Efficacy News and Research

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Collaborative effort advances next-generation therapies for pancreatic and GI cancers

Last year, researchers at the University of California, Riverside, developed a novel "molecular crowbar" strategy to degrade the oncogenic enzyme Pin1, a protein that is overexpressed in many tumors including pancreatic cancer.

12 Nov 2025

Hard water drives a surge in microplastic shedding from polyester, study finds

Researchers found that hand-washing in mineral-rich water dramatically increases microplastic fibre shedding from polyester fabrics, fragmenting fibres into shorter pieces. A two-layer PDMS coating sharply reduced shedding from green polyester but was far less effective on black polyester due to pre-existing surface finishes.

12 Nov 2025

Stanford scientists discover unexpected cancer resistance in aged mice

Old laboratory mice develop substantially fewer and less-aggressive lung tumors than younger animals in a new study led by Stanford University researchers.

12 Nov 2025

New typhoid conjugate vaccine shows safety and strong immune response in Africa

PATH and EuBiologics Co., LTD are pleased to announce Phase 3 results from a clinical trial of a typhoid conjugate vaccine (TCV), EuTYPH-C Inj.® Multi-dose. EuTYPH-C Inj.®

12 Nov 2025

Reimagining healthcare education for a sustainable NHS future

A fundamental rethink of how the NHS trains its future workforce is urgently needed, according to a new paper from the Higher Education Policy Institute (www.hepi.ac.uk), Rethinking Placement: Increasing Clinical Placement Efficacy for a Sustainable NHS Future (HEPI Report 194).

12 Nov 2025

How parental stress and long work weeks shape children’s reading outcomes

Parents working long hours provide less homework help, and this reduced support is linked with weaker reading comprehension in children. The study reveals that parental stress exacerbates this pattern, rendering demanding work schedules even more detrimental to learning.

12 Nov 2025

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Breakthroughs in theranostic nanomaterials for traumatic brain injury management

Traumatic brain injury (TBI) remains one of the most pressing public health challenges, leaving millions with lasting disabilities each year.

12 Nov 2025

Evolocumab shows clear benefit in preventing first-time heart attacks and strokes

Adding the PCSK9 inhibitor evolocumab to standard lipid-lowering therapy significantly reduced first major cardiovascular events in adults with atherosclerosis or high-risk diabetes who had never had a heart attack or stroke. The 4.6-year study confirmed durable safety and benefit, supporting earlier, more intensive LDL cholesterol control.

11 Nov 2025

New discovery reveals crucial link between cholesterol and breast cancer progression

Cancer Center at Illinois (CCIL) Program Leader Erik Nelson's lab made an important discovery about the relationship between cholesterol and breast cancer progression with crucial implications for breast cancer therapeutics.

11 Nov 2025

Innovative control strategy enhances stroke rehabilitation with CASIA-EXO exoskeleton

Stroke is one of the leading causes of non-traumatic disability worldwide, affecting more than 15 million people each year, with about three-quarters experiencing long-term functional impairments.

11 Nov 2025

Novel triple receptor agonist shows potent efficacy in lowering high triglycerides

In a small, short duration trial (12 weeks), a new medication called DR10624 reduced triglyceride levels in most patients with severe hypertriglyceridemia by more than 60%, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

11 Nov 2025

Comparative study finds higher rates of adverse events with ticagrelor

One year of treatment with either of two strong blood-thinning medications—ticagrelor and prasugrel—by people with type 1 or type 2 diabetes who had a drug-eluting stent placed in their heart to treat coronary artery blockages did not offer the same level of benefit to prevent stent clotting, heart attacks, and bleeding complications, according to findings presented during a preliminary late-breaking science session during the American Heart Association's Scientific Sessions 2025 in New Orleans on November 10.

10 Nov 2025

Green-synthesized nanoparticles enhance cidofovir's anticancer efficacy

In this study, led by Nahid Shahabadi from Razi University in Kermanshah, researchers developed an environmentally friendly approach to enhance the performance of cidofovir, a drug used to treat infections caused by DNA viruses. The work responds to the growing need for therapies that are safer, more effective, and better targeted.

10 Nov 2025

Prasugrel shows advantage over ticagrelor in diabetic patients after stent placement

One year of dual antiplatelet therapy with one of two potent P2Y12 inhibitors-ticagrelor or prasugrel-in people with Type 1 or Type 2 diabetes who had received a drug-eluting stent did not offer the same level of benefit at preventing stent clotting, heart attacks and bleeding complications, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

GLP-1 drugs beat metformin for weight control in teens with type 2 diabetes

In youth newly diagnosed with type 2 diabetes, GLP-1–based therapies, including semaglutide and tirzepatide, achieved similar blood sugar control but significantly greater reductions in body mass index than metformin. These findings highlight the potential of high-potency GLP-1 agents as effective monotherapy options in managing obesity and glycemic control in adolescents.

10 Nov 2025

Listening to slow-tempo music may boost sleep quality for people over 50

Music therapy significantly improves sleep quality in adults aged 50 and above, showing a moderate-to-large effect compared with control conditions. However, high heterogeneity and methodological weaknesses mean the evidence remains of very low certainty and requires confirmation in larger, standardized trials.

10 Nov 2025

One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and triglycerides in people with difficult-to-treat lipid disorders, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Daily oral medication matches injectable therapies in reducing bad cholesterol

Among people with a previous heart attack or stroke, or who are at high risk for one, a daily oral medication may offer an effective alternative to injections of PCSK9 inhibitors to lower low-density lipoprotein (LDL or "bad" cholesterol), according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Do dietary supplements really improve muscle health in non-athletes?

Dietary supplements can support muscle health, but their effectiveness varies. This review explores their role in physical activity and age-related muscle loss.

10 Nov 2025

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Efficacy News and Research

Collaborative effort advances next-generation therapies for pancreatic and GI cancers

Hard water drives a surge in microplastic shedding from polyester, study finds

Stanford scientists discover unexpected cancer resistance in aged mice

New typhoid conjugate vaccine shows safety and strong immune response in Africa

Reimagining healthcare education for a sustainable NHS future

How parental stress and long work weeks shape children’s reading outcomes

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Breakthroughs in theranostic nanomaterials for traumatic brain injury management

Evolocumab shows clear benefit in preventing first-time heart attacks and strokes

New discovery reveals crucial link between cholesterol and breast cancer progression

Innovative control strategy enhances stroke rehabilitation with CASIA-EXO exoskeleton

Novel triple receptor agonist shows potent efficacy in lowering high triglycerides

Comparative study finds higher rates of adverse events with ticagrelor

Green-synthesized nanoparticles enhance cidofovir's anticancer efficacy

Prasugrel shows advantage over ticagrelor in diabetic patients after stent placement

GLP-1 drugs beat metformin for weight control in teens with type 2 diabetes

Listening to slow-tempo music may boost sleep quality for people over 50

One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

Daily oral medication matches injectable therapies in reducing bad cholesterol

Do dietary supplements really improve muscle health in non-athletes?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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