Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung function in patients with idiopathic pulmonary fibrosis in a 12-week phase 2a clinical trial. The highest dose group demonstrated a trend toward increased forced vital capacity, especially among patients not receiving standard antifibrotic therapy, supporting further clinical investigation.

4 Jun 2025

Variability in blood sugar response depends on individual's metabolic health status

A study led by researchers at Stanford Medicine shows that differences in blood sugar responses to certain carbohydrates depend on details of an individual's metabolic health status.

4 Jun 2025

Key proteins and pathways drive the success of CAR-T cell therapy

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways involved in the efficacy of immunotherapy based on CAR-T cells (lymphocytes modified in the laboratory to fight cancer).

4 Jun 2025

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

A randomized clinical trial found that low-dose lithium aspartate did not improve cognitive dysfunction or fatigue in long COVID patients. Higher doses showed possible benefits in a small exploratory substudy, but larger trials are needed.

4 Jun 2025

Early camizestrant therapy keeps advanced breast cancer in check

Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced breast cancer. The proactive, biomarker-guided approach allows earlier intervention and may redefine standard care.

3 Jun 2025

Phytosterols in plant-based foods linked to lower risk of heart disease and type 2 diabetes

Heart disease and type 2 diabetes rank among the leading causes of death and disability in the United States, and eating a healthy diet rich in plant-based foods can help to prevent or delay both of these conditions.

3 Jun 2025

High-fiber plant-based diet could benefit patients at risk for developing multiple myeloma

Results from a new clinical trial suggest that a high-fiber plant-based diet could benefit patients at risk for developing multiple myeloma, the second most common type of blood cancer.

2 Jun 2025

Linoleic acid may help to lower risks for heart disease and type 2 diabetes

New research that used blood markers to measure linoleic acid levels and their relation to cardiometabolic risk adds evidence that this omega-6 fatty acid may help to lower risks for heart disease and type 2 diabetes.

1 Jun 2025

New trial offers hope for men with aggressive prostate cancer

Many men with aggressive prostate cancer can experience a high rate of recurrence despite treatment.

30 May 2025

New AI test identifies prostate cancer patients who benefit from abiraterone

A new artificial intelligence (AI) test can identify which men with prostate cancer will benefit most from the life-extending drug abiraterone, in clinical trial results presented by scientists from UCL and the Institute of Cancer Research.

30 May 2025

LUCAS technology revolutionizes rapid viral diagnostics

Mass General Brigham researchers are shining a powerful new light into the viral darkness with the development of Luminescence CAscade-based Sensor (LUCAS), a rapid, portable, highly-sensitive diagnostic tool for processing complex biological samples.

30 May 2025

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have identified a new biomarker, TTF-1, that was predictive of survival outcomes for patients with advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC), following treatment with the KRAS targeted therapy sotorasib.

30 May 2025

Study identifies C5aR1 as a key marker of metastasis in skin cancer

Researchers have identified C5aR1 as a novel biomarker for metastasis risk and poor prognosis in patients with cutaneous squamous cell carcinoma (cSCC), the most common type of metastatic skin cancer.

29 May 2025

Coronary inflammation marker helps identify hidden heart risk in young adults

Researchers found that peri-coronary adipose tissue attenuation (PCAT), a marker of coronary inflammation, is independently associated with coronary artery disease (CAD) in young adults. Adding PCAT to standard risk models improved detection of early atherosclerosis, even in patients with a zero calcium score.

28 May 2025

Alcohol abuse drug may mitigate trauma-induced damage, especially in females

Runaway cell death and inflammation triggered by severe trauma may be interrupted by a drug used to prevent alcohol abuse – and it may be particularly effective in females, according to new research led by University of Pittsburgh School of Medicine surgeon-scientists and published today in Science Translational Medicine.

28 May 2025

Alzheimer’s blood biomarkers predict faster muscle strength loss in older adults

A large Swedish cohort study found that elevated blood biomarkers associated with Alzheimer’s disease—including p-tau217, p-tau181, neurofilament light chain, and GFAP—predict accelerated muscle strength decline over 12 years in dementia-free older adults. These findings suggest that early identification of Alzheimer’s-related biomarkers could help clinicians intervene sooner to prevent sarcopenia and related adverse outcomes in aging populations.

27 May 2025

University of Houston receives $3 million to set up a Cancer Immunotherapy Biomarker Core

As part of a $93 million grant package, the Cancer Prevention and Research Institute of Texas, known for funding groundbreaking projects, has awarded the University of Houston $3 million to set up a Cancer Immunotherapy Biomarker Core.

27 May 2025

New biomarker identified for predicting microvascular health of the kidneys

In a world first, Canadian scientists at the CRCHUM, the hospital research centre affiliated with Université de Montréal, have identified microRNA able to protect small blood vessels and support kidney function after severe injury.

27 May 2025

Integrating pharmacogenomics into everyday clinical practice can transform patient care

Pharmacogenomics studies how individuals respond to drugs based on their genetic code. Using that knowledge to guide prescribing in routine care could lead to better outcomes for patients and save money for health systems.

26 May 2025

Heavy smoking triggers systemic inflammation and vascular damage in new biomarker study

Heavy smoking in adult males significantly increases oxidative stress, inflammation, and vascular dysfunction, as shown by comprehensive blood and tissue biomarker analysis. The findings highlight measurable biological damage and reinforce the urgent need for targeted public health interventions.

26 May 2025

Biomarker News and Research

Further Reading

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

Variability in blood sugar response depends on individual's metabolic health status

Key proteins and pathways drive the success of CAR-T cell therapy

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

Early camizestrant therapy keeps advanced breast cancer in check

Phytosterols in plant-based foods linked to lower risk of heart disease and type 2 diabetes

High-fiber plant-based diet could benefit patients at risk for developing multiple myeloma

Linoleic acid may help to lower risks for heart disease and type 2 diabetes

New trial offers hope for men with aggressive prostate cancer

New AI test identifies prostate cancer patients who benefit from abiraterone

LUCAS technology revolutionizes rapid viral diagnostics

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

Study identifies C5aR1 as a key marker of metastasis in skin cancer

Coronary inflammation marker helps identify hidden heart risk in young adults

Alcohol abuse drug may mitigate trauma-induced damage, especially in females

Alzheimer’s blood biomarkers predict faster muscle strength loss in older adults

University of Houston receives $3 million to set up a Cancer Immunotherapy Biomarker Core

New biomarker identified for predicting microvascular health of the kidneys

Integrating pharmacogenomics into everyday clinical practice can transform patient care

Heavy smoking triggers systemic inflammation and vascular damage in new biomarker study

Event guide: 16th Clinical Biomarkers & CDx Summit Europe eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo