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Antioxidant-enzyme interactions and their role in non-communicable diseases

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs).

21 Feb 2025

Zinc-carrying proteins may activate PPIs in the absence of gastric acid

Acid reducing medicines from the group of proton pump inhibitors (PPIs) are best-selling drugs that prevent and alleviate stomach problems.

21 Feb 2025

Exploring how 25-hydroxycholesterol triggers ferroptosis in glial cells

Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis.

20 Feb 2025

Unfolded protein response disruptions contribute to colorectal cancer and gut-related disorders

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

20 Feb 2025

Do prenatal antibiotics weaken breast milk immunity? A new study aims to find out

A new study will investigate whether prenatal antibiotic use impairs breast milk immune function and disrupts neonatal gut microbiota, potentially affecting infant health. Researchers aim to assess how prolonged antibiotic exposure in late pregnancy alters breast milk IgA and neonatal immune development.

19 Feb 2025

Vitamin E significantly improves liver health in MASH patients, new study finds

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

19 Feb 2025

Novel classification system for SJS/TEN aims to improve patient care

First identified by Stevens and Johnson in 1922, SJS and TEN are now recognized as disorders with a continuum of severity, from milder forms (SJS) to the most severe (TEN).

19 Feb 2025

Cancer cells cooperate to source nutrients and support tumor growth

Cancer cells work together to source nutrients from their environment-a cooperative process that was previously overlooked by scientists but may be a promising target for treating cancer.

19 Feb 2025

Genetic mutation linked to schizophrenia in both humans and mice

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University of Illinois Urbana-Champaign and colleagues in Massachusetts and Germany.

19 Feb 2025

Neuroestrogens likely contribute to appetite regulation

Although a woman's ovaries produce the most estrogen, various types of estrogen are also synthesized throughout different tissues in the body, including the brain's neurons.

19 Feb 2025

Cholesterol metabolite linked to Parkinson's disease development in mice

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson's disease in mice.

18 Feb 2025

Study links sucrase defects to increased IBS risk and severe symptoms

Sucrase-isomaltase (SI) is an intestinal enzyme critical for the digestion of dietary carbohydrates, particularly sucrose and starch.

17 Feb 2025

New gene switch may lead to precise treatments for metabolic diseases

ETH researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin.

17 Feb 2025

Dead bacteria offer nutrients to neighbors through evolved enzyme

Darwin's theory of natural selection provides an explanation for why organisms develop traits that help them survive and reproduce.

14 Feb 2025

New biomarker can accurately predict outcomes in meningiomas and breast cancers

Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers.

13 Feb 2025