Spleen News and Research

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Egr-1 gene identified as crucial regulator of regulatory T cells in multiple sclerosis

Autoimmune diseases, such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA), affect millions of people worldwide.

11 Jul 2025

Novel combination therapy targets m6A pathway to combat joint erosion in rheumatoid arthritis

A recent study published in Engineering has shed light on a novel combination therapy for rheumatoid arthritis (RA) that significantly reduces bone destruction by targeting the m6A methylation pathway.

24 Jun 2025

Myeloid cells shape tumor microenvironments and influence cancer progression

Recent advances in cancer research have underscored the critical role of myeloid cells in shaping tumor microenvironments (TME), influencing tumor progression, immune evasion, and therapeutic resistance.

3 Jun 2025

MUSC creates protocol to improve emergency care for pediatric sickle cell patients

The Pediatric Emergency Medicine and Pediatric Hematology/Oncology divisions at the Medical University of South Carolina (MUSC) joined forces to create and test an algorithm for treating children with sickle cell disease who present to the Emergency Department (ED) with a fever.

28 May 2025

Sucralose disrupts male fertility by damaging sperm and altering hormones in animal study

Researchers found that chronic sucralose exposure in male rats disrupted reproductive hormones, damaged sperm, and impaired testicular function through oxidative stress and autophagy dysregulation. These findings raise concerns about the reproductive risks of high sucralose intake and its persistent presence in the environment.

19 May 2025

Inhaled microplastics suppress pulmonary macrophages critical to the immune system

Microplastics are ubiquitous in the environment, and we all routinely inhale these tiny pollutants. Now new research published at the ATS 2025 International Conference has found that inhaled microplastics suppress pulmonary macrophages, a type of white blood cell found in the lungs that are critical to the immune system.

19 May 2025

USPSTF urges universal syphilis screening in pregnancy to prevent congenital infections

The US Preventive Services Task Force (USPSTF) reaffirms its recommendation for universal syphilis screening in pregnancy, citing strong evidence for early detection and prevention of congenital syphilis. Despite ongoing disparities and rising rates, early screening and treatment remain essential to improving outcomes for mothers and infants.

18 May 2025

Malaria parasite found to evade the immune system by shutting down key genes

Researchers at Weill Cornell Medicine have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body's immune system, sometimes for years.

16 May 2025

AI tools improve detection of key immune structures in melanoma

Researchers from the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) have applied AI-driven processes for detecting tertiary lymphoid structures (TLS) in thousands of digital images of melanoma tumor tissue, significantly enhancing TLS identification and survival predictions for operable stage III/IV patients.

24 Apr 2025

Powerful imaging technique developed to study bone marrow in mouse models

Indiana University School of Medicine scientists have developed a powerful new imaging technique to study bone marrow in mouse models.

24 Apr 2025

Statins linked to better survival in blood cancer patients

Patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who were taking cholesterol-lowering statin medications at the start of their cancer treatment had a 61% lower risk of dying from their cancer compared to similar patients who were not taking statins, according to a study published today in the journal Blood Advances.

23 Apr 2025

Experimental cancer drug shows promise in boosting tuberculosis treatment

An experimental drug now in clinical trials as a cancer treatment could help boost the power of first-line tuberculosis (TB) treatments by helping infected cells die a gentler death, Johns Hopkins Medicine investigators report, based on mouse-model research of the lung-damaging disease.

21 Apr 2025

Rivaroxaban shown to be a viable alternative to warfarin for left ventricular thrombus

At three months of follow-up, patients hospitalized for a serious heart attack who were treated with the oral blood thinner rivaroxaban for a blood clot in the left ventricle did as well as similar patients who received standard treatment with warfarin, an older blood-thinning drug.

29 Mar 2025

Machine learning model outperforms traditional methods in myelofibrosis risk stratification

A machine learning model generated by a team from the European Society for Blood and Marrow Transplantation (EBMT) outperformed standard statistical models in identifying and stratifying transplant risk for patients with myelofibrosis, according to new research published today in Blood, the American Society of Hematology's flagship journal.

27 Mar 2025

Spleen News and Research

Egr-1 gene identified as crucial regulator of regulatory T cells in multiple sclerosis

Novel combination therapy targets m6A pathway to combat joint erosion in rheumatoid arthritis

Myeloid cells shape tumor microenvironments and influence cancer progression

MUSC creates protocol to improve emergency care for pediatric sickle cell patients

Sucralose disrupts male fertility by damaging sperm and altering hormones in animal study

Inhaled microplastics suppress pulmonary macrophages critical to the immune system

USPSTF urges universal syphilis screening in pregnancy to prevent congenital infections

Malaria parasite found to evade the immune system by shutting down key genes

AI tools improve detection of key immune structures in melanoma

Powerful imaging technique developed to study bone marrow in mouse models

Statins linked to better survival in blood cancer patients

Experimental cancer drug shows promise in boosting tuberculosis treatment

Rivaroxaban shown to be a viable alternative to warfarin for left ventricular thrombus

Machine learning model outperforms traditional methods in myelofibrosis risk stratification

Natural product derivative demonstrates promising therapeutic potential for psoriasis

High-salt diet induces depression-like symptoms in mice

Earlier ACL surgery may reduce risk of knee osteoarthritis

Targeted nanoparticles show promise in preventing pancreatic cancer spread to the liver

Researchers uncover pathways of bacterial spread in the bloodstream

Can red ginseng prevent diabetes? New research uncovers its potential

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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