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CDC researchers analyze the earliest batch of COVID-19 tests

The earliest batch of COVID-19 tests distributed by the US Centers for Disease Control and Prevention (CDC) exhibited false positive reactivity of negative controls due to flaws in assay design and contamination in one of the assay components, according to a CDC internal investigation published this week in the open-access journal PLOS ONE.

15 Dec 2021

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

A recent study recently demonstrates the endosomal transport of nanoparticle-based formulations for the effective delivery of mRNA-based therapeutics.

14 Dec 2021

Flawed genetic switches could be at the origin of malformations or developmental diseases

Embryonic development follows delicate stages: for everything to go well, many genes must coordinate their activity according to a very meticulous scheme and tempo. This precision mechanism sometimes fails, leading to more or less disabling malformations.

14 Dec 2021

CRISPR-Cas enzyme-based diagnostics to detect SARS-CoV-2 infection

A recent review in the journal Life provided a detailed description of CRISPR-Cas-based diagnostic techniques to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but also emphasized the potential use of this technology towards developing effective molecular diagnostic platforms for any future pandemic.

13 Dec 2021

Evaluating the virucidal activity of blue LED light against SARS-CoV-2 infection

A new study provides some possible explanations to the mechanisms by which antiviral activity is exerted by blue LED light and indicated that the alteration of the SARS-CoV-2 spike protein requires the presence of photosensitizers.

13 Dec 2021

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Researchers from the Biological Defence Programme of Singapore have investigated six of these antibodies.

13 Dec 2021

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

In a recent study, ten human PDZ-containing proteins showed significant interactions with the SARS-CoV-2 E protein in a PBM-dependent manner.

12 Dec 2021

Researchers uncover the journey of microglia in developing zebrafish

Microglia, the immune cells of the brain, form the first line of defense against neurodegenerative diseases and traumatic brain injuries.

8 Dec 2021

Cas12a-based bio-sensor for detecting SARS-CoV-2 mutations

Scientists develop an improved biosensor with Cas12a-based CRISPR on-site rapid detection system and discuss its ability to detect SARS-CoV-2 VOCs.

7 Dec 2021

Hypercoagulability of the blood responsible for cardiac thrombosis in COVID-19 patients

Researchers examined autopsy tissue samples of hearts from patients who died early in the COVID-19 pandemic.

7 Dec 2021

Metrion Biosciences expands ion channel drug discovery service capabilities and in-house expertise

Metrion today announced it has expanded its capabilities and expertise through the addition of automated low volume liquid handling capability.

From Metrion Biosciences Limited 7 Dec 2021

Announcing the Winners of The Scientist’s Top 10 Innovations of 2021

Each year The Scientist seeks to highlight the latest and greatest tools, technologies, and techniques to hit the life science landscape.

From Resolve Biosciences 6 Dec 2021

Researchers develop novel system for rapid and non-invasive detection of skin cholesterol

Cardiovascular diseases (CVDs) are the leading cause of death globally. Monitoring of lipid in patients with coronary heart disease (CHD) is important for decreasing the incidence of cardiovascular events.

29 Nov 2021

Using metal nanoparticles to fight SARS-CoV-2

A recent review article looks at the potential of nanotechnology in fighting severe acute respiratory syndrome 2 (SARS-CoV-2), with several possibilities of strategies in therapeutics, vaccines, and prevention.

25 Nov 2021

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

Scientists have hypothesized that the number of immune cells and the amount of cytokines produced in response to SARS-CoV-2 infection in pregnant women change in accordance with the timing of maternal infection in pregnancy. This study is available on the bioRxiv* preprint server.

24 Nov 2021

Fluorescence News and Research

CDC researchers analyze the earliest batch of COVID-19 tests

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

Flawed genetic switches could be at the origin of malformations or developmental diseases

CRISPR-Cas enzyme-based diagnostics to detect SARS-CoV-2 infection

Evaluating the virucidal activity of blue LED light against SARS-CoV-2 infection

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

Researchers uncover the journey of microglia in developing zebrafish

Cas12a-based bio-sensor for detecting SARS-CoV-2 mutations

Hypercoagulability of the blood responsible for cardiac thrombosis in COVID-19 patients

Metrion Biosciences expands ion channel drug discovery service capabilities and in-house expertise

Announcing the Winners of The Scientist’s Top 10 Innovations of 2021

Researchers develop novel system for rapid and non-invasive detection of skin cholesterol

Using metal nanoparticles to fight SARS-CoV-2

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

Novel method enables deeper analysis of endocrine disrupting chemicals' impact on gene expression

New "image analysis pipeline" provides insight into how disease changes the body

SARS-CoV-2 moves between permissive cells and non-permissive neuronal cells via tunneling nanotubes (TNT)

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

IFITM proteins are important replication cofactors for SARS-CoV-2, including Delta variant

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Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo