Autoimmunity News and Research

RSS

Autoimmune Disease is a condition in which the body recognizes its own tissues as foreign and directs an immune response against them.

Paxlovid found ineffective for long COVID relief in new trial

Antiviral medications nirmatrelvir/ritonavir (Paxlovid) were not effective in relieving long COVID symptoms, according to a new study published in The Lancet Infectious Diseases on April 3.

7 Apr 2025

Study explores how sex chromosomes and hormones influence immune responses

Women have a higher proportion of key immune cells between puberty and menopause, which may be linked to the sex hormone estrogen and explain why they are less susceptible to certain infectious diseases than men, according to a new study led by researchers at UCL.

27 Mar 2025

COVID-derived molecular mimics may be involved in triggering autoimmunity

COVID infection has been linked to higher risk of autoimmune disorders, including rheumatoid arthritis and type 1 diabetes.

26 Mar 2025

Yale study unlocks potential of lupus-related antibody to target cold tumors

Yale scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into "cold" tumors and flip on an immune response that has been turned off by cancer.

25 Mar 2025

Study reveals key role of Treg cells in preventing autoimmune responses

During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and viruses from self-antigens that are expressed by cells of the body.

22 Mar 2025

New discovery unravels mystery behind overactive immune responses

Autoimmune diseases, which are estimated to affect more than 15 million people in the U.S., occur when the body responds to immune-system false alarms, and infection-fighting first responders are sent out to attack threats that aren't there.

18 Mar 2025

Lower doses of antibiotic doxycycline offer effective treatment for alopecia

Small amounts of a common antibiotic and anti-inflammatory drug can curb symptoms where a misplaced immune reaction (e.g., autoimmunity) can cause permanent hair loss, a new study shows.

18 Mar 2025

Regulating cell acidity could transform autoimmune disease treatments

What if treating autoimmune diseases was as simple as regulating the acidity levels of parts of patients' cells? Genetic screening may have unlocked a path for treating the severe inflammation associated with many immune diseases by regulating one protein's role in helping another protein control cell acidity, according to new research published in Cell by a team from the Perelman School of Medicine at the University of Pennsylvania.

11 Mar 2025

Misdiagnosis of autoimmune diseases leads to long-term patient impact

A 'chasm of misunderstanding and miscommunication' is often experienced between clinicians and patients, leading to autoimmune diseases such as lupus and vasculitis being wrongly diagnosed as psychiatric or psychosomatic conditions, with a profound and lasting impact on patients, researchers have found.

4 Mar 2025

Are Allogeneic CAR-Ts the Future of LBCL Cancer Treatment? - Making Safe, Durable & Effective Universal Cell Therapies a Reality

Allogene Therapeutics recently released exciting results from the Phase 1 ALPHA/ALPHA2 trials of the Allogeneic CAR T 'Cemacabtagene Ansegedleucel/ALLO-501' in Relapsed/Refractory Large B-Cell Lymphoma.

From Hanson Wade Group - 7th Allogeneic Cell Therapies Summit 4 Mar 2025

Genetic mutation offers hope for better rheumatoid arthritis treatments

Research led by York University's Faculty of Health reveals how a specific mutation in a protein called TRAF1 can shut down an overactive immune response, dramatically reducing inflammation in mice.

27 Feb 2025

LJI scientists discover a potential new target for treating Parkinson's disease

Scientists at La Jolla Institute for Immunology (LJI) have found a potential new target for treating Parkinson's disease.

25 Feb 2025

Machine learning algorithm decodes immune system’s hidden data for disease detection

Your immune system harbors a lifetime's worth of information about threats it's encountered - a biological Rolodex of baddies.

24 Feb 2025

New therapeutic cocktails show promise for long-lasting asthma relief

Current asthma treatments don't work in all patients, and they don't provide long-term relief from potentially deadly asthma attacks.

19 Feb 2025

SAB BIO announces positive topline Phase 1 clinical results with potentially disease-modifying T1D therapy SAB-142

SAB BIO, (“SAB BIO”), a clinical-stage biopharmaceutical company with a novel immunotherapy platform that is developing human anti-thymocyte immunoglobulin (hIgG) for delaying the onset or progression of type 1 diabetes (T1D), today announced positive topline data from a Phase 1 trial of SAB-142 in a single-ascending dose among healthy volunteers.

From SAb Biotherapeutics, Inc. 6 Feb 2025

Researchers discover key to boosting thymus regeneration after damage

A team of international researchers led by scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center in Los Angeles ranked among the nation's top 5 cancer centers by U.S. News & World Report, have demonstrated a way to boost thymic function after damage in preclinical studies.

3 Feb 2025

New AI tool promises faster vaccine development by predicting T cell epitopes

An exciting collaboration between the Ragon Institute and the Jameel Clinic at MIT has achieved a significant milestone in leveraging artificial intelligence (AI) to aid the development of T cell vaccine candidates.

29 Jan 2025

Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammation

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

17 Jan 2025

Scientists discover how viral infection triggers autoimmune disease

Scientists at the Garvan Institute of Medical Research have discovered how a viral infection causes autoimmune disease, disproving a long-standing theory and opening a promising new approach to developing treatments for autoimmune conditions.

16 Jan 2025

Cellular RNA enhances MAVS signalosome activation in antiviral immunity

Scientists have uncovered a new role for a cell's own RNA in fending off attacks by RNA viruses. Some of the cell's RNA molecules, researchers found, help regulate antiviral signaling. These signals are part of the intricate coordination of immune responses against virus invasion.

19 Dec 2024