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Study creates a new platform to study single-cell genomics of many diseases

Although advances in genetics and genomics reveal numerous disease-associated gene mutations, physicians and researchers still wrestle with the tricky challenge of linking those mutations to actual disease-causing processes.

22 Apr 2020

A new, potential treatment for nonalcoholic steatohepatitis with fibrosis

In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for clinical application.

21 Apr 2020

Gimsilumab trial starts in first US patient with ARDS and COVID-19

The first American patient with COVID-19 and acute respiratory distress syndrome (ARDS) has been put on the drug gimsilumab at Temple University Hospital, as part of the BREATHE clinical trial. The trial, sponsored by Roivant Sciences, will evaluate the effectiveness of intravenous gimsilumab in preventing death in patients with COVID-19 and ARDS.

16 Apr 2020

Discovery of T cells response spectrum could new shed light on immune diseases

The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer, and what goes wrong in immune diseases.

15 Apr 2020

Research suggests potential treatment target to slow lymphoma tumor growth

Researchers at the MDC observe the very early stages of blood vessel development in lymph node tumors.

7 Apr 2020

Brown fat cells can translate energy into heat in an unexpected way

When we are exposed to sufficient cold or exercise, small clusters of brown fat cells in our bodies begin to burn up energy.

6 Apr 2020

New study overturns ‘snapshot’ model of cell cycle accepted since 1974

Cells have a big decision: Should they replicate or sleep? Healthy cells can go either way. Cancer cells' replication switches are stuck in the 'on' position.

2 Apr 2020

Investigational oral form of treatment offers hope for adults with acromegaly

Adults who need medical maintenance treatment of the growth hormone disorder acromegaly respond well to an investigational oral form of the drug octreotide, investigators of the Chiasma OPTIMAL study reported.

31 Mar 2020

Researchers develop a 'cardiac patch with bioink' to repair the heart

The heart is the driving force of circulating blood in the body and pumps blood to the entire body by repeating contraction and relaxation of the heart muscles continuously.

30 Mar 2020

New in vivo priming strategy can be an effective means to enhance cardiac repair

Human stem cells have been regarded as one of the promising cell sources for cardiac regeneration therapy.

27 Mar 2020

A promising strategy to overcome drug resistance developed by blood cancer cells

In a collaborative study published in Blood Advances, a research group led by Beate Heissig at Juntendo University and Yousef Salama at An Najah University report a strategy to overcome drug resistance developed by blood cancer cells.

27 Mar 2020

Model that sheds light on severe Duchenne muscular dystrophy could pave the way for new therapies

Researchers have developed an experimental model of severe Duchenne muscular dystrophy that offers insight into the disease.

26 Mar 2020

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly monitored during the first month of therapy.

22 Mar 2020

Research demonstrates control mechanism of force-induced cell-to-cell attachment

Using the amphibian Xenopus laevis as a model, Drs. Noriyuki Kinoshita and Naoto Ueno from the National Institute for Basic Biology, Japan and Dr. Ileana Cristea from Princeton University, USA have demonstrated that physical forces, such as centrifugal force, enhance cell-to-cell attachment and increase the stiffness of embryonic tissues as a result of force-induced cell shape change.

18 Mar 2020

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

The signaling molecule interleukin-2 (IL-2) has long been known to have powerful effects on the immune system, but efforts to harness it for therapeutic purposes have been hampered by serious side effects.

17 Mar 2020

Scientists engineer silkworms to produce different variants of adhesion molecules

Silkworms are useful for more than just making strong and absorbent strings of silky thread for the textiles industry.

16 Mar 2020

Breast milk may help protect preemies from developing sepsis

A component of breast milk may help protect premature babies from developing sepsis, a fast-moving, life-threatening condition triggered by infection.

16 Mar 2020

Novel strategy to stop tumors from developing new blood vessels

Scientists at the National Institutes of Health and other institutions have devised a new strategy to stop tumors from developing the new blood vessels they need to grow.

11 Mar 2020

Omega-3 fatty acids may help prevent complications in women receiving breast implants

For women receiving breast implants during reconstructive or cosmetic breast surgery, scarring around the implant - called capsular contracture - is a common, costly, and painful complication.

26 Feb 2020

Consumption of milk products linked to breast cancers

According to a new study from researchers at the Loma Linda University Health, drinking milk regularly might be linked to breast cancer in women. The new study titled "Dairy, soy, and risk of breast cancer: those confounded milks," was published in the latest issue of the International Journal of Epidemiology today.

25 Feb 2020