Immune System News and Research

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Australian researchers pinpoint specific genetic changes linked to severe AMD

Australian researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD).

9 Dec 2025

Patients receiving T-cell redirecting therapies can safely be monitored at home

Patients who receive T-cell redirecting therapies are typically hospitalized for several days after treatment to watch for side effects.

9 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Early-life RSV infection and parental allergy interact to substantially increase childhood asthma risk, supported by population data from more than 1.5 million children and mechanistic mouse experiments. The study shows that viral infection reprograms neonatal immune responses by altering how maternally transferred allergen-specific antibodies are handled, driving long-term allergic airway disease.

8 Dec 2025

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).

8 Dec 2025

Combination therapy may boost survival for people with aggressive lymphoma

A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma.

8 Dec 2025

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

A study funded in part by the National Institutes of Health (NIH) has revealed important insights into the genetics of deposits in the eye, known as reticular pseudodrusen (RPD), that are linked to greater risk of vision loss among people with age-related macular degeneration (AMD).

8 Dec 2025

Insufficient sleep may decrease life expectancy

A good night's sleep is more than a luxury: New research from Oregon Health & Science University suggests that insufficient sleep may shorten your life.

8 Dec 2025

Targeted approach of immunotherapy improves sepsis outcomes

Immunotherapy for sepsis is effective when doctors tailor the treatment precisely to the patient's immune system condition.

8 Dec 2025

Researchers discover a surprising ally in the fight against insulin resistance and type 2 diabetes

An international research team led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS together with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart Institute) has uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine (TMA).

8 Dec 2025

New trial shows major survival gains with epcoritamab added to standard R2 therapy

In a new trial, patients with follicular lymphoma had a significantly higher response to treatment and a nearly 80% reduction in the risk of death or disease progression if they received epcoritamab in addition to the standard second-line regimen versus the standard regimen alone.

7 Dec 2025

Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common present-day chemicals could explain why some women are more likely to develop endometriosis.

5 Dec 2025

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

5 Dec 2025

Engineered herpes virus activates potent immune responses against glioblastoma

Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells.

4 Dec 2025

Study uncovers strategy to sensitize estrogen receptor–positive breast tumors to immunotherapy

A study led by researchers at the Hospital del Mar Research Institute advances one of the most significant milestones in breast cancer treatment, making immunotherapy effective against the most common tumor type, estrogen receptor-positive or luminal breast cancer.

4 Dec 2025

Organ-on-a-chip system reveals how aging weakens vaccine-driven anti-cancer immunity

Dr. Vadim Jucaud's lab at the Terasaki Institute has introduced a new organ-on-a-chip platform that recapitulates age-dependent immune responses, offering a more accurate testing bed for evaluating cancer vaccine performance in older adults, the population most affected by cancer and often overlooked in traditional preclinical testing.

4 Dec 2025

New drug combination shows promise for overcoming resistance in ovarian cancer

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Immune System News and Research

Australian researchers pinpoint specific genetic changes linked to severe AMD

Patients receiving T-cell redirecting therapies can safely be monitored at home

Online reference library provides a more accurate picture of drug exposure

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

Combination therapy may boost survival for people with aggressive lymphoma

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

Insufficient sleep may decrease life expectancy

Targeted approach of immunotherapy improves sepsis outcomes

Researchers discover a surprising ally in the fight against insulin resistance and type 2 diabetes

New trial shows major survival gains with epcoritamab added to standard R2 therapy

Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Engineered herpes virus activates potent immune responses against glioblastoma

Study uncovers strategy to sensitize estrogen receptor–positive breast tumors to immunotherapy

Organ-on-a-chip system reveals how aging weakens vaccine-driven anti-cancer immunity

New drug combination shows promise for overcoming resistance in ovarian cancer

Common childhood virus linked to bladder cancer later in life

Injectable scaffold vaccine shows strong protection against implant-related MRSA

New rapid test distinguishes real HIV infections from vaccine-related false positives

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