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Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Patients with non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitor sotorasib (Lumakras) had a two-year overall survival rate of 32.5 percent, according to data from the CodeBreaK 100 clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) finds that the consumption of healthy plant-based foods, including fruits, vegetables, nuts, coffee, and legumes, is associated with a lower risk of developing type 2 diabetes (T2D) in generally healthy people and support their role in diabetes prevention.

10 Apr 2022

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

Patients with advanced melanoma whose cancer does not respond to treatment with widely used immunotherapy drugs known as PD-1 inhibitors are often switched to treatment with a second type of immunotherapy drug – a CTLA-4 inhibitor such as the drug ipilimumab.

8 Apr 2022

Artificial intelligence model could predict side effects resulting from new combination therapies

Preliminary data from an artificial intelligence model could potentially predict side effects resulting from new combination therapies, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

8 Apr 2022

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

On Thursday, April 7, the Centers for Medicare and Medicaid (CMS) formalized its plan to cover the anti-amyloid drug Aduhelm only for patients enrolled in clinical trials.

8 Apr 2022

Researchers discover new mechanisms for bone loss in gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone.

8 Apr 2022

Expanding statin prescription could be a cost-effective intervention against cardiovascular disease

Expanding prescription of statin medication to reduce low-density lipoprotein cholesterol could be a cost-effective intervention against cardiovascular disease, according to a Northwestern Medicine study published in the journal Circulation.

8 Apr 2022

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

New findings from the ongoing Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study suggest that certain rheumatoid arthritis drugs may lower incidence of Alzheimer's disease and related dementias in people with cardiovascular disease.

8 Apr 2022

Nanomedicine for treating life-threatening brain tumors

Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka) has announced that Dr. Sabina Quader et al. published a review article focusing on the recent nanomedicines for brain cancers on Advanced Drug Delivery Review in this March.

8 Apr 2022

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Despite guidelines that call for early and aggressive treatment of rheumatoid arthritis, a new study suggests many older adults are not prescribed disease-modifying medications for their inflammatory autoimmune disease.

8 Apr 2022

Yale researchers discover immune response pathway that leads to severe COVID-19

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

7 Apr 2022

Unique immune cell fingerprint can help rapidly identify better treatment for autoimmune disease

Most autoimmune diseases are easy to diagnose but hard to treat. A paper published today in Science proposes using your unique immune cell fingerprint to rapidly identify which treatments will work for your autoimmune disease.

7 Apr 2022

Nobel-prize-winning breakthrough: Discovery of ion-channel sensors for temperature and pressure

For centuries, understanding the basis for how we detect, process and react to light, sound, temperature, pressure and other environmental signals has been a scientific focus.

7 Apr 2022

Smoking cessation could help heart disease patients gain five years of healthy life

Smoking cessation adds the same number of heart disease-free years to life as three preventive medications combined, according to research presented at ESC Preventive Cardiology 2022, a scientific congress of the European Society of Cardiology.

7 Apr 2022

Researchers design RNA molecules for delivering therapies directly to beta cells

Investigators at the University of Miami Miller School of Medicine have designed RNA molecules that home to human pancreatic beta cells, the cells that produce insulin and are destroyed in patients with type 1 and type 2 diabetes.

7 Apr 2022

KHN’s ‘What the Health?’: Finally, a fix for the ‘family glitch’

The Biden administration this week moved to fix the so-called family glitch in the Affordable Care Act, which has prevented dependents from getting federal subsidies to buy health insurance even if the insurance offered by the employer is unaffordable.

7 Apr 2022

Drugs News and Research

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

Artificial intelligence model could predict side effects resulting from new combination therapies

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

Researchers discover new mechanisms for bone loss in gum disease

Expanding statin prescription could be a cost-effective intervention against cardiovascular disease

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

Nanomedicine for treating life-threatening brain tumors

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Yale researchers discover immune response pathway that leads to severe COVID-19

Unique immune cell fingerprint can help rapidly identify better treatment for autoimmune disease

Nobel-prize-winning breakthrough: Discovery of ion-channel sensors for temperature and pressure

Smoking cessation could help heart disease patients gain five years of healthy life

Researchers design RNA molecules for delivering therapies directly to beta cells

KHN’s ‘What the Health?’: Finally, a fix for the ‘family glitch’

Evaluating the trustworthiness and characteristics of COVID-19-related trial preprints

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

Specialist assay kits and microplates for cancer research

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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