Respiratory News and Research

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New bioengineered lung model could help scientists to advance research in lung conditions

An interdisciplinary team of researchers from McMaster and SickKids are developing a cutting-edge lung model that can better respond to viruses and drug treatments, giving scientists a tool to advance research in lung conditions like COVID-19, cystic fibrosis and allergens for asthma and air pollution.

18 Aug 2021

P681R spike mutation enhances replication efficiency of SARS-CoV-2 delta variant

A team of scientists from the University of Texas, USA, has recently revealed that the P681R spike mutation is responsible for increased infectivity of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The P681R spike mutation increases the replication of the delta variant by increasing the dissociation of S1 and S2 subunits at the furin cleavage site. The study is currently available on the bioRxiv* preprint server.

18 Aug 2021

Study investigates airborne and fomite transmission of SARS-CoV-2 in Syrian hamsters

National Institutes of Health scientists studying SARS-CoV-2, the virus that causes COVID-19, have defined in Syrian hamsters how different routes of virus exposure are linked to disease severity.

17 Aug 2021

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Researchers at the Children's Hospital Colorado Breathing Institute, the largest pediatric cystic fibrosis (CF) clinical care center in the U.S., participated in the pivotal international multi-center Phase 3 clinical trial, sponsored by Vertex Pharmaceuticals Incorporated, leading to FDA approval of TRIKAFTA (elexacaftor/tezacaftor/ivacaftor), a highly effective CF treatment, for patients ages 6 through 11 who have at least one copy of the F508del mutation.

17 Aug 2021

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

While gut microbiota play a critical role in the induction of adaptive immune responses to influenza virus infection, the role of nasal bacteria in the induction of virus-specific adaptive immunity is less clear.

17 Aug 2021

‘Tainted’ blood: Covid skeptics request blood transfusions from unvaccinated donors

The nation's roiling tensions over vaccination against covid-19 have spilled into an unexpected arena: lifesaving blood transfusions.

17 Aug 2021

Researchers confirm the speed, simplicity and accuracy of new COVID-19 testing method

Researchers from the University of Birmingham, U.K., have confirmed the speed, accuracy, and simplicity of a novel, a highly sensitive testing method for COVID-19 that can be deployed at entertainment venues, airport arrival terminals, and in remote settings where clinical testing laboratories are not available.

17 Aug 2021

Making the nanobody big again for Cryo-EM

Researchers describe the method that allows high-resolution structure determination of small proteins by single-particle cryo-EM using a Legobody.

17 Aug 2021

In UK's 1st wave, 10% of COVID infections were acquired in hospitals

Their study published in The Lancet journal involved assessing the magnitude of hospital-acquired COVID-19 in the case of acute and long-term National Health Service (NHS) hospital facilities in the UK during the first wave of the pandemic.

17 Aug 2021

Data reinforces SAB-185’s potential to neutralize SARS-CoV-2 variants

A study, available on the pre-print server bioRxiv*, evaluated the neutralizing capacity of a fully human polyclonal antibody (SAB-185) against the Delta, Kappa, and Lambda variants using a lentiviral-based pseudovirus assay.

17 Aug 2021

How delta and kappa variants of SARS-CoV-2 evade the immune system

A new study, available on the bioRxiv* preprint server, describes the neutralizing ability of the monoclonal antibodies against the variants and the difference of the ACE2 binding affinity found in the variants.

17 Aug 2021

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Now, a new study posted to the bioRxiv* preprint server focuses on functional immune memory to SARS-CoV-2, up to nine months in a Southeast Asian cohort, in the absence of re-infection.

16 Aug 2021

Vaccinating previously infected induces more potent antibodies less susceptible to escape from SARS-CoV-2 variants

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, which has claimed more than 4.3 million lives worldwide. Even after implementing various measures, such as vaccination and social restrictions, SARS-CoV-2 and its variants of concern (VoC) leave the world's public health systems and economies in turmoil.

16 Aug 2021

Moderna COVID-19 vaccine safe and efficacious in adolescents according to a new study

The safety, immunogenicity, and efficacy of the vaccines in adolescents are largely unknown. Now, a new study published in the New England Journal of Medicine evaluates the safety and efficacy of the mRNA-1273 vaccine in adolescents (12-17 years of age).

16 Aug 2021

Tool for defining new SARS-CoV-2 spike nucleotide sequences to Pango lineage sets

In a recent study, a group of researchers determined the degree to which Pango lineages are distinguishable using spike-only nucleotide sequences.

16 Aug 2021

Real-time genomics to track SARS-CoV-2 help contain transmission in New Zealand

A recent study discusses how New Zealand rapidly employed real-time genomics to contain new COVID-19 cases.

16 Aug 2021

The newest disease detection tool for covid and beyond: Poop

Since reopening campus at the University of California-San Diego last summer, university officials have relied on the tried-and-true public health strategies of testing and contact tracing. But they have also added a new tool to their arsenal: excrement.

16 Aug 2021

Obtained SARS-CoV-2 immunity, naturally or via vaccination persists 12 months

In a research paper recently uploaded to the preprint server medRxiv* by Havervall et al. (August 12th, 2021), neutralizing antibody titers towards wild-type SARS-CoV-2 and several variants of concern in individuals having either been vaccinated or infected with mild COVID-19 one year earlier are assessed, finding a reduced neutralization capacity against some strains.

16 Aug 2021

Study reports the prevalence of different types of shock in COVID-19 patients

A new database analysis of critically ill patients with pneumonia related to COVID-19, published in the American Journal of Cardiology and conducted at Hackensack Meridian Hackensack University Medical Center (HUMC), is the first study to report the prevalence of different types of shock in patients with COVID-19.

16 Aug 2021

More than one in ten COVID-19 patients acquired the virus in a hospital during UK's first wave

More than one in ten COVID-19 patients in 314 UK hospitals caught the infection in hospital during the first pandemic wave say researchers conducting the world's largest study of severe COVID-19.

16 Aug 2021

Respiratory News and Research

New bioengineered lung model could help scientists to advance research in lung conditions

P681R spike mutation enhances replication efficiency of SARS-CoV-2 delta variant

Study investigates airborne and fomite transmission of SARS-CoV-2 in Syrian hamsters

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

‘Tainted’ blood: Covid skeptics request blood transfusions from unvaccinated donors

Researchers confirm the speed, simplicity and accuracy of new COVID-19 testing method

Making the nanobody big again for Cryo-EM

In UK's 1st wave, 10% of COVID infections were acquired in hospitals

Data reinforces SAB-185’s potential to neutralize SARS-CoV-2 variants

How delta and kappa variants of SARS-CoV-2 evade the immune system

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Vaccinating previously infected induces more potent antibodies less susceptible to escape from SARS-CoV-2 variants

Moderna COVID-19 vaccine safe and efficacious in adolescents according to a new study

Tool for defining new SARS-CoV-2 spike nucleotide sequences to Pango lineage sets

Real-time genomics to track SARS-CoV-2 help contain transmission in New Zealand

The newest disease detection tool for covid and beyond: Poop

Obtained SARS-CoV-2 immunity, naturally or via vaccination persists 12 months

Study reports the prevalence of different types of shock in COVID-19 patients

More than one in ten COVID-19 patients acquired the virus in a hospital during UK's first wave

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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