Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Research sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression

Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide.

3 Dec 2024

Ketone metabolism redefines protein quality control in aging brains

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

3 Dec 2024

Study highlights the critical role of TLR7 in sex-biased Alzheimer’s-related demyelination

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer's disease and ordinary aging, suggests a study led by researchers at Weill Cornell Medicine.

2 Dec 2024

Visceral fat found to contribute to Alzheimer's disease development

Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a study being presented today at the annual meeting of the Radiological Society of North America (RSNA).

2 Dec 2024

TRiC mutations found to cause developmental brain malformations in children

In 1992, Judith Frydman, PhD, discovered a molecular complex with an essential purpose in all of our cells: folding proteins correctly.

27 Nov 2024

Research shows "Alzheimer's in a dish" model can accelerate drug discovery

A decade ago, researchers introduced a new model for studying Alzheimer's disease. Known as "Alzheimer's in a dish," the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain over 10 to 13 years in just six weeks.

27 Nov 2024

Study unveils key mechanism in Alzheimer's disease

A new study from the University of Liverpool represents a significant step forward in scientists' understanding of Alzheimer's disease.

27 Nov 2024

Cardiovascular disease risk linked to early brain decline in men

Men with cardiovascular disease risk factors, including obesity, face brain health decline a decade earlier - from their mid 50s to mid 70s - than similarly affected women who are most susceptible from their mid 60s to mid 70s, suggest the findings of a long term study, published online in the Journal of Neurology Neurosurgery & Psychiatry.

26 Nov 2024

Machine learning tool detects early signs of Alzheimer's in mice

Subtle signs of Alzheimer's disease can emerge decades before a diagnosis - often in the form of irregular behaviors that reflect very early stages of brain dysfunction.

26 Nov 2024

Nasal spray shows promise in combating Alzheimer's

A future treatment for Alzheimer disease may involve a nasal spray. Researchers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS have discovered that by inhibiting the brain enzyme S-acyltransferase (zDHHC) through a nasal-spray drug, they can counteract the cognitive decline and brain damage typical of the disease.

26 Nov 2024

Addressing the challenges of cognitive impairment detection in primary care

Early detection of cognitive impairment is essential for improving patient outcomes, but primary care settings face significant challenges in screening. This special report summarizes key points and gaps in knowledge about methods for detecting cognitive impairment in primary care clinics.

25 Nov 2024

Brain volume loss linked to Alzheimer's treatment may be caused by amyloid plaque removal

A loss of brain volume associated with new immunotherapies for Alzheimer's disease may be caused by the removal of amyloid plaques, rather than the loss of neurons or brain tissue, finds a study led by UCL researchers.

25 Nov 2024

New study offers insights into reliable Alzheimer's diagnosis

A research group at LMU University Hospital has investigated how Alzheimer's disease can be diagnosed more reliably in the future.

25 Nov 2024

Researchers develop new approach to effectively deliver therapeutics into the brain

Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach - demonstrated in mouse models and isolated human brain tissue - to safely and effectively deliver therapeutics into the brain, providing new possibilities for treating a wide range of neurological and psychiatric diseases.

25 Nov 2024

From womb to midlife: Prenatal immune disruptions reshape memory and cognitive aging

Prenatal exposure to maternal pro-inflammatory cytokines shapes memory and immune function in offspring, with sex-specific effects emerging over 50 years.

24 Nov 2024

Pioneering protocol sheds light on NMDA receptor distribution in Alzheimer's brains

Researchers from the Institute for Neurosciences (IN), a joint center of the Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC), who are also part of the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Alicante Institute for Health and Biomedical Research (ISABIAL), have developed a cellular fractionation protocol.

22 Nov 2024

Alzheimer's Disease News and Research

Further Reading

Research sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression

Ketone metabolism redefines protein quality control in aging brains

Study highlights the critical role of TLR7 in sex-biased Alzheimer’s-related demyelination

Visceral fat found to contribute to Alzheimer's disease development

TRiC mutations found to cause developmental brain malformations in children

Research shows "Alzheimer's in a dish" model can accelerate drug discovery

Study unveils key mechanism in Alzheimer's disease

Cardiovascular disease risk linked to early brain decline in men

Machine learning tool detects early signs of Alzheimer's in mice

Nasal spray shows promise in combating Alzheimer's

Addressing the challenges of cognitive impairment detection in primary care

Brain volume loss linked to Alzheimer's treatment may be caused by amyloid plaque removal

New study offers insights into reliable Alzheimer's diagnosis

Researchers develop new approach to effectively deliver therapeutics into the brain

From womb to midlife: Prenatal immune disruptions reshape memory and cognitive aging

Pioneering protocol sheds light on NMDA receptor distribution in Alzheimer's brains

New neuroimaging marker may identify persons at risk of dementia in future clinical trials

Study links prenatal immune activity to Alzheimer's risk in later life

Study links historical education policies to better cognitive outcomes later in life

Researchers develop low cost, scalable methodology for early dementia detection

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