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Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

A team of scientists from the USA and Canada has recently identified and characterized a novel small-molecule compound inhibitor of cellular serine protease TMPRSS2, which shows significant antiviral potency against emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 May 2021

Robust passive and active immunity found in infants born to COVID-19 positive mothers

A new study provides evidence that babies born to mothers who were COVID-19 positive two or more months before delivery are protected by maternal antibodies, besides mounting a robust immune response in case they contract the infection in the perinatal period.

5 May 2021

Key mechanism behind mutant p53 aggregation process is linked to cancer pathology

Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors.

5 May 2021

Study could pave way for new therapies for kidney disease

Our kidneys are charged with the extraordinary task of filtering about 53 gallons of fluid a day, a process that depends on podocytes, tiny, highly specialized cells in the cluster of blood vessels in the kidney where waste is filtered that are highly vulnerable to damage.

5 May 2021

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

In a paper recently uploaded to the preprint server medRxiv by Edward Málaga Trillo et al. (April 29th, 2021), these methods are tested in combination with CRISPR-Cas detection in the field, demonstrating a sensitivity and specificity of 93.8% and 99%, respectively.

4 May 2021

New genetically encoded sensor helps detect drugs of abuse

A genetically encoded sensor to detect hallucinogenic compounds has been developed by researchers at the University of California, Davis. Named psychLight, the sensor could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse. The work is published April 28 in the journal Cell.

29 Apr 2021

Texas A&M AgriLife receives grant to support research on bacteriophage therapy

The National Institute of Allergy and Infectious Diseases, NIAID, part of the National Institutes of Health, NIH, has awarded $2.5 million in grants to support research on bacteriophage therapy, and Texas A&M AgriLife Research is among the grant recipients.

29 Apr 2021

Scientists design 'smart' cellular biosensors for detecting SARS-CoV-2 spike

New research led by Hana El-Samad of the University of California, San Francisco, and the Chan-Zuckerberg Biohub confirmed the beneficial use of an antiviral therapeutic called SARSNotch, which uses a combination of the SynNotch platform and de-novo designed protein binders. SARSNotch uses sentinel T cells to detect and mount a genetic response toward the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

28 Apr 2021

Researchers discover elusive cell type in fish sensory organs

One of the evolutionary disadvantages for mammals, relative to other vertebrates like fish and chickens, is the inability to regenerate sensory hair cells.

26 Apr 2021

New imaging technique captures movies of receptors on the surface of living cells

A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children's Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs.

23 Apr 2021

DeNovix Announces 21 CFR Compliance Ready Software for Spectrophotometer / Fluorometer Products

DeNovix Inc. announces the launch of EasyApps Secure, a 21 CFR Part 11 Compliance Ready software option for the DS-11 Series range.

From DeNovix Inc. 23 Apr 2021

DeNovix Announces 21 CFR Compliance Ready Software for Spectrophotometer / Fluorometer Products

eNovix announces the launch of EasyApps® Secure - 21 CFR Part 11 compliance ready software for the multi-award winning DS-11 Series Spectrophotometer / Fluorometer.

22 Apr 2021

SARS-CoV-1 utilizes ORF3a protein to trigger viral release

Scientists in the USA – from the Johns Hopkins University and the University of Maryland – have recently uncovered the mechanism by which SARS-CoV-1 is released from the infected cells.

21 Apr 2021

Characterization of lab-produced neutralizing antibodies targeting SARS-CoV-2

A new study led by Hans-Martin Jäck of the Friedrich-Alexander University Erlangen-Nuremberg in Germany engineered clusters of neutralizing monoclonal antibodies using a transgenic mouse model. A unique characteristic for the antibodies was the different ways it bound to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the overall reduction in the viral spread for human ACE2.

21 Apr 2021

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Severe COVID-19 causes sepsis-like manifestations, intense lung injury, and multi-organ failure, all associated with the overproduction of pro-inflammatory cytokines. This "cytokine storm" directly correlates with poor prognosis in this subgroup of patients.

21 Apr 2021

New implantable tool images brain activity in 3D

Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used techniques such as functional magnetic resonance imaging, but this method cannot record neural activity with high spatial resolution or in moving subjects.

20 Apr 2021

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

A new study, released as a preprint on the bioRxiv* server, casts some light on the pathogenesis of acute and subacute neurological complications associated with COVID-19.

19 Apr 2021

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

An international team of researchers focused on the macrodomain part of the non-structural protein 3 (Nsp3) gene product that SARS-CoV-2 uses to overturn the host cell’s natural antiviral response. The team provided a template that can help develop novel antivirals that are direct-acting and can combat the current pandemic.

16 Apr 2021

Researchers develop a rapid method to assess thirdhand smoke contaminants in household fabrics

A study led by scientists at the University of California, Riverside, has found chemicals in thirdhand smoke, or THS, get extracted more readily from household fabrics in a humid environment than in a dry one.

16 Apr 2021

New plasmonic isothermal PCR technology can detect respiratory viral pathogens in 30 minutes

Researchers in South Korea developed a plasmonic isothermal recombinase polymerase amplification (RPA) array chip, the world's first plasmoinc isothermal PCR technology which can detect 8 types of pathogens (4 bacteria and 4 viruses) that cause acute respiratory infectious diseases in 30 minutes.

15 Apr 2021

Fluorescence News and Research

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

Robust passive and active immunity found in infants born to COVID-19 positive mothers

Key mechanism behind mutant p53 aggregation process is linked to cancer pathology

Study could pave way for new therapies for kidney disease

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

New genetically encoded sensor helps detect drugs of abuse

Texas A&M AgriLife receives grant to support research on bacteriophage therapy

Scientists design 'smart' cellular biosensors for detecting SARS-CoV-2 spike

Researchers discover elusive cell type in fish sensory organs

New imaging technique captures movies of receptors on the surface of living cells

DeNovix Announces 21 CFR Compliance Ready Software for Spectrophotometer / Fluorometer Products

DeNovix Announces 21 CFR Compliance Ready Software for Spectrophotometer / Fluorometer Products

SARS-CoV-1 utilizes ORF3a protein to trigger viral release

Characterization of lab-produced neutralizing antibodies targeting SARS-CoV-2

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

New implantable tool images brain activity in 3D

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

Researchers develop a rapid method to assess thirdhand smoke contaminants in household fabrics

New plasmonic isothermal PCR technology can detect respiratory viral pathogens in 30 minutes

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