show promise in long COVID management.

6 Sep 2022

The existing molecular variance levels in haplotypes of the interferon-alpha-beta receptor gene in Orthopoxviruses

Researchers performed an analysis of molecular variance in 59 haplotypes of the IFNAR gene, departing from monkeypox virus, camelpox virus, buffalopox virus, ectromelia virus, cowpox virus, rabbitpox virus, variola virus, and vaccinia virus.

6 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

Neurological manifestations associated with monkeypox infection

A new study presents current information regarding the neurological presentations and complications of monkeypox infection.

5 Sep 2022

Inhaled glucocorticoids linked to changes in brain matter

A recent BMJ Open study conducted a cross-sectional analysis to test the hypothesis that the usage of systemic and inhaled glucocorticoids was associated with alterations in grey matter volume (GMV) and white matter microstructure.

5 Sep 2022

Monkeypox infection causing acute myocarditis - case report

A recent case report published in the journal JACC Case Reports indicated that monkeypox infection might be associated with acute myocarditis or heart muscle inflammation.

5 Sep 2022

Researchers use Viking poop to genetically map one of the oldest human parasites

Using stool samples from Viking latrines, researchers at the University of Copenhagen have genetically mapped one of the oldest human parasites – the whipworm.

5 Sep 2022

High-quality human clinical trials needed to determine the benefits of CBD for heart disease patients

As cannabidiol (CBD) use rises, high quality randomized clinical trials are needed to determine if anti-inflammatory benefits of CBD for heart disease seen in preclinical data will work in a real-world setting, according to research presented at ACC Latin America 2022 Together with CardioAcademic.

5 Sep 2022

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Announcing a new article publication from Acta Pharmaceutica Sinica B. The brain is the most advanced organ with various complex structural and functional microregions.

5 Sep 2022

Recent advances in nano-based therapeutic strategies for the treatment of infectious lung diseases

Announcing a new publication for Acta Materia Medica journal. Infectious lung diseases are inflammatory diseases of the lungs caused by infectious agents such as bacteria, viruses or fungi.

5 Sep 2022

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Synexa is an industry-leading biomarker and large molecule bio analytic research service provider. In this interview, NewsMedical speaks with Natalie Strickland, a principal scientist at Synexa, about alternative approaches to flow cytometry.

From Synexa Life Sciences 5 Sep 2022

Novel tool evaluates the contractile force-related state of myotubes

Researchers from Tokyo Metropolitan University have developed a way to characterize the force generated by contracting myotubes, precursors to skeletal muscle fiber, combining electrostimulation and analysis of wrinkles in the silicone substrate on which they are mounted. Existing methods rely on muscle mass or the expression of certain proteins, both not as strongly correlated with muscle strength. Accurate measurement of myotube strength promises more effective screening of drug targets for treating muscle atrophy.

5 Sep 2022

Male hypogonadism associated with risk of hospitalization for COVID-19

Men with low testosterone levels are more likely to require hospitalization after COVID-19 infection than men with normal levels or those on testosterone therapy, according to Saint Louis University School of Medicine and Washington University School of Medicine in St. Louis researchers.

2 Sep 2022

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment.

2 Sep 2022

Drugs News and Research

New tool uses artificial intelligence to calculate harmful effects of medicines

Researchers develop universally accessible application that can simulate complex molecular interactions

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

Metabolic signature could be a potential target for new breast cancer therapies

Novel method can be used to study the resistance profile of bacteria that cause meningitis

In the rush to curtail abortion, states adopt a jumbled stew of definitions for human life

What is currently known about the mechanism and treatments of long COVID?

The existing molecular variance levels in haplotypes of the interferon-alpha-beta receptor gene in Orthopoxviruses

Auranofin inhibits SARS-CoV-2 replication

Neurological manifestations associated with monkeypox infection

Inhaled glucocorticoids linked to changes in brain matter

Monkeypox infection causing acute myocarditis - case report

Researchers use Viking poop to genetically map one of the oldest human parasites

High-quality human clinical trials needed to determine the benefits of CBD for heart disease patients

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Recent advances in nano-based therapeutic strategies for the treatment of infectious lung diseases

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Novel tool evaluates the contractile force-related state of myotubes

Male hypogonadism associated with risk of hospitalization for COVID-19

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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