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New study reveals how the glucocorticoid receptor forms complex structures inside cells

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

27 Oct 2025

Advancements and clinical translation of intelligent nanodrugs for breast cancer treatment

A comprehensive review in "Biofunct. Mater." meticulously details the most recent advancements and clinical translation of intelligent nanodrugs for breast cancer treatment.

24 Oct 2025

Novel molecule found to be a key player in kidney injury and repair

Chronic kidney disease (CKD) is a progressive condition in which the kidneys gradually lose their ability to filter waste from the blood.

23 Oct 2025

Researchers develop a novel approach to monitor CD8⁺ T cell activity over time

The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies.

21 Oct 2025

Machine learning advances drug discovery through generalizable models

The drug development pipeline is a costly and lengthy process. Identifying high-quality "hit" compounds-those with high potency, selectivity, and favorable metabolic properties-at the earliest stages is important for reducing cost and accelerating the path to clinical trials.

16 Oct 2025

How shifting antibodies fuel aging and the new therapies aiming to slow it

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, glycosylation changes, and Fc receptor pathways, it reveals immunoglobulins as both biomarkers and potential therapeutic targets in aging.

14 Oct 2025

New AI system revolutionizes drug design and vaccine development

The rapid advancement of artificial intelligence (AI) is transforming the field of structural biology. In May 2024, DeepMind and Isomorphic Labs launched AlphaFold 3 (AF3), a revolutionary AI system capable of predicting the 3D structures and interactions of proteins, nucleic acids, small molecules, ions, and other biomolecules with remarkable precision.

10 Oct 2025

New fluorescent molecule could be used to generate clearer images of tumors

MIT chemists have designed a new type of fluorescent molecule that they hope could be used for applications such as generating clearer images of tumors.

6 Oct 2025

Engineered CAR T cells show promise against solid tumors

Chimeric antigen receptor (CAR) T cell therapy, which uses a patient's own immune cells to fight cancer, has emerged as a powerful way to treat lymphoma and other blood cancers.

2 Oct 2025

Combining radiopharmaceuticals with targeted radiation improves progression-free survival in prostate cancer patients

A new clinical trial finds that people with a limited number of metastases from recurrent prostate cancer lived significantly longer without disease progression when they received a radiopharmaceutical drug before targeted radiation, compared with radiation alone.

29 Sep 2025

Single-cell RNA sequencing reveals key genes and potential targeted drugs for OA treatment

Researchers from the Department of Orthopedics at Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine have made significant strides in understanding the molecular mechanisms underlying osteoarthritis (OA).

26 Sep 2025

New quintuple agonist shows promise for treating obesity and type 2 diabetes

Much excitement has built in recent years on the new class of incretin drugs that include glucagon-like-peptide-1 inhibitor (single agonists such as semaglutide) and also dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists (dual agonists such tirzepatide).

21 Sep 2025

Advancing drug discovery with AI, generative chemistry, and 3D molecular design

Discover how AI, generative chemistry, and 3D molecular design are revolutionizing drug discovery.

From Optibrium Ltd. 18 Sep 2025

Triple negative breast cancer exploits lymph node niches to block immune defense

In almost all solid tumors - i.e. cancers with a solid tissue structure - the detection of tumor cells in the lymph nodes is considered a decisive marker for the progression of the disease.

16 Sep 2025

Study reveals how centenarians preserve youthful immune defenses

Researchers mapped immune cells from centenarians, their offspring, and younger controls across three cohorts using multi-omics single-cell profiling. They found that centenarians retain leaner helper pools but have enhanced cytotoxic and NK cell programs, along with reinforced NK–T communication networks.

15 Sep 2025

Texas Tech research team earns $3 million renewal to advance stroke therapy

Stroke research aims to understand the brain's self-protective and repair mechanisms. Gaining detailed insight into these mechanisms is crucial as such knowledge could lead to newly developed medications and interventions which mimic or engage the brain's self-protective/repair mechanisms, leading to innovative stroke therapies.

13 Sep 2025

Scientists uncover brain circuit that turns cravings into eating behavior

Researchers found that the bed nucleus of the stria terminalis integrates pleasure signals from central amygdala prodynorphin neurons and hunger signals from agouti-related peptide neurons to drive consumption. Manipulating this bed nucleus of the stria terminalis circuit bidirectionally altered food intake and body weight in mice.

11 Sep 2025

SLIT2 protein levels in the eye and blood linked to cognitive function

Neurocognitive impairments are classified by pathological changes with potential for destruction of neural tissue. One change known to occur in neurodegenerative disorders is an accumulation of proteins causing pathological damage.

11 Sep 2025

Tarlatamab and anti-PD-L1 therapy combination demonstrates manageable safety profile in first-line ES-SCLC

Clinical data presented today demonstrates the combination of tarlatamab with anti-PD-L1 therapy as first-line maintenance has an acceptable safety profile and resulted in unprecedented overall survival in patients with extensive-stage small cell lung cancer (ES-SCLC).

8 Sep 2025

New protein-based therapeutic tool could change the way we treat diseases

A team of scientists at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) has created a protein-based therapeutic tool that could change the way we treat diseases caused by harmful or unnecessary cells.

3 Sep 2025