Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

New clinical trial to test treatment that targets overactive immune response to COVID-19

For some COVID-19 patients, the body's immune response may be as destructive as the virus that causes the disease.

22 May 2020

Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia

As the world struggles to overcome the current COVID-19 pandemic with non-pharmacological interventions, in the absence of an effective drug or vaccine, existing immunomodulators are being repurposed. A new study published on the preprint server medRxiv* in May 2020 shows no clinical benefit to the use of one such drug, called interferon beta 1b (IFN beta1b).

22 May 2020

CDC plans nationwide antibody study to determine the magnitude of the coronavirus pandemic

The U.S. Centers for Disease Control and Prevention (CDC) plans to launch a nationwide study to track how the novel coronavirus is spreading across the country.

20 May 2020

Study: Certain inflammatory demyelinating diseases belong to different category than multiple sclerosis

An antibody appears to make a big difference between multiple sclerosis and other disorders affecting the protective myelin sheath around nerve fibers, report Tohoku University scientists and colleagues in the journal Brain.

19 May 2020

New and unexplored angle in the binding of SARS-CoV-2 to host cells

Researchers in the Netherlands, Cuba, and Italy have made important discoveries about the carbohydrate-mediated binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to host cell lectin receptors and host lung microbiota.

17 May 2020

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

A small study in Greece found that the clinically approved anti-inflammatory drug anakinra, used to treat rheumatoid arthritis, improved respiratory function in patients with severe coronavirus disease 2019 (COVID-19).

14 May 2020

Scientists discover how the iron chelator drives immune system to deal with TB

Although COVID-19 commands the headlines today, tuberculosis (TB) remains the biggest infection killer in the world and multiple drug resistant TB, which does not respond to regular antibiotics, continues to be a major threat to global health.

13 May 2020

Vaccine design can face specific challenges, say researchers

The goal of a vaccine is to trigger a response that safely protects against an infection and/or the burden of disease.

13 May 2020

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Scientists around the globe are working to identify approved and investigational drugs that can be repurposed to treat COVID-19.

13 May 2020

Research examines molecules derived from ticks as potential COVID-19 treatment option

UK-based biotechnology firm ILC Therapeutics is working alongside the University of Oxford to examine the use of Evasins – molecules derived from ticks – as a potential COVID-19 treatment option for patients whose lungs are badly damaged by the virus and face a critical juncture in recovery.

13 May 2020

Innovative approach turns 'cold' tumors 'hot' to improve cancer immunotherapy

Scientists from the Tumor Immunotherapy and Microenvironment research group led by Dr Bassam Janji at the Luxembourg Institute of Health Department of Oncology, and the Swedish pharma company Sprint Bioscience published the results of an innovative approach that turns “cold” tumors “hot”. “Cold”, immune-desert tumors are classically immunotherapy-resistant.

13 May 2020

Platelets can intensify inflammatory processes, study shows

Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes.

12 May 2020

New discovery may contribute to early identification of aggressive breast tumors

Immune system cells in the blood of breast cancer patients undergo alterations early in the disease course, according to a study published in the journal Clinical & Translational Immunology.

12 May 2020

Does cholesterol play a role in COVID-19?

A new study published on the preprint server bioRxiv in May 2020 suggests that the strikingly increased mortality in COVID-19 patients who are either old or also have high blood pressure, diabetes, cardiovascular disease is due to high tissue cholesterol levels. It also indicates the role of a healthy diet, by showing that polyunsaturated fatty acids (PUFA) in blood oppose the effects of cholesterol and thus the risk for severe COVID-19 symptoms.

12 May 2020

Indiana researchers identify new target for colorectal cancer immunotherapy

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy.

11 May 2020

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

A new case report released on the preprint server medRxiv* provides a detailed longitudinal analysis of the immune response associated with a fatal case of coronavirus disease (COVID-19). It highlights the need for addressing the source of hyper inflammation in the treatment approach.

10 May 2020

New discovery could end chronic rejection of transplanted organs

Chronic rejection of transplanted organs is the leading cause of transplant failure, and one that the field of organ transplantation has not overcome in almost six decades since the advent of immunosuppressive drugs enabled the field to flourish.

9 May 2020

Researchers discover new type of antigen-presenting immune cell

With a discovery that could rewrite the immunology textbooks, an international group of scientists, including the teams of Bart Lambrecht, Martin Guilliams, Hamida Hammad, and Charlotte Scott (all from the VIB-UGent Center for Inflammation Research) identified a new type of antigen-presenting immune cell.

8 May 2020

Low CD8 and NK cell counts in the lung linked to high SARS-CoV-2 ACE2 receptor levels

A new study published on the preprint server bioRxiv in April 2020 reports that low levels of specific immune cells, namely, CD8 T cells and NK cells, are linked to higher expression of the ACE2 molecule, which acts as a receptor for the CoV.

6 May 2020

Researchers discover a new way to reduce implant rejection

The team from the University of Nottingham's Schools of Pharmacy and Life Sciences have found that the surface shape (topography) and chemical composition of polymer materials can be changed to create materials that control the body's immune response.

4 May 2020

Macrophage News and Research

Further Reading

New clinical trial to test treatment that targets overactive immune response to COVID-19

Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia

CDC plans nationwide antibody study to determine the magnitude of the coronavirus pandemic

Study: Certain inflammatory demyelinating diseases belong to different category than multiple sclerosis

New and unexplored angle in the binding of SARS-CoV-2 to host cells

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

Scientists discover how the iron chelator drives immune system to deal with TB

Vaccine design can face specific challenges, say researchers

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Research examines molecules derived from ticks as potential COVID-19 treatment option

Innovative approach turns 'cold' tumors 'hot' to improve cancer immunotherapy

Platelets can intensify inflammatory processes, study shows

New discovery may contribute to early identification of aggressive breast tumors

Does cholesterol play a role in COVID-19?

Indiana researchers identify new target for colorectal cancer immunotherapy

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

New discovery could end chronic rejection of transplanted organs

Researchers discover new type of antigen-presenting immune cell

Low CD8 and NK cell counts in the lung linked to high SARS-CoV-2 ACE2 receptor levels

Researchers discover a new way to reduce implant rejection

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