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CMD-OPT model enables discovery of potent and selective RIPK2 inhibitor for acute liver injury

This new article publication from Acta Pharmaceutica Sinica B, discusses how a CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.

12 Jul 2025

Exploring the roles of orphan nuclear receptors in MASLD pathogenesis

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis.

12 Jul 2025

Hepatitis C treatment gaps persist for children and new mothers

As the opioid epidemic has worsened in the United States, prevalence of hepatitis C has also increased. Hepatitis C is a bloodborne virus that damages the liver.

11 Jul 2025

UCLA study may help explain why certain liver tumors return after thermal ablation

A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center may help explain why certain liver tumors return quickly after thermal ablation, a widely used minimally-invasive, image-guided technique that kills cancer cells by applying intense heat through a needle-like probe.

10 Jul 2025

How a simple blood test can forecast future health risks

Plasma proteomics reveals that the biological ages of key organs, especially the brain and immune system, strongly predict the risk of future disease and early death. These organ-specific “clocks” provide a new tool for identifying those at highest risk and personalizing preventive care.

10 Jul 2025

Does pomegranate seed oil really help your heart? New research weighs the evidence

This review explores the potential of punicic acid in pomegranate seed oil as a nutraceutical for cardiovascular health. While preclinical evidence is promising, robust human trials are needed to confirm its benefits.

10 Jul 2025

Large language models show promise in predicting liver cancer treatment response

A research team led by Prof. Hai Li from the Hefei Institutes of Physical Science, Chinese Academy of Sciences, has become the first to systematically explore how large language models (LLMs) can assist in predicting liver cancer treatment responses-offering a new path toward AI-powered precision medicine.

10 Jul 2025

Sticky cell coating boosts liver repair without the need for transplants

A new process could help to treat liver disease without needing an organ transplant, a new study reveals.

10 Jul 2025

Short-term exercise improves liver health by modulating amino acid metabolism

Metabolic-associated steatohepatitis (MASH) is an advanced and progressive liver disease that potentially causes cirrhosis and hepatocellular carcinoma.

10 Jul 2025

Combination therapy sets new survival standard for advanced biliary tract cancer

In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment for people with advanced biliary tract cancer (aBTC), researchers have shown that after three years more than twice as many study participants treated with durvalumab plus GemCis had survived compared to those treated with a placebo plus GemCis.

10 Jul 2025

Biological age of the brain emerges as a powerful predictor of longevity

The candles on your birthday cake don't tell the whole story. As anyone who ever attended a high-school reunion can tell you, some people age faster than others.

10 Jul 2025

Weight loss triggers cell renewal and fat recycling in human tissue

Scientists have produced the first detailed characterization of the changes that weight loss causes in human fat tissue by analyzing hundreds of thousands of cells.

10 Jul 2025

Malaria eradication in Suriname offers hope for Amazon neighbors

The declaration of Suriname as the first malaria-free Amazonian country by the World Health Organization should spur other countries in the region affected by illegal mining and high migration, say disease specialists.

9 Jul 2025

MIT develops implantable device to automatically release emergency glucagon

For people with Type 1 diabetes, developing hypoglycemia, or low blood sugar, is an ever-present threat. When glucose levels become extremely low, it creates a life-threatening situation for which the standard treatment of care is injecting a hormone called glucagon.

9 Jul 2025

Innovative genome editing approach could be the key to lifelong effective weight management

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight-loss drugs, doing away with injections in favor of a one-time treatment.

9 Jul 2025

Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness

In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine say they have shed new light on the location and function of power-generating waves on the covering, or membrane, of these cells.

9 Jul 2025

Genetically modified herpes virus shows promise against advanced melanoma

The herpes simplex virus type 1 (HSV-1), which affects almost two-thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.

9 Jul 2025

Multi-contaminant water treatment could prevent tens of thousands of cancer cases

Drinking water treatment that pursues a multi-contaminant approach, tackling several pollutants at once, could prevent more than 50,000 lifetime cancer cases in the U.S., finds a new peer-reviewed study by the Environmental Working Group.

8 Jul 2025

Study reveals altered gut microbiota profiles in elderly patients with acute hepatitis E

Gut dysbiosis has been reported in severe liver diseases. However, information on the impact of hepatitis E virus infection on the gut microbiota, and the association between enteric microbiota disturbances and acute hepatitis E (AHE), is limited, particularly in elderly patients with AHE (AHE-elderly).

8 Jul 2025

Aspartame triggers genetic changes tied to glioblastoma severity

Study shows aspartame affects gut microbiome and gene expression in glioblastoma, highlighting potential links to cancer progression and treatment strategies.

8 Jul 2025

Liver News and Research

CMD-OPT model enables discovery of potent and selective RIPK2 inhibitor for acute liver injury

Exploring the roles of orphan nuclear receptors in MASLD pathogenesis

Hepatitis C treatment gaps persist for children and new mothers

UCLA study may help explain why certain liver tumors return after thermal ablation

How a simple blood test can forecast future health risks

Does pomegranate seed oil really help your heart? New research weighs the evidence

Large language models show promise in predicting liver cancer treatment response

Sticky cell coating boosts liver repair without the need for transplants

Short-term exercise improves liver health by modulating amino acid metabolism

Combination therapy sets new survival standard for advanced biliary tract cancer

Biological age of the brain emerges as a powerful predictor of longevity

Weight loss triggers cell renewal and fat recycling in human tissue

Malaria eradication in Suriname offers hope for Amazon neighbors

MIT develops implantable device to automatically release emergency glucagon

Innovative genome editing approach could be the key to lifelong effective weight management

Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness

Genetically modified herpes virus shows promise against advanced melanoma

Multi-contaminant water treatment could prevent tens of thousands of cancer cases

Study reveals altered gut microbiota profiles in elderly patients with acute hepatitis E

Aspartame triggers genetic changes tied to glioblastoma severity

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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