Metabolic Disorders News and Research

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Seattle Children’s opens first clinical trial to study IBD and GVHD in pediatric patients

In an effort to find new strategies to personalize treatment for pediatric patients, Seattle Children's has opened the first clinical trial applying next-generation T-cell receptor sequencing and single-cell gene expression analysis to better understand how the immune system drives both inflammatory bowel disease in pediatric autoimmunity patients and graft-versus host disease in pediatric bone marrow transplant patients.

From 10x Genomics, Inc. 23 May 2017

Dry blood samples could save resources, benefit early diagnostics and treatment

A drop of blood on filter paper, allowed to dry and stored for future diagnostic purposes - considerably easier than the present-day, resource-consuming method using frozen blood samples in plastic tubes.

22 May 2017

New research could be first step toward drug to treat Zika infections

New research led by Alexey Terskikh, Ph.D., associate professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), and Alex Strongin, Ph.D., professor at SBP, could be a first step toward a drug to treat Zika infections. Publishing in Antiviral Research, the scientific team discovered a compound that prevents the virus from spreading.

16 May 2017

Breast cancer drug offers protection against obesity-related metabolic disorders

Tamoxifen, a selective estrogen receptor modulator, is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer.

11 May 2017

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced an exclusive, global collaboration and license agreement for the development and commercialization of gene therapy programs for Hemophilia A, including SB-525, one of Sangamo's four lead product candidates, which Sangamo expects will enter the clinic this quarter.

11 May 2017

Research findings reveal new approach to prevent age-related obesity

The function and distribution of adipose tissue in the body change during the course of life. Beige fat cells, a special type of adipocytes, have the capability to use energy reserves - fatty deposits - by generating heat in a process known as thermogenesis.

4 May 2017

New research uncovers role of mysterious molecule in skin cancer

New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona uncovers the modus operandi of a mysterious molecule called SPRIGHTLY that has been previously implicated in colorectal cancer, breast cancer, and melanoma.

3 May 2017

Study provides new insights on molecular mechanisms that impair muscle stem cells during aging

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a previously unrecognized step in stem cell-mediated muscle regeneration.

26 Apr 2017

MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

With the help of genetically engineered mice, scientists at the Massachusetts General Hospital are moving closer to establishing the role that increased intestinal permeability, sometimes called a "leaky gut," plays in chronic inflammatory conditions.

20 Apr 2017

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) ("good" fat) by employing two receptors on BAT cells as potential therapeutic targets.

17 Apr 2017

New initiative aims to study relationship between brain and obesity

The Naomi Berrie Diabetes Center at Columbia University Medical Center has launched an initiative to study the relationship between the brain and metabolic disorders such as obesity and diabetes.

5 Apr 2017

Low normalized grip strength linked to cardiometabolic diseases and disabilities in adults

A simple test to determine a person's grip strength may be a predictor of developing metabolic disorders in middle or older age, a new cross-continental study has found.

5 Apr 2017

Switching off glucocorticoid signaling in bone could protect against diet-induced metabolic disturbances

A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance, a new study conducted in mice finds.

4 Apr 2017

Patent analysis reveals that saffron bioactives can be used to treat multiple disorders

Increased stress levels, sleep disorders and obesity have become hallmarks of present lifestyle. These conditions are often correlated with serious health problems such as cancer, diabetes, cerebral ischemia, stroke, etc.

27 Mar 2017

Circadian misalignments may favor diabetes development

Like almost all light-sensitive living beings, human beings follow biological rhythms set on a period of about 24 hours.

20 Mar 2017

Why don’t patients always discuss hyperglycemia with their doctor?

Hyperglycemia occurs when a patient has higher than normal blood sugar levels. If the levels are very high, consistently 13-14 or above, the patient will start to feel tired, thirsty and feel the urge to go to the toilet frequently to pass urine (micturition).

17 Mar 2017

Metabolic Disorders News and Research

Seattle Children’s opens first clinical trial to study IBD and GVHD in pediatric patients

Dry blood samples could save resources, benefit early diagnostics and treatment

New research could be first step toward drug to treat Zika infections

Breast cancer drug offers protection against obesity-related metabolic disorders

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Research findings reveal new approach to prevent age-related obesity

New research uncovers role of mysterious molecule in skin cancer

Study provides new insights on molecular mechanisms that impair muscle stem cells during aging

MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

New initiative aims to study relationship between brain and obesity

Low normalized grip strength linked to cardiometabolic diseases and disabilities in adults

Switching off glucocorticoid signaling in bone could protect against diet-induced metabolic disturbances

Patent analysis reveals that saffron bioactives can be used to treat multiple disorders

Circadian misalignments may favor diabetes development

Why don’t patients always discuss hyperglycemia with their doctor?

Hormone secreted by bone cells can suppress appetite, mice study reveals

Researchers develop new tool that quickly reveals metabolic fluxes in cells

Upstate opens new public cord blood bank in New York

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

eBook: Integrated solutions for metabolic disease drug development eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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