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Why the form of vitamin B12 you take may matter more than your intake

This comprehensive review examines vitamin B12 absorption, physiological roles, deficiency states, and dietary sources, with particular attention to differences between natural and synthetic forms. The authors conclude that while all B12 forms raise circulating levels, methylcobalamin may offer advantages in specific clinical contexts, especially where absorption or metabolic conversion is impaired.

10 Dec 2025

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

In an international study led by UCLA, researchers have shown that giredestrant, a next-generation oral selective estrogen receptor antagonist and degrader (SERD), when given as an adjuvant therapy for early-stage (1-3) hormone receptor (HR)-positive, HER2-negative breast cancer, significantly lowered the risk of the disease returning when compared with standard hormone therapies long considered the backbone of treatment.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

TXA reduces the need for blood transfusion in patients undergoing high-risk non-cardiac surgery

When hospitals were randomly assigned to treat patients undergoing higher-risk non-cardiac surgery with tranexamic acid (TXA) or a placebo, patients who received TXA needed significantly fewer blood transfusions and saw no increase in potentially life-threatening blood clots (thrombosis) after 90 days of follow-up, according to research presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.

9 Dec 2025

Unified EEG imaging method improves accuracy in identifying epileptogenic zones

A new advance from Carnegie Mellon University researchers could reshape how clinicians identify the brain regions responsible for drug-resistant epilepsy.

8 Dec 2025

AI method could help clinicians accurately identify brain tumors and radiation necrosis

While targeted radiation can be an effective treatment for brain tumors, subsequent potential necrosis of the treated areas can be hard to distinguish from the tumors on a standard MRI.

8 Dec 2025

Researchers explore brain activity linking nicotine withdrawal and pain sensitivity

Abstinent smokers experience increased pain sensitivity during withdrawal, to the point that they often require more pain relief after surgery.

8 Dec 2025

Simple blood and urine tests could spare febrile infants from more invasive procedures

New evidence from a six-country study led by the Montreal Children's Hospital and Children's National Hospital shows simple blood and urine tests could spare many young infants with fevers from more invasive procedures.

8 Dec 2025

Novel wireless device uses light to send information directly to the brain

In a new leap for neurobiology and bioelectronics, Northwestern University scientists have developed a wireless device that uses light to send information directly to the brain - bypassing the body's natural sensory pathways.

8 Dec 2025

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

It's not often that a pathologist gets to make a diagnosis that works for the patient by preventing treatment from occurring.

8 Dec 2025

Walking speed before surgery predicts who thrives after hip replacement

This study shows that preoperative gait speed is a strong predictor of patient-reported pain relief, function, and joint awareness after total hip arthroplasty for osteoarthritis. A walking speed of at least 1.0 m/s before surgery independently predicts excellent postoperative outcomes.

7 Dec 2025

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

5 Dec 2025

Higher PFAS levels reduce blood sugar improvements after teen bariatric surgery

A new USC study shows teens with higher blood levels of per- and polyfluoroalkyl substances (PFAS) measured before bariatric surgery had smaller improvements in blood sugar over five years, including fasting glucose and hemoglobin A1c (HbA1c), which measures average blood sugar levels over the past 60-90 days.

4 Dec 2025

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

A new study published in the American Journal of Physiology - Heart and Circulatory Physiology reveals that chronic kidney disease (CKD) accelerates cognitive decline through interconnected damage to the heart and brain-and that these pathways differ markedly between men and women.

4 Dec 2025

Common childhood virus linked to bladder cancer later in life

Tackling a common childhood virus could open the door to preventing bladder cancer, according to new research funded by Kidney Research UK and York Against Cancer.

4 Dec 2025

Current state, challenges, and future directions of heart transplantation in USA and Western Europe

In nearly 60 years, heart transplantation has transformed from a daring vision to an established surgical procedure. Since the first adult heart transplant in the United States was performed at Stanford Hospital in 1968, the field has made significant strides.

4 Dec 2025

Injectable scaffold vaccine shows strong protection against implant-related MRSA

Research reveals that silica scaffolds can train the immune system against S. aureus, offering a novel approach to prevent orthopedic device infections.

4 Dec 2025

Quicker access to Stop the Bleed program could have saved dozens of Maryland homicide victims

Quicker access to bleeding control interventions taught in the American College of Surgeons (ACS) Stop the Bleed program could have prevented the deaths of numerous homicide victims in Maryland, according to a first-of-its-kind analysis published in the Journal of the American College of Surgeons (JACS).

3 Dec 2025

Prehabilitation helps reduce disability after surgery in frail older adults

A large clinical trial published in JAMA Surgery shows that prehabilitation (also called prehab) can reduce disability after surgery in older adults with frailty, provided they are able to fully take part in the prehab program.

3 Dec 2025

New investment aims to accelerate treatments for low-grade brain tumors

Researchers focused on accelerating and testing new treatments for low-grade brain tumors are set to receive a transformative £2.8 million to drive their future work.

3 Dec 2025

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Surgery News and Research

Why the form of vitamin B12 you take may matter more than your intake

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

Triaptosis could be a promising strategy in the fight against cancer

TXA reduces the need for blood transfusion in patients undergoing high-risk non-cardiac surgery

Unified EEG imaging method improves accuracy in identifying epileptogenic zones

AI method could help clinicians accurately identify brain tumors and radiation necrosis

Researchers explore brain activity linking nicotine withdrawal and pain sensitivity

Simple blood and urine tests could spare febrile infants from more invasive procedures

Novel wireless device uses light to send information directly to the brain

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

Walking speed before surgery predicts who thrives after hip replacement

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Higher PFAS levels reduce blood sugar improvements after teen bariatric surgery

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

Common childhood virus linked to bladder cancer later in life

Current state, challenges, and future directions of heart transplantation in USA and Western Europe

Injectable scaffold vaccine shows strong protection against implant-related MRSA

Quicker access to Stop the Bleed program could have saved dozens of Maryland homicide victims

Prehabilitation helps reduce disability after surgery in frail older adults

New investment aims to accelerate treatments for low-grade brain tumors

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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