Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Researchers develop new approach for studying Cryptosporidium in healthy human tissues

Washington State University researchers have developed a new approach for studying Cryptosporidium, a waterborne gastrointestinal parasite now recognized as one of the leading causes of potentially life-threatening diarrheal disease in young children worldwide.

26 Jun 2018

Researchers show feasibility of stem cell-derived organoids for developing gene therapy vectors

A new study that compared six of the most promising adeno-associated viral gene therapy vectors in human retinal organoid models showed clear distinctions in the efficiency of gene transfer to both retinal pigment epithelial and photoreceptor cells.

14 Jun 2018

International experts agree on need for human-relevant research to improve drug discovery

The average pre-approval cost of research and development for a successful drug is estimated to be US$2.6 billion and the number of new drugs approved per billion US dollars spent has halved roughly every 9 years since 1950.

8 Jun 2018

Researchers discover three genes that may have contributed to evolution of large human brain

Three genes involved in nerve cell generation in the brain emerged roughly 3.5 million years ago and may have contributed to the rapid evolution of the large human brain, Howard Hughes Medical Institute (HHMI) Investigator David Haussler and colleagues report on May 31, 2018, in the journal Cell.

1 Jun 2018

New 3D brain organoid may hold potential in drug discovery, disease modeling

Wake Forest Institute for Regenerative Medicine scientists have developed a 3D brain organoid that could have potential applications in drug discovery and disease modeling.

30 May 2018

Advances in Cell Lineage Analysis

Dr. Jan Phillip Junker discusses the applications of CRISPR-Cas9 in cell lineage analysis and the development of tomo-seq; a method to study the spatial organization of cells within whole organisms.

9 May 2018

Tissue-engineered islets used to treat sudden-onset type 1 diabetes in mice

Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice.

9 May 2018

Research shows that amniotic fluid contains stem cells of kidney origin

Amniotic fluid, the liquid surrounding the fetus, can be routinely obtained without harming the mother or the baby. Previously, Prof. Dr. Adjaye's team and others demonstrated that amniotic fluid contains mesenchymal stem cells with great differentiation and regenerative potential.

7 May 2018

Study to examine whether cannabidiol provides therapeutic benefit to children with autism

Researchers at University of California San Diego School of Medicine are preparing a first-of-its-kind, multidisciplinary investigation to determine if and how cannabidiol, a non-psychoactive compound found in the cannabis plant, provides therapeutic benefit to children with severe symptoms of autism spectrum disorder.

27 Apr 2018

Scientists improve growth of 3d brain models to better understand autism, dementia, schizophrenia

Salk Institute scientists recently have developed a method to make micro brain structures in the lab. These microbrain tissues are designated to be used in research for treatment of neurological diseases such as Alzheimer’s disease or Parkinson’s disease.

26 Apr 2018

UA researchers aim to predict and prevent fatal disease in premature babies

A new $1.9 million grant at the University of Arizona Steele Children's Research Center will help researchers discover ways to prevent a deadly disease that affects thousands of premature infants annually.

25 Apr 2018

Salk researchers develop new glioblastoma model using gene-edited organoids

Glioblastoma multiforme (GBM) is an incredibly deadly brain cancer and presents a serious black box challenge. It's virtually impossible to observe how these tumors operate in their natural environment and animal models don't always provide good answers.

25 Apr 2018

New 'lymphoma micro-reactor' device targets chemo-resistant tumors

Non-Hodgkin lymphoma, a cancer that is diagnosed in the U.S. more than 70,000 times annually, arises from overly proliferating immune cells within the body's lymph nodes, which are connected to a network of lymph vessels through which lymphatic fluid flows.

12 Apr 2018

New technique makes it possible to trace lineage of each cell

Every biology textbook states that cells are life's building blocks. But researchers are only now beginning to understand their diversity. Technologies such as RNA sequencing are revealing which genes are expressed in each individual cell.

9 Apr 2018

Scientists create organoids that could help guide bladder cancer treatment

Researchers have created patient-specific bladder cancer organoids that imitate many of the features of real tumors and may therefore be used to study how cancer evolves.

6 Apr 2018

Live-cell imaging capabilities of the InVi SPIM microscope announced by Luxendo

Luxendo, a Bruker company, today announced the extension of the InVi SPIM microscope to include full incubation capabilities, as well as flexible illumination and detection optics.

From Bruker 28 Mar 2018

Researchers identify salivary protein that protects the body from traveler's diarrhea

Researchers have identified a protein in saliva (histatin-5) that protects the body from traveler's diarrhea.

8 Mar 2018

Researchers describe important step toward gene therapy for patients with Sandhoff disease

Babies with the rare, deadly genetic disorder Sandhoff disease begin to miss developmental milestones just months after birth. Lacking muscle tone, they never learn to sit up, develop heads too large to lift and eventually suffer uncontrollable seizures. There is no cure.

22 Feb 2018

Tiny 'brains on chips' reveal mechanisms underlying brain's wrinkling process

Being born with a "tabula rasa" - a clean slate - in the case of the brain is something of a curse. Our brains are already wrinkled like walnuts by the time we are born. Babies born without these wrinkles - smooth brain syndrome - suffer from severe developmental deficiencies and their life expectancy is markedly reduced.

20 Feb 2018

Organ chip technology improves study of the intestine for personalized medicine

Researchers have developed an organ-on-a-chip device using donor-derived human intestinal cells that offers advantages over organoids and new possibilities for personalized medicine.

14 Feb 2018