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Blocking iron-regulating enzyme triggers cancer cell death in multiple myeloma

Researchers at Duke University have shown that blocking an enzyme involved in iron regulation not only kills multiple myeloma cancer cells, but also increases the effectiveness of current therapies against the disease.

24 Sep 2025

Lifespan study reveals age-specific biological changes in Down Syndrome

In a groundbreaking new study published in Nature Communications, researchers from the Linda Crnic Institute for Down Syndrome (Crnic Institute) at the University of Colorado Anschutz discovered important differences in the physiological changes observed in over 300 individuals with Down syndrome across the lifespan.

24 Sep 2025

Reversing age-related vision loss with retinal lipid therapy

Changes in vision are often a common sign of aging. If you sit in a dimly lit restaurant with anyone over the age of 60, you'll likely hear the person say, "Hold on - let me pull out my cell phone. I need more light to read the menu!" But what if we could reverse age-related visual decline?

24 Sep 2025

How food choices and cooking methods drive brain inflammation and disease

Researchers reviewing evidence in NeuroSci show how dietary AGEs and their interaction with RAGE drive oxidative stress, inflammation, and neurodegeneration. They highlight how cooking methods and diet choices could lower AGE burden and protect brain health, while calling for rigorous clinical trials.

24 Sep 2025

Scientists outline how future therapies could change type 1 diabetes care

Researchers writing in The Lancet review breakthroughs in type 1 diabetes treatment, from immunotherapies that delay onset to stem-cell β-cell replacement and automated insulin delivery. They stress that equitable access, validated surrogate endpoints, and scalable technologies are crucial for lasting impact.

24 Sep 2025

Researchers identify protein crucial for tick-borne encephalitis virus to infect human cells

Researchers at Karolinska Institutet, together with international colleagues, have identified a protein that is crucial for the TBE virus to infect human cells.

24 Sep 2025

How DNA methylation changes during brain development influence autism and schizophrenia

Researchers at the University of Exeter have created a detailed temporal map of chemical changes to DNA through development and aging of the human brain, offering new insights into how conditions such as autism and schizophrenia may arise.

24 Sep 2025

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – from acne and psoriasis, to rheumatoid arthritis and inflammatory bowel disease.

24 Sep 2025

Groundbreaking discovery could transform leishmaniasis treatment

Leishmaniasis, a neglected tropical disease prevalent across 90 countries, affects approximately 12 million people worldwide, with 350 million more at risk of infection.

24 Sep 2025

Genomic study reveals colonial and Indigenous contributions to modern South Africans

A genomic analysis of over 1,200 people from across South Africa reveals how colonial-era European, Indigenous Khoe-San peoples, and enslaved people contributed to the modern-day gene pool in South Africa.

23 Sep 2025

Research highlights how the gut microbiome can affect epigenetics

The trillions of microbes that live in the human gut may play a bigger role in health than previously thought, according to a new research by the University of Hawaiʻi at Mānoa.

23 Sep 2025

Research shows different EML4-ALK variants drive lung cancer aggressiveness

About five percent of lung adenocarcinomas, one of the most common forms of lung cancer, are driven by a faulty fusion of two genes, EML4 and ALK.

23 Sep 2025

Wearable device uses AI and bioelectronics to personalize wound therapy

As a wound heals, it goes through several stages: clotting to stop bleeding, immune system response, scabbing, and scarring.

23 Sep 2025

UC Riverside receives $2 million grant to explore how gut bacteria shape human health

One day, bottles of probiotics might do more than keep you regular -- they could help prevent disease. To get there, a $2 million grant to UC Riverside will explore how gut bacteria shape human health.

23 Sep 2025

Fat distribution appears to influence cancer risk

How fat is distributed in people's bodies could make a difference to their risk of certain cancers, according to new research led by the University of Bristol. The international study is published in the Journal of the National Cancer Institute (JNCI) today [24 September].

23 Sep 2025

Senescent cell subtypes do not respond equally to treatment, study shows

A new research paper was published in Volume 17, Issue 8 of Aging-US on August 7, 2025, titled "Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction."

23 Sep 2025

New microfluidic-based biosensing platform helps track live antibody secretion dynamics

A research team at the Terasaki Institute, led by Dr. Vadim Jucaud in collaboration with Dr. Jing Yong Ye from the University of Texas San Antonio, has developed a new microfluidic-based biosensing platform that allows monitoring cellular secretion of monoclonal antibody in real time.

23 Sep 2025

Study reveals a new oncogenic role of NBL1 in ovarian cancer metastasis

Ovarian cancer (OC), one of the three most common gynecological malignancies, is characterized by low early detection rates and poor prognosis.

23 Sep 2025

Targeting miR-378 could offer a dual-action strategy against osteoporosis

Osteoporosis is a degenerative disease characterized by decreased bone mass and damage to bone microarchitecture, as well as increased bone fragility.

23 Sep 2025

Study provides new insights into understanding the origins of schizophrenia

A study published in Molecular Psychiatry and led by the EHU's Neuropsychopharmacology group, which is also a member of CIBER Mental Health (CIBERSAM) and of the Biobizkaia Health Research Institute, provides new insights into understanding the origins of schizophrenia.

23 Sep 2025