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Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Stephen Elledge, PhD, and his team did not set out to find therapies that could render tumors less resistant to therapy or make existing drugs more potent against a rare form of cancer. But these are precisely the clinical insights that their most recent study has yielded.

29 Aug 2018

New study reports key steps towards development of acne vaccine

A new study published in the Journal of Investigative Dermatology reports important steps that have been taken towards the development of an acne vaccine.

29 Aug 2018

Researchers receive $6 million NIH grant to improve treatment for Chagas disease

Scientists at The University of Texas at El Paso have received nearly $6 million from the National Institutes of Health to improve treatment and develop new diagnostic tools to assess post-therapeutic outcomes for patients with Chagas disease.

29 Aug 2018

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Hesperos, Inc., announced today the receipt of a NIH Phase I Small Business Innovation Research grant from the National Institutes of Health National Institute on Aging to help create a new multi-organ "human-on-a-chip" model that can realistically mimic the biology of Alzheimer's Disease and the effects of potential new therapies under realistic human physiological conditions.

29 Aug 2018

Researchers develop new software to improve success rates for image guided CRT

A team of specialists from King's College London, St Thomas' Hospital, and Siemens Healthineers have recently published details of a novel approach to lead placement during image guided cardiac resynchronization therapy.

29 Aug 2018

Researchers develop new approach to treating cancer using enzyme therapy

Researchers at The University of Texas at Austin have developed a new approach to treating cancer using enzyme therapy.

29 Aug 2018

Delivering miRNAs to treat patients with inflammatory bowel disease

Inflammatory bowel disease, such as Crohn disease and ulcerative colitis, are chronic inflammatory diseases of unknown cause, and the number of IBD patients is on the rise.

28 Aug 2018

New findings reveal potential role of interleukin-1 alpha in risk for heart attacks, strokes

XBiotech Inc. announced today the publication of findings that point toward a white blood cell-derived interleukin-1 alpha (IL-1⍺) as a cause of blood clots that could lead to heart attacks or strokes.

28 Aug 2018

Experts to discuss concepts, methods of gender medicine and their impact on oncology

Gender-based approaches to studying and treating disease have remained largely unexplored in medical oncology, despite the field's growing interest in precision medicine and accumulating evidence that sex is a major factor in disease risk and response to treatment.

28 Aug 2018

TB Alliance initiates SimpliciTB to test if new four-drug regimen can treat most types of tuberculosis

TB Alliance has initiated a pivotal clinical trial, SimpliciTB, that will evaluate whether a new four-drug regimen can treat most types of tuberculosis including multidrug-resistant TB more quickly and effectively than currently-available treatments.

28 Aug 2018

Immune-related enzymes cause aggressive skin cancer in patients with Butterfly Syndrome

Patients with a rare skin disease, commonly called Butterfly Syndrome, that causes chronic blistering and extensive scarring also develop an aggressive and fatal form of cancer early in life.

28 Aug 2018

Neuroscientists identify new type of “rose hip” neurons unique to humans

A unique type of neuron has been discovered in the human brain. It has been termed the “rose hip” neuron after the base of the rose which it resembles. This neuron is absent in mice and may provide clues about what makes the human brain unique.

27 Aug 2018

Amphetamine regimen does not improve post-stroke motor recovery

A pilot clinical trial exploring the benefit of d-amphetamine combined with physical therapy for stroke patients found no evidence that the regimen improved post-stroke motor recovery.

27 Aug 2018

Researchers explore wartime experiences and PTSD symptoms among female Air Force personnel

A study of deployed and non-deployed active duty, female Air Force personnel found that both rates of exposure to wartime experiences and reports of post-traumatic stress disorder (PTSD) increased between 2008 and 2013. Rates of post-deployment PTSD were highest among women who reported wartime experiences during deployment.

27 Aug 2018

Antithrombin drug does not reduce risk of myocardial infarction, stroke in heart failure patients

The antithrombin drug rivaroxaban does not reduce the risk of a composite endpoint of survival, myocardial infarction and stroke after an episode of worsening heart failure in patients with heart failure, sinus rhythm, and coronary artery disease, according to late breaking results from the COMMANDER HF trial presented today in a Hot Line Session at ESC Congress 2018 and with simultaneous publication in NEJM.

27 Aug 2018

New radiomic signature offers predictive score for efficacy of immunotherapy in patients

A study published in The Lancet Oncology establishes for the first time that artificial intelligence can process medical images to extract biological and clinical information.

27 Aug 2018

Aspirin appears to cause major bleeds and have no effect on cancers

Aspirin prevented serious vascular events in patients with diabetes who did not already have cardiovascular disease, but it caused almost as many major bleeds and there was no effect on cancers.

27 Aug 2018

Oral anticoagulant use after hospital discharge may offer protection from non-fatal blood clots

The use of an oral anticoagulant medicine in medically ill patients for 45 days following their discharge from the hospital reduces the rate of non-fatal symptomatic blood clots with no impact on fatal blood clots, according to late breaking results from the MARINER trial presented today in a Hot Line Session at ESC Congress 2018 and published in The New England Journal of Medicine.

27 Aug 2018

Study demonstrates cardiovascular safety of weight loss drug

A weight loss drug does not increase cardiovascular events, according to late breaking results from the CAMELLIA-TIMI 61 trial presented today in a Hot Line Session at ESC Congress and published in the New England Journal of Medicine.

27 Aug 2018

Fish oil supplements do not reduce risk of cardiovascular events in patients with diabetes

Fish oil supplements do not prevent heart attacks or strokes in patients with diabetes, according to late breaking results from the ASCEND trial presented today in a Hot Line Session at ESC Congress 2018 and published in the New England Journal of Medicine.

27 Aug 2018

Efficacy News and Research

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

New study reports key steps towards development of acne vaccine

Researchers receive $6 million NIH grant to improve treatment for Chagas disease

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Researchers develop new software to improve success rates for image guided CRT

Researchers develop new approach to treating cancer using enzyme therapy

Delivering miRNAs to treat patients with inflammatory bowel disease

New findings reveal potential role of interleukin-1 alpha in risk for heart attacks, strokes

Experts to discuss concepts, methods of gender medicine and their impact on oncology

TB Alliance initiates SimpliciTB to test if new four-drug regimen can treat most types of tuberculosis

Immune-related enzymes cause aggressive skin cancer in patients with Butterfly Syndrome

Neuroscientists identify new type of “rose hip” neurons unique to humans

Amphetamine regimen does not improve post-stroke motor recovery

Researchers explore wartime experiences and PTSD symptoms among female Air Force personnel

Antithrombin drug does not reduce risk of myocardial infarction, stroke in heart failure patients

New radiomic signature offers predictive score for efficacy of immunotherapy in patients

Aspirin appears to cause major bleeds and have no effect on cancers

Oral anticoagulant use after hospital discharge may offer protection from non-fatal blood clots

Study demonstrates cardiovascular safety of weight loss drug

Fish oil supplements do not reduce risk of cardiovascular events in patients with diabetes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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