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Impact of engineered ACE2-Fc on SARS-CoV-2 infection

Researchers employ a structure-guided approach for the development of a series of ACE2-Fc variants using human IgG1 or IgG3 backbone.

1 Dec 2021

Structure function analysis of potent antibodies against Beta SARS-CoV-2 variant

A team of researchers from UK and US institutions created a large panel of mAbs derived from memory B cells of convalescent Beta subjects to better understand the antigenic landscape of Beta.

1 Dec 2021

Impact of SARS-CoV-2 on oral health

New research examined SARS-CoV-2 and its impact on oral health and suggests that survival against the infection may be partially dependent on such factors.

1 Dec 2021

Role of interferon type I-driven responses associated with disease control in COVID-19

New research suggests that treatment with type I interferons in the early stage of COVID-19 may supress disease progression by limiting SARS-CoV-2 in hosts.

1 Dec 2021

An antiviral regimen based on biomimetic polymers for COVID-19

In a new study published on the bioRxiv* preprint server, scientists proposed the aforementioned mechanism of action (MOA) and have validated it using electron photomicrographs of murine cytomegalovirus (MCMV), which were incubated with a nanoviricide.

30 Nov 2021

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

A new paper deals with the identification of an antiviral compound that could help in developing additional drugs to help fight COVID-19.

30 Nov 2021

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

In a recent study, published on the bioRxiv* preprint server, researchers identified human LRRC15 as an inhibitory receptor for SARS-CoV-2 entry, which directly binds to the receptor-binding domain (RBD) of the spike protein with a moderate affinity and inhibits spike-mediated entry.

29 Nov 2021

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Researchers found that virus-like particles produced by co-expression of SARS-CoV-2 S, membrane, envelope, and nucleocapsid proteins contain S glycoproteins, which are modified by complex carbohydrates.

29 Nov 2021

Extended host range for SARS-CoV-2 variants of concern

Researchers used viral pseudotyping to examine whether variants of concern had different host ACE2 receptor usage patterns.

29 Nov 2021

Immunity found 6 months after SARS-CoV-2 infection in children

A new study suggests that infection-induced antibodies persist, providing protection for at least six months.

29 Nov 2021

Study shows plasmacytoid dendritic cells may be a viable target for protection against SARS-CoV-2

A recent research paper by scientists from Denmark reveals that circulating plasmacytoid dendritic cells may be a potential therapeutic target to maintain desired levels of an antiviral compound known as interferon, allowing for the mitigation of coronavirus disease (COVID-19) severity. The study is currently available on the bioRxiv* preprint server while it undergoes peer review.

28 Nov 2021

The introduction and rapid spread of SARS-CoV-2 Gamma in Venezuela

Researchers from the Instituto Venezolano de Investigaciones Científica investigate the introduction of one of the VOCs into Venezuela.

28 Nov 2021

SARS-CoV-2 Omicron variant: What we know so far

On November 24, 2021, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant was first reported to the World Health Organization (WHO) from South Africa.

28 Nov 2021

Efficacy and safety of an RBD-based recombinant protein COVID-19 vaccine

A study developed a protein-based subunit vaccine, PHH-1V, that consisted of a recombinant RBD fusion heterodimer of the alpha) and beta variants of SARS-CoV-2.

26 Nov 2021

Researchers reveal possible role for anti-idiotype antibodies in long-term effects of COVID-19

With around 256 million cases and more than 5 million deaths worldwide, the COVID-19 pandemic has challenged scientists and those in the medical field.

25 Nov 2021

COVID-19 vaccine boosters to prevent breakthrough SARS-CoV-2 infections in healthy adults

Researchers measured anti-RBD IgG and virus neutralization before and after vaccination with boosters.

25 Nov 2021

SARS-CoV-2 Delta variant mutation sites

A new review article dissected the sites of mutation in the RBD of the Delta variant and other variants of concern and variants of alert and interest.

25 Nov 2021

Can COVID-19 affect erectile function?

Researchers discuss the underlying mechanisms through which COVID-19 can affect erectile function.

24 Nov 2021

Acute SARS-CoV-2 infection during pregnancy associated with placental ACE2 shedding

A new study, published on the bioRxiv* preprint server, hypothesized that ACE-2 expression and ADAM17 activity in the placenta is affected by the timing of SARS-CoV-2 infection of the mother.

24 Nov 2021

Study finds rhinovirus reduces SARS-CoV-2 replication in airway epithelial cells

A recent study has demonstrated that SARS-CoV-2 infection induces a significantly lower interferon response than rhinovirus infection.

24 Nov 2021

ACE2 News and Research

Impact of engineered ACE2-Fc on SARS-CoV-2 infection

Structure function analysis of potent antibodies against Beta SARS-CoV-2 variant

Impact of SARS-CoV-2 on oral health

Role of interferon type I-driven responses associated with disease control in COVID-19

An antiviral regimen based on biomimetic polymers for COVID-19

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Extended host range for SARS-CoV-2 variants of concern

Immunity found 6 months after SARS-CoV-2 infection in children

Study shows plasmacytoid dendritic cells may be a viable target for protection against SARS-CoV-2

The introduction and rapid spread of SARS-CoV-2 Gamma in Venezuela

SARS-CoV-2 Omicron variant: What we know so far

Efficacy and safety of an RBD-based recombinant protein COVID-19 vaccine

Researchers reveal possible role for anti-idiotype antibodies in long-term effects of COVID-19

COVID-19 vaccine boosters to prevent breakthrough SARS-CoV-2 infections in healthy adults

SARS-CoV-2 Delta variant mutation sites

Can COVID-19 affect erectile function?

Acute SARS-CoV-2 infection during pregnancy associated with placental ACE2 shedding

Study finds rhinovirus reduces SARS-CoV-2 replication in airway epithelial cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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