RNA Sequencing News and Research

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Targeting glutamine metabolism enhances CAR-macrophage cancer therapy

Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function.

20 Apr 2026

Generative AI may help scientists connect the many layers of cancer

A Cell Perspective argues that generative AI models could help tackle cancer’s multiscale, multimodal complexity by complementing the Hallmarks of Cancer framework. It proposes that models capable of complex pattern recognition, multimodal fusion, and contextual reasoning could improve cancer detection, biological discovery, and precision oncology, while still requiring rigorous validation and human oversight.

19 Apr 2026

High-resolution study maps molecular differences across six human cortical regions

A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in gene activity between male and female brains. This may help explain why some psychiatric and neurological disorders appear to affect the biological sexes differently, researchers report.

17 Apr 2026

New lab-grown organoids accurately mimic pediatric brain tumor biology

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

16 Apr 2026

New RNA sequencing method improves rare disease diagnosis

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare diseases.

15 Apr 2026

Brain organoids reveal mutation-specific insights for Rett syndrome

Though many studies approach the developmental disorder Rett syndrome as a single condition arising from general loss of function in the gene MECP2, a new study by neuroscientists in The Picower Institute for Learning and Memory at MIT shows that two different mutations of the gene caused many distinct abnormalities in lab cultures.

15 Apr 2026

SARS-CoV-2 rarely reaches first-trimester placentas but still disrupts early pregnancy immunity

Researchers analyzing 761 first-trimester pregnancies found that SARS-CoV-2 was rarely detected in placental tissues, suggesting in utero transmission early in pregnancy is uncommon. However, maternal infection was linked to immune dysregulation at the maternal-fetal interface, altered trophoblast signaling, and inflammatory changes that could affect placental development.

14 Apr 2026

Pseudogene lncRNAs regulate cancer stem cell behavior and signaling

Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and differentiation.

11 Apr 2026

Study reveals immune aging differs significantly between men and women

Statistics show clear differences in the population's immune system according to sex: men are more susceptible to infections and cancers, while women have stronger immune responses, which translate, for example, into better responses to vaccines.

11 Apr 2026

Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinoma

Gastric-type adenocarcinoma (GAS) is one of the most aggressive non-human papillomavirus (HPV)-associated cervical adenocarcinomas and remains especially difficult to diagnose and treat.

8 Apr 2026

CIPHER-seq technology reveals how immune cells communicate during treatment

A new single-cell technology is giving scientists their clearest view yet of immune cell behavior-capturing not just genetic intent but real-time activity.

8 Apr 2026

Study identifies a common hidden genetic cause of neurodevelopmental disorder in children

Researchers identified biallelic variants in RNU2-2 as the cause of a recessive neurodevelopmental disorder marked by intellectual disability, global developmental delay, and frequent seizures. The study suggests this condition may be the most prevalent known recessive neurodevelopmental disorder currently diagnosable by sequencing, with RNA data pointing to a loss-of-expression mechanism.

2 Apr 2026

Gut microbiome changes improve memory in early cognitive decline

Research shows that modifying the gut microbiome can enhance cognitive performance and mitigate dementia risk, highlighting the gut-brain connection.

1 Apr 2026

How could bisphenol A raise depression risk? Study identifies six key molecular targets

An integrative Translational Psychiatry study linked BPA exposure to major depressive disorder by identifying 571 shared targets and six core genes, with genetic, transcriptomic, docking, and mouse-model data supporting plausible mechanistic pathways. The strongest signals pointed to AKT1, SRC, PLCG2, and JAK3 as potential contributors, while EGFR appeared protective.

31 Mar 2026

Excessive RNA editing enzyme alters brain circuit formation in Down syndrome

A collaborative research study co-led by scientists at the Icahn School of Medicine at Mount Sinai and the Liber Institute for Brain Development has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome.

31 Mar 2026

Uncovering the hidden retinal risks of modern dentistry

Dentists are exposed to intense lighting for long hours, but its long-term impact on eye health is often overlooked. This study evaluates whether chronic exposure to dental lighting, especially blue and white LEDs, can damage the retina and disrupt its normal function. By combining human data with advanced imaging and animal models, the research uncovers hidden occupational risks and highlights the need for safer lighting practices to help protect dentists' vision.

31 Mar 2026

Mount Sinai researchers identify a highly prevalent recessive neurodevelopmental disorder

Researchers at the Icahn School of Medicine at Mount Sinai in New York have identified and described a previously unknown recessive neurodevelopmental disorder (NDD) that appears to be the most prevalent ever discovered.

30 Mar 2026

APOE4 alters brain immunity and cognition differently in females and males

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.

29 Mar 2026

Gut immune responses found to trigger brain inflammation in MS

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS).

27 Mar 2026

Study reveals why haploid fish embryos fail to survive normal development

Naturally occurring haploids are predominantly documented in plants; the first report dates to 1923, when haploid individuals were identified in the Jimson Weed.

26 Mar 2026