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"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Peptidomimetic antibiotics may be effective against resistant bacteria

Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.

1 Jun 2023

Key insights into immune responses after COVID-19 vaccination in Indigenous people

Researchers evaluated immune responses to COVID-19 BNT162b2 mRNA vaccinations among Indigenous Australian First Nations (FN) individuals by comorbidity and ethnicity.

1 Jun 2023

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

1 Jun 2023

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade (ICB) - a novel form of cancer treatment utilizing immune checkpoint inhibitors (ICIs) - and minimizes the associated side effects.

1 Jun 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

Spice up your heart health: Taurine and black pepper combo shows promising cardioprotective effects

Taurine and black pepper, along with key terpene constituents, are investigated for their potential in reducing cardiovascular risk factors and combating related diseases in this comprehensive literature review. Their cardioprotective effects and mechanisms are explored.

31 May 2023

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

New research has unlocked insights into how "good fat" tissue could potentially be harnessed to combat obesity and remove glucose from the blood, helping to control diabetes.

31 May 2023

First-in-human clinical trial of liver dialysis device successfully completed

The first successful in-patient trial of liver dialysis* has been completed by researchers from UCL, the Royal Free Hospital, UCL spin-out Yaqrit and their collaborators.

31 May 2023

Breast cancer patients experience more severe CIPN symptoms with paclitaxel

Chemotherapy-induced peripheral neuropathy (CIPN) – nerve pain, tingling, or numbness in the hands or feet – is a common side effect of certain cancer treatments, including two drugs frequently used to treat cancer – the taxanes paclitaxel and docetaxel.

31 May 2023

Groundbreaking 3D imaging unveils secrets of cilia

Study provides a comprehensive analysis of human primary cilia, uncovering their architectural features and functional implications in cellular processes. It highlights the importance of these sensory organelles in signaling, motility, and intercellular communication.

31 May 2023

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

31 May 2023

New insights into how axons grow could lead to effective therapies for blindness, paralysis

Injuries to the nerves can blind or paralyze because adult nerve cells don't regenerate their connections. Now, a team of UConn School of Medicine researchers report in Development that at least a small population of nerve cells exist in everyone that could be coaxed to regrow, potentially restoring sight and movement.

31 May 2023

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Researchers from Children's Hospital of Philadelphia, the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network, the Pacific Pediatric Neuro-Oncology Consortium, and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors.

31 May 2023

Autoantibodies against 'synaptic adhesion protein' can cause schizophrenia-related changes

Links have been reported between schizophrenia and proteins produced by the immune system that can act against one's own body, known as autoantibodies.

31 May 2023

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

This new article publication from Acta Pharmaceutica Sinica B, discusses click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries.

31 May 2023

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

UNIGE researchers identify how the influenza A virus manages to penetrate host cells

Influenza epidemics, caused by influenza A or B viruses, result in acute respiratory infection. They kill half a million people worldwide every year.

31 May 2023

Cellular Origins Launches Constellation, its Configurable Robotic Platform to Enable Scalable Manufacture of Advanced Therapies

A closed, fully automated, and configurable robotic platform for cell therapy manufacture can achieve 30-fold increase in space efficiency and reduces production costs and labor by 51% and 16-fold, respectively.

From Cellular Origins 31 May 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

B Cell News and Research

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Peptidomimetic antibiotics may be effective against resistant bacteria

Key insights into immune responses after COVID-19 vaccination in Indigenous people

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Spice up your heart health: Taurine and black pepper combo shows promising cardioprotective effects

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

First-in-human clinical trial of liver dialysis device successfully completed

Breast cancer patients experience more severe CIPN symptoms with paclitaxel

Groundbreaking 3D imaging unveils secrets of cilia

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

New insights into how axons grow could lead to effective therapies for blindness, paralysis

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Autoantibodies against 'synaptic adhesion protein' can cause schizophrenia-related changes

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

UNIGE researchers identify how the influenza A virus manages to penetrate host cells

Cellular Origins Launches Constellation, its Configurable Robotic Platform to Enable Scalable Manufacture of Advanced Therapies

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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