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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

EZH2 inhibition offers hope for fighting treatment-resistant cancers

The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases.

8 Mar 2025

Evaluating the combined effect of electroacupuncture and Chinese herbal medicine on gut microbiota in ALS patients

Recent studies have highlighted a link between amyotrophic lateral sclerosis (ALS) and gut microbiota. This prospective study aimed to evaluate the effects of electroacupuncture combined with Chinese herbal medicine on gut microbiota and metabolomics in ALS patients.

7 Mar 2025

Novel treatment approach shows promise for advanced HPV-negative head and neck cancer

Researchers from the University of Chicago Medicine Comprehensive Cancer Center demonstrated the potential of a novel treatment approach including immunotherapy to treat advanced human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC).

7 Mar 2025

Snoring regularly? Your diabetes risk jumps if you had gestational diabetes

Short sleep duration and frequent snoring significantly raise the risk of type 2 diabetes in women with prior gestational diabetes. Regular snoring is also linked to poorer glucose metabolism biomarkers.

6 Mar 2025

Study finds potential biomarker for joint inflammation in Crohn's disease

People with Crohn's disease and related joint inflammation linked to immune system dysfunction have distinct gut bacteria or microbiota, with the bacterium Mediterraneibacter gnavus being a potential biomarker, according to new study by Weill Cornell Medicine researchers.

5 Mar 2025

Maternal stress may disrupt infant gut health, study highlights long-term risks

Perinatal maternal stress may alter gut microbiota in mothers and infants, potentially increasing inflammatory bacteria linked to health risks. A scoping review highlights the need for better stress measurement and microbiome research.

3 Mar 2025

Novel mechanism of PDHX acetylation linked to hepatocellular carcinoma progression

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

3 Mar 2025

Lactylation in the heart reveals key insights into cardiac regeneration

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

28 Feb 2025

Scientists uncover how a sugar shield in brain blood vessels protects against aging and disease

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain barrier, leading to increased permeability, neuroinflammation, and cognitive decline in aging and neurodegenerative diseases.

27 Feb 2025

New study identifies effective blood tests for ALS diagnosis and monitoring

ALS, or amyotrophic lateral sclerosis, can sometimes be difficult to diagnose or to predict how quickly the disease is likely to progress. A new study helps determine which blood tests are best at identifying and monitoring ALS.

26 Feb 2025

LJI scientists discover a potential new target for treating Parkinson's disease

Scientists at La Jolla Institute for Immunology (LJI) have found a potential new target for treating Parkinson's disease.

25 Feb 2025

Advanced MRI uncovers lung abnormalities in children and teens with long COVID

An advanced type of MRI uncovers significant lung abnormalities in children and adolescents with long COVID, according to a new study published today in Radiology, a journal of the Radiological Society of North America .

25 Feb 2025

Early lung cancer diagnosis improved with ctDNA methylation biomarkers

Early diagnosis of lung cancer is a critical priority in clinical practice. It may help reduce the rate of lung-cancer-related mortality, extend disease-free survival, and allow patients to live without ongoing medical interventions and complications.

25 Feb 2025

New AI tool measures brain aging speed and predicts cognitive health

A new artificial intelligence model measures how fast a patient's brain is aging and could be a powerful new tool for understanding, preventing and treating cognitive decline and dementia, according to USC researchers.

24 Feb 2025

High GATA6 expression predicts improved outcomes in pancreatic cancer

This new review article highlights the crucial role of GATA6, a transcription factor, in pancreatic ductal adenocarcinoma (PDA). The article explores GATA6's dual role in cancer progression and its potential as a biomarker and treatment target.

24 Feb 2025

Interferon gamma persistence offers clues to Long COVID and potential therapies

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.

22 Feb 2025