Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Research finds synaptic strength key to maintaining memory in old age

Over the course of life, memory fades with varying degrees, robbing older people of the ability to recollect personal experiences.

7 Aug 2024

Study uncovers roles of certain brain cells in Alzheimer's plaque formation

A study in Nature Neuroscience found that both neurons and oligodendrocytes contribute to amyloid-β plaque burden in Alzheimer's disease, highlighting new therapeutic targets.

7 Aug 2024

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

6 Aug 2024

Cambridge experts question efficacy and practicality of new amyloid immunotherapy drugs

Cambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impact of Alzheimer's disease.

6 Aug 2024

Dopamine treatment can reduce Alzheimer's plaques and improve memory

A new way to combat Alzheimer's disease has been discovered by Takaomi Saido and his team at the RIKEN Center for Brain Science (CBS) in Japan.

6 Aug 2024

Social factors play crucial role in determining lifespan

The interplay of a quartet of sex, marital status, education, and race is linked to an 18 year lifespan gap for US citizens, and while no one factor is more influential than any of the others, the more of these influential factors a person has, the higher their risk of an earlier death, finds research published in the open access journal BMJ Open.

6 Aug 2024

Researchers receive $9.5M to study polyphenols' impact on cognitive health

UCLA Health researchers, in collaboration with researchers from the Republic of Ireland and Northern Ireland, have received $9.5 million award from the National Institutes of Health (NIH) with support from European funding agencies - The Science Foundation Ireland (SFI) and the Public Health Agency Health & Social Care (HSC) - to study the effects of polyphenols on cognitive health and the brain-gut microbiome system.

5 Aug 2024

FDA approves AChEI ALPHA-1062 for Alzheimer’s disease treatment

On July 29, 2024, the U.S. FDA approved Alpha Cognition Inc.'s ALPHA-1062 (Zunveyl®), an Acetylcholinesterase (AChE) inhibitor, for treating mild-to-moderate Alzheimer’s disease.

From Sino Biological Inc. 5 Aug 2024

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

Research highlights how cholesterol imbalances in the brain contribute to neurodegenerative diseases like Alzheimer's, Huntington's, and Parkinson's, suggesting targeted therapeutic interventions.

5 Aug 2024

New lab technique captures aging effects in Alzheimer's disease development

Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer's disease.

1 Aug 2024

Fish oil may benefit older adults with genetic Alzheimer's risk

A clinical trial at Oregon Health & Science University suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

1 Aug 2024

Targeting 14 modifiable risk factors from childhood to old age could prevent or delay dementia

Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, even as people around the world live longer and the number of people with dementia is set to rise dramatically in all countries, according to the third Lancet Commission on dementia prevention, intervention, and care, which is being presented at the Alzheimer's Association International Conference (AAIC 2024).

1 Aug 2024

Anticancer drugs show promise in reducing Alzheimer's dementia risk

Study finds anticancer drugs, specifically antimetabolites and molecular targeted therapies, may reduce the risk of Alzheimer's type dementia but not vascular dementia.

1 Aug 2024

Exosome-encapsulated fluorescent sensors enable advanced brain imaging in Alzheimer's research

Neurotransmitter levels in the brain can indicate brain health and neurodegenerative diseases like Alzheimer's.

31 Jul 2024

2024 is shaping up to be “the year of iPSCs"

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From Axol Bioscience Ltd 31 Jul 2024

Neurofilament light chain identified as early marker for Parkinson’s and dementia with Lewy Bodies

Early detection of Alzheimer's disease-related changes in Parkinson's disease and dementia with Lewy bodies could be made possible by monitoring the amyloid-β (Aβ) and phosphorylated tau (p-tau) proteins.

31 Jul 2024

High-resolution brain maps reveal vascular blueprint for healthy aging

Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer's disease, according to new study led by Penn State researchers. The findings point to an understudied but possible key role the brain's vascular network - or energy infrastructure - plays in the onset of neurodegenerative disease.

31 Jul 2024

Head-to-head comparison of commercial Alzheimer's blood tests reveals most accurate options

Neurologists diagnose cognitive impairment with a clinical exam of memory and thinking skills.

30 Jul 2024

Spatial patterns of cortical microstructural change can be early indicators of Alzheimer's disease risk

Findings from a novel study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier, suggest that using a specialized diffusion weighted MRI scan to monitor the spatial pattern of individual cortical microstructural change in the brain may be a promising approach to characterize individuals who may be vulnerable to developing Alzheimer's disease (AD) prior to significant cognitive decline and irreversible neuronal damage.

30 Jul 2024

Study finds plasma biomarkers can predict dementia risk

A study in JAMA explores the potential of plasma biomarkers for Alzheimer’s disease and cardiometabolic risk factors to predict other types of dementia, highlighting the importance of early diagnosis and combining biomarkers with demographic data for improved accuracy.

30 Jul 2024

Alzheimer's Disease News and Research

Further Reading

Research finds synaptic strength key to maintaining memory in old age

Study uncovers roles of certain brain cells in Alzheimer's plaque formation

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Cambridge experts question efficacy and practicality of new amyloid immunotherapy drugs

Dopamine treatment can reduce Alzheimer's plaques and improve memory

Social factors play crucial role in determining lifespan

Researchers receive $9.5M to study polyphenols' impact on cognitive health

FDA approves AChEI ALPHA-1062 for Alzheimer’s disease treatment

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

New lab technique captures aging effects in Alzheimer's disease development

Fish oil may benefit older adults with genetic Alzheimer's risk

Targeting 14 modifiable risk factors from childhood to old age could prevent or delay dementia

Anticancer drugs show promise in reducing Alzheimer's dementia risk

Exosome-encapsulated fluorescent sensors enable advanced brain imaging in Alzheimer's research

2024 is shaping up to be “the year of iPSCs"

Neurofilament light chain identified as early marker for Parkinson’s and dementia with Lewy Bodies

High-resolution brain maps reveal vascular blueprint for healthy aging

Head-to-head comparison of commercial Alzheimer's blood tests reveals most accurate options

Spatial patterns of cortical microstructural change can be early indicators of Alzheimer's disease risk

Study finds plasma biomarkers can predict dementia risk

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