Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

New DBTL workflow may enable more efficient production of pharmaceutical raw materials

Researchers in Japan have developed an integrated synthetic biology system to construct new metabolic pathways and enzymes within microbes.

7 May 2019

Common foods linked to arterial stiffening in new metabolomics study

Researchers have identified several lifestyle factors that could cause arteries to stiffen and increase the risk of heart disease, two of which were peptides found in common foods.

7 May 2019

Study pinpoints lifestyle factors that contribute to arterial stiffness

A new study from the University of Georgia pinpoints lifestyle factors that could lead to hardened arteries.

6 May 2019

Scientists develop small fluorophores for tracking metabolites in living cells

Living cells can react to disturbances with a changed metabolism, but direct observation of trafficking metabolites in live cells is difficult.

30 Apr 2019

Brazilian researchers reveal bactericidal action mechanism of violacein

In an article published in the journal ACS Infectious Diseases, Brazilian researchers describe the bactericidal action mechanism of violacein, a violet pigment produced by environmental bacteria, especially Chromobacterium violaceum.

26 Apr 2019

Researchers explore whether time of day can affect the body's response to physical exertion

Two papers appearing April 18 in the journal Cell Metabolism confirm that the circadian clock is an important factor in how the body responds to physical exertion.

19 Apr 2019

A comprehensive, centralized database of bovine milk compounds

Milk is a staple of the human diet, full of key nutrients such as protein, carbohydrates, fats, and vitamins. Cow's milk in particular is one of the most-used dairy products globally, with over 800 million tons produced annually according to the United Nations Food and Agriculture Organization.

17 Apr 2019

Microbiome science may help doctors to improve treatment for children with IBS

To improve the treatment of children with irritable bowel syndrome, investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut.

17 Apr 2019

Molecule metabolite variations in breast milk may hold risk factors for childhood obesity

New research suggests the composition of breast milk in normal weight mothers differs from that of overweight mothers, and that variations in small molecule metabolites found in breast milk are possible risk factors for childhood obesity.

11 Apr 2019

Alcohol, Cannabis and Other Drugs: A Pharmacological Evaluation

Understanding the interactions between alcohol and cannabis can provide researchers, clinicians and other HCPs with important information on the severity of their side effects.

10 Apr 2019

GC-MS/MS of dried urine is a ‘good surrogate’ for serum testing of hormones

Researchers have shown that analyzing dried urine extracts with GC-MS/MS to assess levels of reproductive hormones in pre-and post-menopausal women provides similar results to radioimmunoassays using serum samples.

5 Apr 2019

Gut microbiome signatures in colorectal cancer transcend culture and diet

Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets -- a team of international researchers, from University of Copenhagen among others, find in a new study.

4 Apr 2019

New analysis establishes global microbial signatures for colorectal cancer

Cancers have long been known to arise due to environmental exposures such as unhealthy diet or smoking. Lately, the microbes living in and on our body have entered the stage as key players: while stomach cancer can be caused by a single bacterial species, Helicobacter pylori, the role that gut microbes play in the development of colorectal cancer - the third most common cancer worldwide - is less clear.

2 Apr 2019

Measuring estrogen byproducts can help predict survival for breast cancer patients

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center found preliminary evidence that measuring byproducts of the hormone estrogen can help them predict survival for women with breast cancer.

1 Apr 2019

Research uncovers crucial receptor involved in response to fast-acting antidepressants

Effective treatment of clinical depression remains a major mental health issue, with roughly 30 percent of patients who do not respond to any of the available treatments.

29 Mar 2019

Fetal exposure to nicotine linked with SIDS and cardiac arrhythmias in newborns

Fetal exposure to tobacco smoke in utero is associated with sudden infant death syndrome (SIDS) and cardiac arrhythmias in newborns. In a novel study in rabbits, investigators provide the first evidence linking fetal exposure to nicotine to long-term alterations of the cardiac sodium current.

29 Mar 2019

Tumor-associated macrophages block activity of chemotherapy drug in pancreatic cancer

A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug's action, research led by the University of Michigan Rogel Cancer Center found.

27 Mar 2019