Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

New molecular mechanism that regulates the sentinel cells of the immune system

A study suggests that it may be possible to regulate macrophages with drugs that modulate the nuclear receptor RXR.

3 Apr 2020

New type of immunotherapy shows promise for future treatment of ovarian cancer

Malignant ovarian cancer is insidious: Known and feared for vague and uncharacteristic symptoms that often mean the disease is discovered so late that on average only four out of six patients are still alive after five years.

26 Mar 2020

Excessive salt intake weakens the immune system

A high-salt diet is not only bad for one's blood pressure, but also for the immune system. This is the conclusion of a current study under the leadership of the University Hospital Bonn.

25 Mar 2020

A high salt intake impairs immune response, study suggests

A study has shown that a high salt intake inhibits the immune system’s ability to combat bacteria.

25 Mar 2020

Study explores genetic mechanisms underlying resistance to leishmaniasis

In an article published in Scientific Reports, researchers affiliated with the University of São Paulo in Brazil describe experiments performed with mice that show how genetic factors can determine whether an individual is susceptible or resistant to leishmaniasis.

24 Mar 2020

CAR macrophages can be used to effectively fight solid tumors

Chimeric antigen receptor (CAR) T cell therapy has been a game-changer for blood cancers but has faced challenges in targeting solid tumors.

23 Mar 2020

CNIC scientists identify inflammatory regulatory circuit controlled by endothelial cells in the eye

Researchers at the Centro Nacional de Investigaciones Cardiovasculares, working with an international network of scientists, have identified an inflammatory regulatory circuit in the eye controlled by a subtype of endothelial cells, the cells that line the interior of blood vessels.

21 Mar 2020

High iron levels in lung increase severity of asthma

A new study published in the European Respiratory Journal in March 2020 reports that the accumulation of iron in the cells of the lung exacerbates asthma symptoms and reduces lung function.

17 Mar 2020

Researchers discover a new mechanism of long-lasting pain relief

A group of researchers from Charité - Universitätsmedizin Berlin has discovered a new mechanism of long-lasting pain relief.

16 Mar 2020

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020.

13 Mar 2020

Combination of anti-cancer nanodrugs with Intralipid enhances therapeutic efficacy

Pairing chemotherapy nanodrugs with a nutritional supplement can lessen devastating side-effects while reducing the amount of the expensive drugs needed to treat cancer according to a study from Carnegie Mellon University and Taiwan's National Health Research Institutes.

10 Mar 2020

Levels of sBTLA proteins may be a marker of overall survival in patients with HCC

In the 2020 February 25 issue of Scientific Reports, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that levels of a circulating soluble immune checkpoint protein can be used as a potential marker to predict overall survival in patients with advanced HCC.

9 Mar 2020

Gut bacteria can boost effectiveness of cancer immunotherapy, mice study suggests

Could the response to cancer immunotherapy depend on bacteria that originate in the gut and travel to the tumor?

7 Mar 2020

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response.

5 Mar 2020

New approach may lead to targeted treatments for certain macrophages or their mechanisms

Can phagocytes act like a Trojan horse, transporting tumour cells within themselves and thereby causing metastases in cancer patients?

5 Mar 2020

UAB research reveals hydrogen sulfide as new culprit for deadly tuberculosis

A new culprit -- hydrogen sulfide -- has been found for the deadly infectious disease tuberculosis. Hydrogen sulfide gas is known for its rotten egg smell, yet it has normal physiological roles in the human body to communicate among cells.

3 Mar 2020

Research opens up new prospects for prevention and treatment of bacterial pneumonia

Researchers from the Lille Centre for Infection and Immunity, INRAE and from Brazilian (Belo Horizonte), Scottish (Glasgow) and Danish (Copenhagen) laboratories have shown for the first time in mice that perturbation of the gut microbiota caused by the influenza virus favors secondary bacterial superinfection.

3 Mar 2020

A protein critical for wound healing and neural repair following spinal cord injury identified

Plexin-B2, an axon guidance protein in the central nervous system (CNS), plays an important role in wound healing and neural repair following spinal cord injury (SCI), according to research conducted at the Icahn School of Medicine at Mount Sinai and published today in Nature Neuroscience. T

2 Mar 2020

Brain imaging may help predict when liquid biopsy will benefit individual glioblastoma patients

Tracking brain cancer with a blood test instead of a surgical biopsy may greatly improve quality of life for glioblastoma (GBM) patients and provide critical information for their care, but it is not feasible in all cases.

27 Feb 2020

Study sheds new light on the immune system’s ability to deal with co-infection

The body’s immune response to fungal infections changes when a patient is also infected by a virus, according to new research which investigated the two types of infection together for the first time.

26 Feb 2020

Macrophage News and Research

Further Reading

New molecular mechanism that regulates the sentinel cells of the immune system

New type of immunotherapy shows promise for future treatment of ovarian cancer

Excessive salt intake weakens the immune system

A high salt intake impairs immune response, study suggests

Study explores genetic mechanisms underlying resistance to leishmaniasis

CAR macrophages can be used to effectively fight solid tumors

CNIC scientists identify inflammatory regulatory circuit controlled by endothelial cells in the eye

High iron levels in lung increase severity of asthma

Researchers discover a new mechanism of long-lasting pain relief

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

Combination of anti-cancer nanodrugs with Intralipid enhances therapeutic efficacy

Levels of sBTLA proteins may be a marker of overall survival in patients with HCC

Gut bacteria can boost effectiveness of cancer immunotherapy, mice study suggests

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

New approach may lead to targeted treatments for certain macrophages or their mechanisms

UAB research reveals hydrogen sulfide as new culprit for deadly tuberculosis

Research opens up new prospects for prevention and treatment of bacterial pneumonia

A protein critical for wound healing and neural repair following spinal cord injury identified

Brain imaging may help predict when liquid biopsy will benefit individual glioblastoma patients

Study sheds new light on the immune system’s ability to deal with co-infection

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